Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study
Carvedilol and N-acetyl cysteine (NAC) have antioxidant and anti-inflammatory properties. Aim was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF). Patients undergoing cardiac surgery (n = 311) were randomized...
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| Veröffentlicht in: | European heart journal 2013-02, Vol.34 (8), p.597-604 |
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| container_title | European heart journal |
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| creator | Ozaydin, Mehmet Icli, Atilla Yucel, Habil Akcay, Selahaddin Peker, Oktay Erdogan, Dogan Varol, Ercan Dogan, Abdullah Okutan, Huseyin |
| description | Carvedilol and N-acetyl cysteine (NAC) have antioxidant and anti-inflammatory properties. Aim was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF).
Patients undergoing cardiac surgery (n = 311) were randomized to metoprolol, carvedilol, or carvedilol plus NAC. Baseline characteristics were similar. The incidence of POAF was lower in the carvedilol plus NAC group compared with the metoprolol group (P < 0.0001) or the carvedilol group (P = 0.03). There was a borderline significance for lower POAF rates in the carvedilol group compared with the metoprolol group (P = 0.06). Duration of hospitalization was lower in the carvedilol plus NAC group compared to the metoprolol group (P = 0.004). Multivariate independent predictors of POAF included left-atrial diameter, hypertension, bypass duration, pre-randomization and pre-operative heart rates, carvedilol plus NAC group vs. metoprolol group, and carvedilol plus NAC group vs. carvedilol group.
Carvedilol plus NAC decreased POAF incidence and duration of hospitalization compared with metoprolol and decreased POAF incidence compared with carvedilol. |
| doi_str_mv | 10.1093/eurheartj/ehs423 |
| format | Article |
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Patients undergoing cardiac surgery (n = 311) were randomized to metoprolol, carvedilol, or carvedilol plus NAC. Baseline characteristics were similar. The incidence of POAF was lower in the carvedilol plus NAC group compared with the metoprolol group (P < 0.0001) or the carvedilol group (P = 0.03). There was a borderline significance for lower POAF rates in the carvedilol group compared with the metoprolol group (P = 0.06). Duration of hospitalization was lower in the carvedilol plus NAC group compared to the metoprolol group (P = 0.004). Multivariate independent predictors of POAF included left-atrial diameter, hypertension, bypass duration, pre-randomization and pre-operative heart rates, carvedilol plus NAC group vs. metoprolol group, and carvedilol plus NAC group vs. carvedilol group.
Carvedilol plus NAC decreased POAF incidence and duration of hospitalization compared with metoprolol and decreased POAF incidence compared with carvedilol.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehs423</identifier><identifier>PMID: 23232844</identifier><language>eng</language><publisher>England</publisher><subject>Acetylcysteine - therapeutic use ; Adult ; Aged ; Analysis of Variance ; Anti-Arrhythmia Agents - therapeutic use ; Atrial Fibrillation - drug therapy ; Carbazoles - therapeutic use ; Coronary Artery Bypass ; Double-Blind Method ; Drug Therapy, Combination ; Humans ; Length of Stay ; Metoprolol - therapeutic use ; Middle Aged ; Postoperative Complications - drug therapy ; Propanolamines - therapeutic use ; Treatment Outcome ; Young Adult</subject><ispartof>European heart journal, 2013-02, Vol.34 (8), p.597-604</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c341t-a2676855ca5358600cfcf87011a2168f14b3b3b7513409fc926aaa1e2d0721983</citedby><cites>FETCH-LOGICAL-c341t-a2676855ca5358600cfcf87011a2168f14b3b3b7513409fc926aaa1e2d0721983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23232844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozaydin, Mehmet</creatorcontrib><creatorcontrib>Icli, Atilla</creatorcontrib><creatorcontrib>Yucel, Habil</creatorcontrib><creatorcontrib>Akcay, Selahaddin</creatorcontrib><creatorcontrib>Peker, Oktay</creatorcontrib><creatorcontrib>Erdogan, Dogan</creatorcontrib><creatorcontrib>Varol, Ercan</creatorcontrib><creatorcontrib>Dogan, Abdullah</creatorcontrib><creatorcontrib>Okutan, Huseyin</creatorcontrib><title>Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Carvedilol and N-acetyl cysteine (NAC) have antioxidant and anti-inflammatory properties. Aim was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF).
Patients undergoing cardiac surgery (n = 311) were randomized to metoprolol, carvedilol, or carvedilol plus NAC. Baseline characteristics were similar. The incidence of POAF was lower in the carvedilol plus NAC group compared with the metoprolol group (P < 0.0001) or the carvedilol group (P = 0.03). There was a borderline significance for lower POAF rates in the carvedilol group compared with the metoprolol group (P = 0.06). Duration of hospitalization was lower in the carvedilol plus NAC group compared to the metoprolol group (P = 0.004). Multivariate independent predictors of POAF included left-atrial diameter, hypertension, bypass duration, pre-randomization and pre-operative heart rates, carvedilol plus NAC group vs. metoprolol group, and carvedilol plus NAC group vs. carvedilol group.
