Activation of Cannabinoid CB2 Receptor–Mediated AMPK/CREB Pathway Reduces Cerebral Ischemic Injury

The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in ischemic injury. However, the role of CB2Rs in the central nervous system, especially neuronal and glial CB2Rs in the cortex, remains unclear. We, therefore, investigated anti-ischemic mechanisms of cortical CB2R...

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Veröffentlicht in:	The American journal of pathology 2013-03, Vol.182 (3), p.928-939
Hauptverfasser:	Choi, In-Young, Ju, Chung, Anthony Jalin, Angela M.A, Lee, Da In, Prather, Paul L, Kim, Won-Ki
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism Animals Brain Injuries - drug therapy Brain Injuries - enzymology Brain Injuries - pathology Brain Ischemia - drug therapy Brain Ischemia - enzymology Brain Ischemia - pathology Brain-Derived Neurotrophic Factor - metabolism Catalase - metabolism Cell Death - drug effects Cerebral Cortex - pathology Cerebral Infarction - enzymology Cerebral Infarction - pathology Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors Cyclic AMP Response Element-Binding Protein - metabolism Free Radical Scavengers - metabolism Glucose - deficiency Male Membrane Potential, Mitochondrial - drug effects Oxidative Stress - drug effects Oxygen - pharmacology Pathology Phosphorylation - drug effects Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Sesquiterpenes - pharmacology Sesquiterpenes - therapeutic use Signal Transduction - drug effects Superoxide Dismutase - metabolism
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