Alternative lengthening of telomeres is induced by telomerase inhibitors in Barrett's esophageal cells

A crucial step in the path to the malignant transformation of cells and tumor formation is immortalization, which essentially depends on telomere maintenance. The aim of this study was to investigate the role of telomerase in the progression of Barrett's esophagus. Telomerase activity was measu...

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Veröffentlicht in:	Oncology reports 2013-04, Vol.29 (4), p.1399-1404
Hauptverfasser:	QIN, XIUGUANG, QI, BO, ZHAO, BAOSHENG
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative lengthening of telomeres Apoptosis Apoptosis - drug effects Barrett Esophagus - genetics Barrett Esophagus - pathology Barrett's esophagus Cell cycle Cell division Cell Line, Tumor Cell Proliferation - drug effects Cell Transformation, Neoplastic Chromosomes Deoxyribonucleic acid DNA Enzyme Inhibitors - pharmacology Esophagus Fibroblasts Humans In Situ Hybridization, Fluorescence Plasmids RNA, Small Interfering - genetics Senescence Sister Chromatid Exchange - genetics Studies Telomerase Telomerase - antagonists & inhibitors Telomerase - genetics Telomerase - metabolism telomerase activity telomerase inhibitor Telomere - genetics Telomere Homeostasis - drug effects Telomere Homeostasis - genetics
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