Histomorphological factors in the risk prediction of lymph node metastasis in papillary thyroid carcinoma
Aims Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micr...
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| Veröffentlicht in: | Histopathology 2013-03, Vol.62 (4), p.578-588 |
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| container_title | Histopathology |
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| creator | Chung, Yun J Lee, Jae S Park, So Y Park, Hyo J Cho, Bo Y Park, Sung J Lee, Sei Y Kang, Kyung-Ho Ryu, Han S |
| description | Aims
Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures.
Methods and results
Tissue specimens from 153 patients with histologically confirmed PTC including 112 cases of papillary thyroid microcarcinoma (PTMC) were enrolled in this study. Three histological characteristics (hobnail features, LOCP and micropapillary structures) and several clinicopathological parameters were evaluated for their value in predicting lymph node metastasis. Hobnail features, LOCP and micropapillary structures were each significantly associated with and found to be independent predictive factors for lymph node metastasis (P |
| doi_str_mv | 10.1111/his.12025 |
| format | Article |
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Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures.
Methods and results
Tissue specimens from 153 patients with histologically confirmed PTC including 112 cases of papillary thyroid microcarcinoma (PTMC) were enrolled in this study. Three histological characteristics (hobnail features, LOCP and micropapillary structures) and several clinicopathological parameters were evaluated for their value in predicting lymph node metastasis. Hobnail features, LOCP and micropapillary structures were each significantly associated with and found to be independent predictive factors for lymph node metastasis (P < 0.05). These three histological characteristics were closely correlated with one another (P < 0.001). Six of the seven possible combinations of these three histological characteristics were independently correlated with lymph node metastasis (P < 0.05). Among these combinations, the coincidence of all three histological parameters represented the strongest independent predictive factor for lymph node metastasis (OR: 3.270, P = 0.006).
Conclusions
Our study demonstrates that hobnail features, LOCP and micropapillary structures, either alone or in combinations, represent strong independent predictive factors for lymph node metastasis in PTC.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.12025</identifier><identifier>PMID: 23379688</identifier><identifier>CODEN: HISTDD</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - metabolism ; Carcinoma - metabolism ; Carcinoma - secondary ; Carcinoma, Papillary ; Cell Adhesion ; Cell Polarity ; Female ; hobnail features ; Humans ; loss of cohesiveness/polarity (LOCP) ; lymph node metastasis ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; micropapillary structures ; Middle Aged ; papillary thyroid carcinoma ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - secondary ; Young Adult</subject><ispartof>Histopathology, 2013-03, Vol.62 (4), p.578-588</ispartof><rights>2013 Blackwell Publishing Ltd</rights><rights>2013 Blackwell Publishing Ltd.</rights><rights>Copyright © 2013 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-1723939749cff2000bcf5c581f0c43a5b8957e1d6d6b5af9add47b77f836a61f3</citedby><cites>FETCH-LOGICAL-c3915-1723939749cff2000bcf5c581f0c43a5b8957e1d6d6b5af9add47b77f836a61f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhis.12025$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhis.12025$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23379688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Yun J</creatorcontrib><creatorcontrib>Lee, Jae S</creatorcontrib><creatorcontrib>Park, So Y</creatorcontrib><creatorcontrib>Park, Hyo J</creatorcontrib><creatorcontrib>Cho, Bo Y</creatorcontrib><creatorcontrib>Park, Sung J</creatorcontrib><creatorcontrib>Lee, Sei Y</creatorcontrib><creatorcontrib>Kang, Kyung-Ho</creatorcontrib><creatorcontrib>Ryu, Han S</creatorcontrib><title>Histomorphological factors in the risk prediction of lymph node metastasis in papillary thyroid carcinoma</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims
Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures.
Methods and results
Tissue specimens from 153 patients with histologically confirmed PTC including 112 cases of papillary thyroid microcarcinoma (PTMC) were enrolled in this study. Three histological characteristics (hobnail features, LOCP and micropapillary structures) and several clinicopathological parameters were evaluated for their value in predicting lymph node metastasis. Hobnail features, LOCP and micropapillary structures were each significantly associated with and found to be independent predictive factors for lymph node metastasis (P < 0.05). These three histological characteristics were closely correlated with one another (P < 0.001). Six of the seven possible combinations of these three histological characteristics were independently correlated with lymph node metastasis (P < 0.05). Among these combinations, the coincidence of all three histological parameters represented the strongest independent predictive factor for lymph node metastasis (OR: 3.270, P = 0.006).
