Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus
Objectives While patients with systemic lupus erythematosus (SLE) have poorer health-related quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is...
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| Veröffentlicht in: | Lupus 2013-03, Vol.22 (3), p.254-261 |
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| creator | Mak, A Tang, CS Ho, RC |
| description | Objectives
While patients with systemic lupus erythematosus (SLE) have poorer health-related quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is unclear. We aim to explore potential relationships between lupus-related proinflammatory cytokines, HRQoL and depressive symptoms in patients with SLE.
Methods
Patients with SLE and age-matched healthy subjects were assessed for HRQoL and depressive and anxiety symptoms by the Short Form Health Survey-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) respectively. Using multiplex immunoassay, a panel of serum proinflammatory cytokines including TNFα, interleukin (IL)-1β, IL-6, IL-17, IL-23 and IL-33 were determined and compared between both groups. Independent associations between SF-36, serum proinflammatory cytokine levels and HADS scores were studied by regression models.
Results
In total, 54 patients and 54 healthy controls were studied. Lupus patients had significantly poorer HRQoL (p |
| doi_str_mv | 10.1177/0961203312471872 |
| format | Article |
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While patients with systemic lupus erythematosus (SLE) have poorer health-related quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is unclear. We aim to explore potential relationships between lupus-related proinflammatory cytokines, HRQoL and depressive symptoms in patients with SLE.
Methods
Patients with SLE and age-matched healthy subjects were assessed for HRQoL and depressive and anxiety symptoms by the Short Form Health Survey-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) respectively. Using multiplex immunoassay, a panel of serum proinflammatory cytokines including TNFα, interleukin (IL)-1β, IL-6, IL-17, IL-23 and IL-33 were determined and compared between both groups. Independent associations between SF-36, serum proinflammatory cytokine levels and HADS scores were studied by regression models.
Results
In total, 54 patients and 54 healthy controls were studied. Lupus patients had significantly poorer HRQoL (p < 0.001) and were significantly more depressed (p = 0.006) and anxious (p = 0.022) than their healthy counterparts. Amongst the proinflammatory cytokines studied, serum TNFα was significantly higher in lupus patients (p < 0.001). After multivariate adjustment, higher serum TNFα (β = −0.224, p = 0.047) remained significantly associated with lower SF-36, along with smoking (β = −0.253, p = 0.014) and more severe depressive symptoms (β = −0.433, p = 0.002). In healthy subjects, serum TNFα was associated with depressive symptoms but not with SF-36.
Conclusions
Higher serum TNFα level is independently associated with poorer HRQoL and more severe depressive symptoms in SLE patients. These associations suggest a potential impact of inflammatory response on depressive symptoms and the quality of life in patients with SLE.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203312471872</identifier><identifier>PMID: 23334278</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Anxiety ; Biomarkers - blood ; Chronic illnesses ; Cytokines ; Cytokines - blood ; Depression - etiology ; Disease ; Female ; Health surveys ; Hospitals ; Humans ; Immunoassay ; Lupus ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - diagnosis ; Lupus Erythematosus, Systemic - psychology ; Male ; Medicine ; Mental depression ; Middle Aged ; Quality of Life ; Rheumatology ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF</subject><ispartof>Lupus, 2013-03, Vol.22 (3), p.254-261</ispartof><rights>The Author(s) 2012. Reprints and permissions: sagepub.co.uk/journalsPermissions.nav</rights><rights>SAGE Publications © Mar 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-ed966df8bcbd42aa3e411a6c2acd2c1c12c9f44cf962d3a25a41102bea5d52d63</citedby><cites>FETCH-LOGICAL-c365t-ed966df8bcbd42aa3e411a6c2acd2c1c12c9f44cf962d3a25a41102bea5d52d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203312471872$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203312471872$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23334278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mak, A</creatorcontrib><creatorcontrib>Tang, CS</creatorcontrib><creatorcontrib>Ho, RC</creatorcontrib><title>Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus</title><title>Lupus</title><addtitle>Lupus</addtitle><description>Objectives
While patients with systemic lupus erythematosus (SLE) have poorer health-related quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is unclear. We aim to explore potential relationships between lupus-related proinflammatory cytokines, HRQoL and depressive symptoms in patients with SLE.
Methods
Patients with SLE and age-matched healthy subjects were assessed for HRQoL and depressive and anxiety symptoms by the Short Form Health Survey-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) respectively. Using multiplex immunoassay, a panel of serum proinflammatory cytokines including TNFα, interleukin (IL)-1β, IL-6, IL-17, IL-23 and IL-33 were determined and compared between both groups. Independent associations between SF-36, serum proinflammatory cytokine levels and HADS scores were studied by regression models.
Results
In total, 54 patients and 54 healthy controls were studied. Lupus patients had significantly poorer HRQoL (p < 0.001) and were significantly more depressed (p = 0.006) and anxious (p = 0.022) than their healthy counterparts. Amongst the proinflammatory cytokines studied, serum TNFα was significantly higher in lupus patients (p < 0.001). After multivariate adjustment, higher serum TNFα (β = −0.224, p = 0.047) remained significantly associated with lower SF-36, along with smoking (β = −0.253, p = 0.014) and more severe depressive symptoms (β = −0.433, p = 0.002). In healthy subjects, serum TNFα was associated with depressive symptoms but not with SF-36.
