Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?
Aim To evaluate the significance of the cord blood ischemia‐modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia. Methods This prospe...
Gespeichert in:
| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2013-03, Vol.39 (3), p.663-671 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 671 |
|---|---|
| container_issue | 3 |
| container_start_page | 663 |
| container_title | The journal of obstetrics and gynaecology research |
| container_volume | 39 |
| creator | Kumral, Abdullah Okyay, Emre Guclu, Serkan Gencpinar, Pinar Islekel, Gul Huray Oguz, Serife Suna Kant, Melis Demirel, Gamze Duman, Nuray Ozkan, Hasan |
| description | Aim
To evaluate the significance of the cord blood ischemia‐modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia.
Methods
This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. Doppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro/placental ratio (C/P). IMA was measured by means of commercially available ELISA kits and was expressed as picomoles per milliliter.
Results
Ischemia‐modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P |
| doi_str_mv | 10.1111/j.1447-0756.2012.02055.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1312839273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2352491461</sourcerecordid><originalsourceid>FETCH-LOGICAL-i4055-9e8185687ea33c83ec07e257dd0f33dc28ce002610334043cadd442c0dcba7303</originalsourceid><addsrcrecordid>eNpdkc2O0zAUhSMEYn7gFZAlNmwS_JPECRJCqEAZqGYWgJC6sRzbmd6S2MFOZtoX4Xlx2qELvPG1zneuru9JEkRwRuJ5vc1InvMU86LMKCY0wxQXRbZ7lJyfhMexZjlJK8zLs-QihC3GhNekepqcUUZ5VRN8nvxZOK9R0zmnEQS1MT3ItHcaWjAaya6ZerBv0FVAMCIZglMgx6jcw7hBsrHO97JDH9wwdMajFqwGexthi5Trhw7UgR68ubXSKjABSXt4a1Aj3BnkWjQYD1aOsY8Mw2a_A_nuWfKklV0wzx_uy-THp4_fF5_T1c3yavF-lUIeP5zWpiJVUVbcSMZUxYzC3NCCa41bxrSilTIY05JgxnKcMyW1znOqsFaN5Ayzy-TVse_g3e_JhFH0cQum66Q1bgqCMEIrVlPOIvryP3TrJm_jdIKyguY1yUsSqRcP1NT0RovBQy_9XvzbeATeHoF76Mz-pBMs5mTFVswBijlAMScrDsmKnfhys5yr6E-Pfgij2Z380v8SJWe8ED-vl2L9rfi6Wpdrcc3-ArxIp3Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2352491461</pqid></control><display><type>article</type><title>Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Kumral, Abdullah ; Okyay, Emre ; Guclu, Serkan ; Gencpinar, Pinar ; Islekel, Gul Huray ; Oguz, Serife Suna ; Kant, Melis ; Demirel, Gamze ; Duman, Nuray ; Ozkan, Hasan</creator><creatorcontrib>Kumral, Abdullah ; Okyay, Emre ; Guclu, Serkan ; Gencpinar, Pinar ; Islekel, Gul Huray ; Oguz, Serife Suna ; Kant, Melis ; Demirel, Gamze ; Duman, Nuray ; Ozkan, Hasan</creatorcontrib><description>Aim
To evaluate the significance of the cord blood ischemia‐modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia.
Methods
This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. Doppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro/placental ratio (C/P). IMA was measured by means of commercially available ELISA kits and was expressed as picomoles per milliliter.
Results
Ischemia‐modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P < 0.0001). They were higher in newborns with perinatal asphyxia as compared to healthy controls (P = 0.015). The C/P ratio‐pulsatility index (PI) showed a significant difference between normal and complicated pregnancies without perinatal asphyxia (P < 0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio‐PI.
Conclusions
Elevated cord blood IMA levels may be accepted as a useful marker in perinatal asphyxia. Abnormal Doppler examinations are associated with elevated IMA levels in complicated pregnancies.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2012.02055.x</identifier><identifier>PMID: 23278910</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Albumin ; Asphyxia ; Asphyxia Neonatorum - blood ; Asphyxia Neonatorum - diagnostic imaging ; Biomarkers - blood ; Case-Control Studies ; Cord blood ; Doppler imaging ; Female ; Humans ; Infant, Newborn ; Ischemia ; ischemia-modified albumin ; Neonates ; perinatal asphyxia ; Placenta ; Pregnancy ; pregnancy complication ; Pregnancy Complications - blood ; Pregnancy Complications - diagnostic imaging ; prenatal care ; Prospective Studies ; Serum Albumin ; Serum Albumin, Human ; Suffocation ; Ultrasonography, Doppler ; Ultrasonography, Prenatal ; Uterus ; Young Adult</subject><ispartof>The journal of obstetrics and gynaecology research, 2013-03, Vol.39 (3), p.663-671</ispartof><rights>2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology</rights><rights>2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.</rights><rights>Copyright © 2013 Japan Society of Obstetrics and Gynecology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0756.2012.02055.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0756.2012.02055.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23278910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumral, Abdullah</creatorcontrib><creatorcontrib>Okyay, Emre</creatorcontrib><creatorcontrib>Guclu, Serkan</creatorcontrib><creatorcontrib>Gencpinar, Pinar</creatorcontrib><creatorcontrib>Islekel, Gul Huray</creatorcontrib><creatorcontrib>Oguz, Serife Suna</creatorcontrib><creatorcontrib>Kant, Melis</creatorcontrib><creatorcontrib>Demirel, Gamze</creatorcontrib><creatorcontrib>Duman, Nuray</creatorcontrib><creatorcontrib>Ozkan, Hasan</creatorcontrib><title>Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
To evaluate the significance of the cord blood ischemia‐modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia.