Conclusions
Our study demonstrates that hobnail features, LOCP and micropapillary structures, either alone or in combinations, represent strong independent predictive factors for lymph node metastasis in PTC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - secondary</subject><subject>Carcinoma, Papillary</subject><subject>Cell Adhesion</subject><subject>Cell Polarity</subject><subject>Female</subject><subject>hobnail features</subject><subject>Humans</subject><subject>loss of cohesiveness/polarity (LOCP)</subject><subject>lymph node metastasis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>micropapillary structures</subject><subject>Middle Aged</subject><subject>papillary thyroid carcinoma</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Young Adult</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKBDEQRYMoOj4W_oAE3OiiNY9J0lmqqCOIIr6WIZ1OnGh3p0160Pl7o6MuBIuC2px7qboFwDZGBzjX4dSnA0wQYUtghClnBWFMLoMRokgWCHOxBtZTekYIC0rIKlgjlArJy3IE_MSnIbQh9tPQhCdvdAOdNkOICfoODlMLo08vsI-29mbwoYPBwWbe9lPYhdrC1g465fZffK973zQ6zrNyHoOvodHR-C60ehOsON0ku_U9N8D92endyaS4vD6_ODm6LAyVmBVYECqpFGNpnCMIoco4ZliJHTJjqllVSiYsrnnNK6ad1HU9FpUQrqRcc-zoBthb-PYxvM5sGlTrk7F5q86GWVKYYsI5wQRndPcP-hxmscvbfVJizDkrZab2F5SJIaVoneqjb_ONCiP1mb_K-auv_DO78-04q1pb_5I_gWfgcAG8-cbO_3dSk4vbH8tiociPsu-_Ch1fFBdUMPV4da7Ojm8IZ-xWPdAPdY2e9g</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Chung, Yun J</creator><creator>Lee, Jae S</creator><creator>Park, So Y</creator><creator>Park, Hyo J</creator><creator>Cho, Bo Y</creator><creator>Park, Sung J</creator><creator>Lee, Sei Y</creator><creator>Kang, Kyung-Ho</creator><creator>Ryu, Han S</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Histomorphological factors in the risk prediction of lymph node metastasis in papillary thyroid carcinoma</title><author>Chung, Yun J ; Lee, Jae S ; Park, So Y ; Park, Hyo J ; Cho, Bo Y ; Park, Sung J ; Lee, Sei Y ; Kang, Kyung-Ho ; Ryu, Han S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-1723939749cff2000bcf5c581f0c43a5b8957e1d6d6b5af9add47b77f836a61f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - secondary</topic><topic>Carcinoma, Papillary</topic><topic>Cell Adhesion</topic><topic>Cell Polarity</topic><topic>Female</topic><topic>hobnail features</topic><topic>Humans</topic><topic>loss of cohesiveness/polarity (LOCP)</topic><topic>lymph node metastasis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>micropapillary structures</topic><topic>Middle Aged</topic><topic>papillary thyroid carcinoma</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Yun J</creatorcontrib><creatorcontrib>Lee, Jae S</creatorcontrib><creatorcontrib>Park, So Y</creatorcontrib><creatorcontrib>Park, Hyo J</creatorcontrib><creatorcontrib>Cho, Bo Y</creatorcontrib><creatorcontrib>Park, Sung J</creatorcontrib><creatorcontrib>Lee, Sei Y</creatorcontrib><creatorcontrib>Kang, Kyung-Ho</creatorcontrib><creatorcontrib>Ryu, Han S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Yun J</au><au>Lee, Jae S</au><au>Park, So Y</au><au>Park, Hyo J</au><au>Cho, Bo Y</au><au>Park, Sung J</au><au>Lee, Sei Y</au><au>Kang, Kyung-Ho</au><au>Ryu, Han S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histomorphological factors in the risk prediction of lymph node metastasis in papillary thyroid carcinoma</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2013-03</date><risdate>2013</risdate><volume>62</volume><issue>4</issue><spage>578</spage><epage>588</epage><pages>578-588</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><coden>HISTDD</coden><abstract>Aims
Few clinicopathological parameters have been identified as independent predictive factors for lymph node metastasis. This study evaluated the predictive ability of three histological characteristics of PTC in lymph node metastases: hobnail features, loss of cohesiveness/polarity (LOCP) and micropapillary structures.
Methods and results
Tissue specimens from 153 patients with histologically confirmed PTC including 112 cases of papillary thyroid microcarcinoma (PTMC) were enrolled in this study. Three histological characteristics (hobnail features, LOCP and micropapillary structures) and several clinicopathological parameters were evaluated for their value in predicting lymph node metastasis. Hobnail features, LOCP and micropapillary structures were each significantly associated with and found to be independent predictive factors for lymph node metastasis (P < 0.05). These three histological characteristics were closely correlated with one another (P < 0.001). Six of the seven possible combinations of these three histological characteristics were independently correlated with lymph node metastasis (P < 0.05). Among these combinations, the coincidence of all three histological parameters represented the strongest independent predictive factor for lymph node metastasis (OR: 3.270, P = 0.006).
Conclusions
Our study demonstrates that hobnail features, LOCP and micropapillary structures, either alone or in combinations, represent strong independent predictive factors for lymph node metastasis in PTC.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23379688</pmid><doi>10.1111/his.12025</doi><tpages>11</tpages></addata></record> |
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| ispartof | Histopathology, 2013-03, Vol.62 (4), p.578-588 |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - metabolism Carcinoma - metabolism Carcinoma - secondary Carcinoma, Papillary Cell Adhesion Cell Polarity Female hobnail features Humans loss of cohesiveness/polarity (LOCP) lymph node metastasis Lymph Nodes - pathology Lymphatic Metastasis Male micropapillary structures Middle Aged papillary thyroid carcinoma Predictive Value of Tests Prognosis Risk Assessment Thyroid Cancer, Papillary Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid Neoplasms - secondary Young Adult |
| title | Histomorphological factors in the risk prediction of lymph node metastasis in papillary thyroid carcinoma |
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