Pregnancy-associated miRNA-clusters
Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasm...
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Veröffentlicht in: | Journal of reproductive immunology 2013-03, Vol.97 (1), p.51-61 |
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creator | Morales-Prieto, Diana M Ospina-Prieto, Stephanie Chaiwangyen, Wittaya Schoenleben, Michael Markert, Udo R |
description | Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. This review summarizes current knowledge on the pregnancy-related miRNA clusters – the C19MC, C14MC and miR-371-3 cluster – in regard to pregnancy and also other, mostly pathological circumstances. |
doi_str_mv | 10.1016/j.jri.2012.11.001 |
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An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. This review summarizes current knowledge on the pregnancy-related miRNA clusters – the C19MC, C14MC and miR-371-3 cluster – in regard to pregnancy and also other, mostly pathological circumstances.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/j.jri.2012.11.001</identifier><identifier>PMID: 23432872</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; C14MC ; C19MC ; Chromosomes, Human, Pair 14 - genetics ; Chromosomes, Human, Pair 19 - genetics ; Female ; Humans ; MicroRNA ; MicroRNAs - genetics ; miR-371-3 ; Multigene Family - genetics ; Obstetrics and Gynecology ; Placenta ; Placenta - metabolism ; Pregnancy ; Pregnancy - genetics ; Pregnancy Complications - genetics ; Trophoblast</subject><ispartof>Journal of reproductive immunology, 2013-03, Vol.97 (1), p.51-61</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-7c1b69bb9e7608b653b4fb239d46659effc4014fb23949578787987b015577c33</citedby><cites>FETCH-LOGICAL-c408t-7c1b69bb9e7608b653b4fb239d46659effc4014fb23949578787987b015577c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jri.2012.11.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23432872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morales-Prieto, Diana M</creatorcontrib><creatorcontrib>Ospina-Prieto, Stephanie</creatorcontrib><creatorcontrib>Chaiwangyen, Wittaya</creatorcontrib><creatorcontrib>Schoenleben, Michael</creatorcontrib><creatorcontrib>Markert, Udo R</creatorcontrib><title>Pregnancy-associated miRNA-clusters</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. This review summarizes current knowledge on the pregnancy-related miRNA clusters – the C19MC, C14MC and miR-371-3 cluster – in regard to pregnancy and also other, mostly pathological circumstances.</description><subject>Animals</subject><subject>C14MC</subject><subject>C19MC</subject><subject>Chromosomes, Human, Pair 14 - genetics</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>MicroRNA</subject><subject>MicroRNAs - genetics</subject><subject>miR-371-3</subject><subject>Multigene Family - genetics</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy - genetics</subject><subject>Pregnancy Complications - genetics</subject><subject>Trophoblast</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1LxDAURYMozjj6A9yI4MZNa17SJi2CMAx-waDixzq06aukdtoxaYX596Z0dOFCsgiEc2945xFyDDQECuKiCitrQkaBhQAhpbBDppBIFkhB-S6ZeiYOKJfJhBw4V3lA0hT2yYTxiDMPTsnZk8X3Jmv0Jsica7XJOixOV-b5YR7ouncdWndI9sqsdni0vWfk7eb6dXEXLB9v7xfzZaAjmnSB1JCLNM9T9N8nuYh5HpU542kRCRGnWJaeg_EpSmOZ-JMmMqcQx1JqzmfkfOxd2_azR9eplXEa6zprsO2dAg5MCOASPAojqm3rnMVSra1ZZXajgKrBjaqUd6MGNwpA-dF95mRb3-crLH4TPzI8cDkC6If8MmiV0wYbjYWxqDtVtObf-qs_aV2bxuis_sANuqrtbePtKVCOKapehuUMuwFGqYgZ598E4YZC</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Morales-Prieto, Diana M</creator><creator>Ospina-Prieto, Stephanie</creator><creator>Chaiwangyen, Wittaya</creator><creator>Schoenleben, Michael</creator><creator>Markert, Udo R</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Pregnancy-associated miRNA-clusters</title><author>Morales-Prieto, Diana M ; Ospina-Prieto, Stephanie ; Chaiwangyen, Wittaya ; Schoenleben, Michael ; Markert, Udo R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-7c1b69bb9e7608b653b4fb239d46659effc4014fb23949578787987b015577c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>C14MC</topic><topic>C19MC</topic><topic>Chromosomes, Human, Pair 14 - genetics</topic><topic>Chromosomes, Human, Pair 19 - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>MicroRNA</topic><topic>MicroRNAs - genetics</topic><topic>miR-371-3</topic><topic>Multigene Family - genetics</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy - genetics</topic><topic>Pregnancy Complications - genetics</topic><topic>Trophoblast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morales-Prieto, Diana M</creatorcontrib><creatorcontrib>Ospina-Prieto, Stephanie</creatorcontrib><creatorcontrib>Chaiwangyen, Wittaya</creatorcontrib><creatorcontrib>Schoenleben, Michael</creatorcontrib><creatorcontrib>Markert, Udo R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morales-Prieto, Diana M</au><au>Ospina-Prieto, Stephanie</au><au>Chaiwangyen, Wittaya</au><au>Schoenleben, Michael</au><au>Markert, Udo R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy-associated miRNA-clusters</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>97</volume><issue>1</issue><spage>51</spage><epage>61</epage><pages>51-61</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><abstract>Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. This review summarizes current knowledge on the pregnancy-related miRNA clusters – the C19MC, C14MC and miR-371-3 cluster – in regard to pregnancy and also other, mostly pathological circumstances.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23432872</pmid><doi>10.1016/j.jri.2012.11.001</doi><tpages>11</tpages></addata></record> |
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subjects | Animals C14MC C19MC Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 19 - genetics Female Humans MicroRNA MicroRNAs - genetics miR-371-3 Multigene Family - genetics Obstetrics and Gynecology Placenta Placenta - metabolism Pregnancy Pregnancy - genetics Pregnancy Complications - genetics Trophoblast |
title | Pregnancy-associated miRNA-clusters |
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