Pregnancy-associated miRNA-clusters

Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasm...

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Veröffentlicht in:Journal of reproductive immunology 2013-03, Vol.97 (1), p.51-61
Hauptverfasser: Morales-Prieto, Diana M, Ospina-Prieto, Stephanie, Chaiwangyen, Wittaya, Schoenleben, Michael, Markert, Udo R
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container_end_page 61
container_issue 1
container_start_page 51
container_title Journal of reproductive immunology
container_volume 97
creator Morales-Prieto, Diana M
Ospina-Prieto, Stephanie
Chaiwangyen, Wittaya
Schoenleben, Michael
Markert, Udo R
description Abstract MicroRNAs (miRNAs) are expressed in the placenta and can be detected in maternal plasma. An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. This review summarizes current knowledge on the pregnancy-related miRNA clusters – the C19MC, C14MC and miR-371-3 cluster – in regard to pregnancy and also other, mostly pathological circumstances.
doi_str_mv 10.1016/j.jri.2012.11.001
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An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. 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An increasing number of studies have been published on the cellular origin, distribution and function of miRNAs in pregnancy. Specific miRNA profiles have been described for the placenta, maternal plasma and several pregnancy disorders. It has been observed that numerous miRNAs, which are predominantly or exclusively expressed during pregnancy, are clustered in chromosomal regions, may be controlled by the same promoters, may have similar seed regions and targets, and work synergistically. The three most eminent clusters are the chromosome 19 miRNA cluster (C19MC), C14MC and miR-371-3 cluster, which is also localized on chromosome 19. MiRNA members of these clusters are not only detected in the placenta, but also in other compartments, e.g. in serum where they have the potential to become novel biomarkers of pregnancy disorders. Additionally, some members are also expressed in a variety of tumors. Antagonism of selected miRNAs or their targets may lead to novel strategies for the development of new drug classes in pregnancy disorders or other diseases. 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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Animals
C14MC
C19MC
Chromosomes, Human, Pair 14 - genetics
Chromosomes, Human, Pair 19 - genetics
Female
Humans
MicroRNA
MicroRNAs - genetics
miR-371-3
Multigene Family - genetics
Obstetrics and Gynecology
Placenta
Placenta - metabolism
Pregnancy
Pregnancy - genetics
Pregnancy Complications - genetics
Trophoblast
title Pregnancy-associated miRNA-clusters
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