Impact of Early Blood Pressure Variability on Stroke Outcomes After Thrombolysis: The SAMURAI rt-PA Registry

Impact of Early Blood Pressure Variability on Stroke Outcomes After Thrombolysis: The SAMURAI rt-PA Registry

The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined as ΔBP (max...

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Veröffentlicht in:Stroke (1970) 2013-03, Vol.44 (3), p.816-818
Hauptverfasser: ENDO, Kaoru, KARIO, Kazuomi, OKUDA, Satoshi, NAMEKAWA, Michito, MIYAGI, Tetsuya, OSAKI, Masato, MINEMATSU, Kazuo, TOYODA, Kazunori, KOGA, Masatoshi, NAKAGAWARA, Jyoji, SHIOKAWA, Yoshiaki, YAMAGAMI, Hiroshi, FURUI, Eisuke, KIMURA, Kazumi, HASEGAWA, Yasuhiro, OKADA, Yasushi
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Intravenous
Aged
Aged, 80 and over
Biological and medical sciences
Blood Pressure - physiology
Cerebral Hemorrhage - epidemiology
Female
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - therapeutic use
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Incidence
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Registries
Stroke - drug therapy
Stroke - physiopathology
Thrombolytic Therapy
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - therapeutic use
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
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Zusammenfassung:The present study determines associations between early blood pressure (BP) variability and stroke outcomes after intravenous thrombolysis. In 527 stroke patients receiving intravenous alteplase (0.6 mg/kg), BP was measured 8 times within the first 25 hours. BP variability was determined as ΔBP (maximum-minimum), standard deviation (SD), coefficient of variation, and successive variation. The systolic BP course was lower among patients with modified Rankin Scale (mRS) 0 to 1 than those without (P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.112.681007