Methods
This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. Doppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro/placental ratio (C/P). IMA was measured by means of commercially available ELISA kits and was expressed as picomoles per milliliter.
Results
Ischemia‐modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P < 0.0001). They were higher in newborns with perinatal asphyxia as compared to healthy controls (P = 0.015). The C/P ratio‐pulsatility index (PI) showed a significant difference between normal and complicated pregnancies without perinatal asphyxia (P < 0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio‐PI.
Conclusions
Elevated cord blood IMA levels may be accepted as a useful marker in perinatal asphyxia. Abnormal Doppler examinations are associated with elevated IMA levels in complicated pregnancies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Albumin</subject><subject>Asphyxia</subject><subject>Asphyxia Neonatorum - blood</subject><subject>Asphyxia Neonatorum - diagnostic imaging</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Cord blood</subject><subject>Doppler imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Ischemia</subject><subject>ischemia-modified albumin</subject><subject>Neonates</subject><subject>perinatal asphyxia</subject><subject>Placenta</subject><subject>Pregnancy</subject><subject>pregnancy complication</subject><subject>Pregnancy Complications - blood</subject><subject>Pregnancy Complications - diagnostic imaging</subject><subject>prenatal care</subject><subject>Prospective Studies</subject><subject>Serum Albumin</subject><subject>Serum Albumin, Human</subject><subject>Suffocation</subject><subject>Ultrasonography, Doppler</subject><subject>Ultrasonography, Prenatal</subject><subject>Uterus</subject><subject>Young Adult</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc2O0zAUhSMEYn7gFZAlNmwS_JPECRJCqEAZqGYWgJC6sRzbmd6S2MFOZtoX4Xlx2qELvPG1zneuru9JEkRwRuJ5vc1InvMU86LMKCY0wxQXRbZ7lJyfhMexZjlJK8zLs-QihC3GhNekepqcUUZ5VRN8nvxZOK9R0zmnEQS1MT3ItHcaWjAaya6ZerBv0FVAMCIZglMgx6jcw7hBsrHO97JDH9wwdMajFqwGexthi5Trhw7UgR68ubXSKjABSXt4a1Aj3BnkWjQYD1aOsY8Mw2a_A_nuWfKklV0wzx_uy-THp4_fF5_T1c3yavF-lUIeP5zWpiJVUVbcSMZUxYzC3NCCa41bxrSilTIY05JgxnKcMyW1znOqsFaN5Ayzy-TVse_g3e_JhFH0cQum66Q1bgqCMEIrVlPOIvryP3TrJm_jdIKyguY1yUsSqRcP1NT0RovBQy_9XvzbeATeHoF76Mz-pBMs5mTFVswBijlAMScrDsmKnfhys5yr6E-Pfgij2Z380v8SJWe8ED-vl2L9rfi6Wpdrcc3-ArxIp3Q</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Kumral, Abdullah</creator><creator>Okyay, Emre</creator><creator>Guclu, Serkan</creator><creator>Gencpinar, Pinar</creator><creator>Islekel, Gul Huray</creator><creator>Oguz, Serife Suna</creator><creator>Kant, Melis</creator><creator>Demirel, Gamze</creator><creator>Duman, Nuray</creator><creator>Ozkan, Hasan</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?</title><author>Kumral, Abdullah ; Okyay, Emre ; Guclu, Serkan ; Gencpinar, Pinar ; Islekel, Gul Huray ; Oguz, Serife Suna ; Kant, Melis ; Demirel, Gamze ; Duman, Nuray ; Ozkan, Hasan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i4055-9e8185687ea33c83ec07e257dd0f33dc28ce002610334043cadd442c0dcba7303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Albumin</topic><topic>Asphyxia</topic><topic>Asphyxia Neonatorum - blood</topic><topic>Asphyxia Neonatorum - diagnostic imaging</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Cord blood</topic><topic>Doppler imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Ischemia</topic><topic>ischemia-modified albumin</topic><topic>Neonates</topic><topic>perinatal asphyxia</topic><topic>Placenta</topic><topic>Pregnancy</topic><topic>pregnancy complication</topic><topic>Pregnancy Complications - blood</topic><topic>Pregnancy Complications - diagnostic imaging</topic><topic>prenatal care</topic><topic>Prospective Studies</topic><topic>Serum Albumin</topic><topic>Serum