Conclusions
Higher serum TNFα level is independently associated with poorer HRQoL and more severe depressive symptoms in SLE patients. These associations suggest a potential impact of inflammatory response on depressive symptoms and the quality of life in patients with SLE.</description><subject>Adult</subject><subject>Anxiety</subject><subject>Biomarkers - blood</subject><subject>Chronic illnesses</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Depression - etiology</subject><subject>Disease</subject><subject>Female</subject><subject>Health surveys</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Lupus Erythematosus, Systemic - diagnosis</subject><subject>Lupus Erythematosus, Systemic - psychology</subject><subject>Male</subject><subject>Medicine</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Quality of Life</subject><subject>Rheumatology</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAUhS0EotPCnhWyxIZNwK9JMktU8ahUqYu26-iOfUNcJXHqa4Pya_ireDoFoUqsLPt891zrHMbeSPFByqb5KHa1VEJrqUwj20Y9YxtpmqYq7-o52xzk6qCfsFOiOyGElrv6JTtRWmujmnbDfl1jzBNPeQo58hltDOSJ92BTiBWMywC83IEoWA8JHf_p08CXECIfEMY0VBHHB-E-w-jTykPPR98jh9lxh0tEIv8DOa3TksJE3M98geRxTnQ0o5USTt7yMS-ZOMY1DThBCpTpFXvRw0j4-vE8Y7dfPt-cf6sur75enH-6rKyut6lCt6tr17d7u3dGAWg0UkJtFVinrLRS2V1vjO1LME6D2kLRhdojbN1WuVqfsfdH3yWG-4yUusmTxXGEGUOmTpaMWyNUrQr67gl6V7Kby-8eKNMa0zaFEkfqkChF7Lsl-gni2knRHcrrnpZXRt4-Guf9hO7vwJ-2ClAdAYLv-M_W_xn-BqQcpdY</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Mak, A</creator><creator>Tang, CS</creator><creator>Ho, RC</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus</title><author>Mak, A ; Tang, CS ; Ho, RC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-ed966df8bcbd42aa3e411a6c2acd2c1c12c9f44cf962d3a25a41102bea5d52d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Biomarkers - blood</topic><topic>Chronic illnesses</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Depression - etiology</topic><topic>Disease</topic><topic>Female</topic><topic>Health surveys</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - blood</topic><topic>Lupus Erythematosus, Systemic - diagnosis</topic><topic>Lupus Erythematosus, Systemic - psychology</topic><topic>Male</topic><topic>Medicine</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Quality of Life</topic><topic>Rheumatology</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mak, A</creatorcontrib><creatorcontrib>Tang, CS</creatorcontrib><creatorcontrib>Ho, RC</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mak, A</au><au>Tang, CS</au><au>Ho, RC</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2013-03</date><risdate>2013</risdate><volume>22</volume><issue>3</issue><spage>254</spage><epage>261</epage><pages>254-261</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>Objectives
While patients with systemic lupus erythematosus (SLE) have poorer health-related quality of life (HRQoL) and are more depressed than healthy people, the impact of proinflammatory cytokines, particularly tumour necrosis factor-alpha (TNFα), on these unfavourable psychosocial parameters is unclear. We aim to explore potential relationships between lupus-related proinflammatory cytokines, HRQoL and depressive symptoms in patients with SLE.
Methods
Patients with SLE and age-matched healthy subjects were assessed for HRQoL and depressive and anxiety symptoms by the Short Form Health Survey-36 (SF-36) and Hospital Anxiety and Depression Scale (HADS) respectively. Using multiplex immunoassay, a panel of serum proinflammatory cytokines including TNFα, interleukin (IL)-1β, IL-6, IL-17, IL-23 and IL-33 were determined and compared between both groups. Independent associations between SF-36, serum proinflammatory cytokine levels and HADS scores were studied by regression models.
Results
In total, 54 patients and 54 healthy controls were studied. Lupus patients had significantly poorer HRQoL (p < 0.001) and were significantly more depressed (p = 0.006) and anxious (p = 0.022) than their healthy counterparts. Amongst the proinflammatory cytokines studied, serum TNFα was significantly higher in lupus patients (p < 0.001). After multivariate adjustment, higher serum TNFα (β = −0.224, p = 0.047) remained significantly associated with lower SF-36, along with smoking (β = −0.253, p = 0.014) and more severe depressive symptoms (β = −0.433, p = 0.002). In healthy subjects, serum TNFα was associated with depressive symptoms but not with SF-36.
Conclusions
Higher serum TNFα level is independently associated with poorer HRQoL and more severe depressive symptoms in SLE patients. These associations suggest a potential impact of inflammatory response on depressive symptoms and the quality of life in patients with SLE.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>23334278</pmid><doi>10.1177/0961203312471872</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0961-2033 |
| ispartof | Lupus, 2013-03, Vol.22 (3), p.254-261 |
| issn | 0961-2033 1477-0962 |
| language | eng |
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| subjects | Adult Anxiety Biomarkers - blood Chronic illnesses Cytokines Cytokines - blood Depression - etiology Disease Female Health surveys Hospitals Humans Immunoassay Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - psychology Male Medicine Mental depression Middle Aged Quality of Life Rheumatology Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF |
| title | Serum tumour necrosis factor-alpha is associated with poor health-related quality of life and depressive symptoms in patients with systemic lupus erythematosus |
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