Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p

ADP ribosylation factors (Arfs) are the central regulators of vesicle trafficking from the Golgi complex. Activated Arfs facilitate vesicle formation through stimulating coat assembly, activating lipid-modifying enzymes and recruiting tethers and other effectors. Lipid translocases (flippases) have...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (8), p.E668-E677
Hauptverfasser:	Tsai, Pei-Chin, Hsu, Jia-Wei, Liu, Ya-Wen, Chen, Kuan-Yu, Lee, Fang-Jen S
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-Ribosylation Factors - metabolism ADP-Ribosylation Factors - physiology Biological Sciences Calcium-Transporting ATPases - metabolism Cell Membrane - metabolism Cellular biology Fluorescent Antibody Technique, Indirect Guanine Nucleotide Exchange Factors - metabolism Humans Membrane Proteins - physiology Membranes Phosphatidylserines - metabolism PNAS Plus Protein Transport RNA-protein interactions Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - metabolism trans-Golgi Network - metabolism Two-Hybrid System Techniques Yeast
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