Albumin, Human</topic><topic>Suffocation</topic><topic>Ultrasonography, Doppler</topic><topic>Ultrasonography, Prenatal</topic><topic>Uterus</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumral, Abdullah</creatorcontrib><creatorcontrib>Okyay, Emre</creatorcontrib><creatorcontrib>Guclu, Serkan</creatorcontrib><creatorcontrib>Gencpinar, Pinar</creatorcontrib><creatorcontrib>Islekel, Gul Huray</creatorcontrib><creatorcontrib>Oguz, Serife Suna</creatorcontrib><creatorcontrib>Kant, Melis</creatorcontrib><creatorcontrib>Demirel, Gamze</creatorcontrib><creatorcontrib>Duman, Nuray</creatorcontrib><creatorcontrib>Ozkan, Hasan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumral, Abdullah</au><au>Okyay, Emre</au><au>Guclu, Serkan</au><au>Gencpinar, Pinar</au><au>Islekel, Gul Huray</au><au>Oguz, Serife Suna</au><au>Kant, Melis</au><au>Demirel, Gamze</au><au>Duman, Nuray</au><au>Ozkan, Hasan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia?</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2013-03</date><risdate>2013</risdate><volume>39</volume><issue>3</issue><spage>663</spage><epage>671</epage><pages>663-671</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
To evaluate the significance of the cord blood ischemia‐modified albumin (IMA) level as a diagnostic marker for perinatal asphyxia and to determine the associations of IMA levels with the complexity of pregnancy and abnormal Doppler findings, regardless of perinatal asphyxia.
Methods
This prospective study included 169 newborns, sixteen of whom had perinatal asphyxia and 33 who were from complicated pregnancies. Doppler measurements were obtained from the uterine, umbilical and middle cerebral arteries, and the cerebro/placental ratio (C/P). IMA was measured by means of commercially available ELISA kits and was expressed as picomoles per milliliter.
Results
Ischemia‐modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P < 0.0001). They were higher in newborns with perinatal asphyxia as compared to healthy controls (P = 0.015). The C/P ratio‐pulsatility index (PI) showed a significant difference between normal and complicated pregnancies without perinatal asphyxia (P < 0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio‐PI.
Conclusions
Elevated cord blood IMA levels may be accepted as a useful marker in perinatal asphyxia. Abnormal Doppler examinations are associated with elevated IMA levels in complicated pregnancies.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23278910</pmid><doi>10.1111/j.1447-0756.2012.02055.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1341-8076 |
| ispartof | The journal of obstetrics and gynaecology research, 2013-03, Vol.39 (3), p.663-671 |
| issn | 1341-8076 1447-0756 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1312839273 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adolescent Adult Albumin Asphyxia Asphyxia Neonatorum - blood Asphyxia Neonatorum - diagnostic imaging Biomarkers - blood Case-Control Studies Cord blood Doppler imaging Female Humans Infant, Newborn Ischemia ischemia-modified albumin Neonates perinatal asphyxia Placenta Pregnancy pregnancy complication Pregnancy Complications - blood Pregnancy Complications - diagnostic imaging prenatal care Prospective Studies Serum Albumin Serum Albumin, Human Suffocation Ultrasonography, Doppler Ultrasonography, Prenatal Uterus Young Adult |
| title | Cord blood ischemia-modified albumin: Is it associated with abnormal Doppler findings in complicated pregnancies and predictive of perinatal asphyxia? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T13%3A28%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cord%20blood%20ischemia-modified%20albumin:%20Is%20it%20associated%20with%20abnormal%20Doppler%20findings%20in%20complicated%20pregnancies%20and%20predictive%20of%20perinatal%20asphyxia?&rft.jtitle=The%20journal%20of%20obstetrics%20and%20gynaecology%20research&rft.au=Kumral,%20Abdullah&rft.date=2013-03&rft.volume=39&rft.issue=3&rft.spage=663&rft.epage=671&rft.pages=663-671&rft.issn=1341-8076&rft.eissn=1447-0756&rft_id=info:doi/10.1111/j.1447-0756.2012.02055.x&rft_dat=%3Cproquest_pubme%3E2352491461%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2352491461&rft_id=info:pmid/23278910&rfr_iscdi=true |