Carvedilol plus NAC decreased POAF incidence and duration of hospitalization compared with metoprolol and decreased POAF incidence compared with carvedilol.</description><subject>Acetylcysteine - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Atrial Fibrillation - drug therapy</subject><subject>Carbazoles - therapeutic use</subject><subject>Coronary Artery Bypass</subject><subject>Double-Blind Method</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Metoprolol - therapeutic use</subject><subject>Middle Aged</subject><subject>Postoperative Complications - drug therapy</subject><subject>Propanolamines - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUcFq3DAUFKWhu0l77yno2EO00ZNs2e6thLQJbNJLC70ZWX4mClrLkeSFzafka6tlkyXM4TGPecPwhpCvwFfAG3mJc3hAHdLjJT7EQsgPZAmlEKxRRfmRLDk0JVOq_rcgpzE-cs5rBeoTWQiZURfFkrzcYfJT8M47uo0ranTYYm_31If3bHJzpPdMG0w7R80uJrQjUj_SycfE_IRBJ7tFqlOw2tHBdsE6l3d-_E41DXrs_cY-Y39Bez93Dlnn7JjZ5LJp55nxY8pBHPY0prnffSYng3YRv7zOM_L35_Wfqxu2_v3r9urHmhlZQGJaqErVZWl0KctacW4GM9QVB9ACVD1A0cmMqgRZ8GYwjVBaa0DR80pAU8sz8u3gm9_wNGNM7cZGgzn7iH6OLUgQUKmC76X8IDXBxxhwaKdgNzrsWuDtvpH22Eh7aCSfnL-6z90G--PBWwXyPxMNjaQ</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Ozaydin, Mehmet</creator><creator>Icli, Atilla</creator><creator>Yucel, Habil</creator><creator>Akcay, Selahaddin</creator><creator>Peker, Oktay</creator><creator>Erdogan, Dogan</creator><creator>Varol, Ercan</creator><creator>Dogan, Abdullah</creator><creator>Okutan, Huseyin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study</title><author>Ozaydin, Mehmet ; Icli, Atilla ; Yucel, Habil ; Akcay, Selahaddin ; Peker, Oktay ; Erdogan, Dogan ; Varol, Ercan ; Dogan, Abdullah ; Okutan, Huseyin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-a2676855ca5358600cfcf87011a2168f14b3b3b7513409fc926aaa1e2d0721983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcysteine - therapeutic use</topic><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Atrial Fibrillation - drug therapy</topic><topic>Carbazoles - therapeutic use</topic><topic>Coronary Artery Bypass</topic><topic>Double-Blind Method</topic><topic>Drug Therapy, Combination</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>Metoprolol - therapeutic use</topic><topic>Middle Aged</topic><topic>Postoperative Complications - drug therapy</topic><topic>Propanolamines - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozaydin, Mehmet</creatorcontrib><creatorcontrib>Icli, Atilla</creatorcontrib><creatorcontrib>Yucel, Habil</creatorcontrib><creatorcontrib>Akcay, Selahaddin</creatorcontrib><creatorcontrib>Peker, Oktay</creatorcontrib><creatorcontrib>Erdogan, Dogan</creatorcontrib><creatorcontrib>Varol, Ercan</creatorcontrib><creatorcontrib>Dogan, Abdullah</creatorcontrib><creatorcontrib>Okutan, Huseyin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozaydin, Mehmet</au><au>Icli, Atilla</au><au>Yucel, Habil</au><au>Akcay, Selahaddin</au><au>Peker, Oktay</au><au>Erdogan, Dogan</au><au>Varol, Ercan</au><au>Dogan, Abdullah</au><au>Okutan, Huseyin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>34</volume><issue>8</issue><spage>597</spage><epage>604</epage><pages>597-604</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Carvedilol and N-acetyl cysteine (NAC) have antioxidant and anti-inflammatory properties. Aim was to evaluate the efficacy of metoprolol, carvedilol, and carvedilol plus NAC on the prevention of post-operative atrial fibrillation (POAF).
Patients undergoing cardiac surgery (n = 311) were randomized to metoprolol, carvedilol, or carvedilol plus NAC. Baseline characteristics were similar. The incidence of POAF was lower in the carvedilol plus NAC group compared with the metoprolol group (P < 0.0001) or the carvedilol group (P = 0.03). There was a borderline significance for lower POAF rates in the carvedilol group compared with the metoprolol group (P = 0.06). Duration of hospitalization was lower in the carvedilol plus NAC group compared to the metoprolol group (P = 0.004). Multivariate independent predictors of POAF included left-atrial diameter, hypertension, bypass duration, pre-randomization and pre-operative heart rates, carvedilol plus NAC group vs. metoprolol group, and carvedilol plus NAC group vs. carvedilol group.
Carvedilol plus NAC decreased POAF incidence and duration of hospitalization compared with metoprolol and decreased POAF incidence compared with carvedilol.</abstract><cop>England</cop><pmid>23232844</pmid><doi>10.1093/eurheartj/ehs423</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal, 2013-02, Vol.34 (8), p.597-604 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Acetylcysteine - therapeutic use Adult Aged Analysis of Variance Anti-Arrhythmia Agents - therapeutic use Atrial Fibrillation - drug therapy Carbazoles - therapeutic use Coronary Artery Bypass Double-Blind Method Drug Therapy, Combination Humans Length of Stay Metoprolol - therapeutic use Middle Aged Postoperative Complications - drug therapy Propanolamines - therapeutic use Treatment Outcome Young Adult |
| title | Metoprolol vs. carvedilol or carvedilol plus N-acetyl cysteine on post-operative atrial fibrillation: a randomized, double-blind, placebo-controlled study |
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