Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes
Aim: The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the asso...
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| Veröffentlicht in: | Journal of Atherosclerosis and Thrombosis 2013, Vol.20(2), pp.186-194 |
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| creator | Yamazaki, Yuko Emoto, Masanori Morioka, Tomoaki Kawano, Naoya Lee, Eiko Urata, Hiromi Tsuchikura, Shoko Motoyama, Koka Mori, Katsuhito Fukumoto, Shinya Shoji, Tetsuo Nishizawa, Yoshiki Inaba, Masaaki |
| description | Aim: The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin and the soluble leptin receptor (sOb-R) with atherosclerosis in patients with type 2 diabetes. Methods: Three hundred seventeen type 2 diabetic subjects were enrolled in this cross-sectional study. Fasting plasma leptin and sOb-R concentrations were measured by enzyme-linked immunosorbent assays. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Results: The IMT was significantly associated with sOb-R concentrations, age, diabetes duration, serum creatinine (sCre) levels, and systolic blood pressure (SBP), but not with leptin concentrations or the leptin/sOb-R ratio. The concentrations of leptin (r=0.478, p |
| doi_str_mv | 10.5551/jat.14662 |
| format | Article |
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Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin and the soluble leptin receptor (sOb-R) with atherosclerosis in patients with type 2 diabetes. Methods: Three hundred seventeen type 2 diabetic subjects were enrolled in this cross-sectional study. Fasting plasma leptin and sOb-R concentrations were measured by enzyme-linked immunosorbent assays. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Results: The IMT was significantly associated with sOb-R concentrations, age, diabetes duration, serum creatinine (sCre) levels, and systolic blood pressure (SBP), but not with leptin concentrations or the leptin/sOb-R ratio. The concentrations of leptin (r=0.478, p<0.001) and the sOb-R (r= −0.404, p<0.001) and the leptin/sOb-R ratio (r=0.501, p<0.001) were strongly correlated with IMT in subjects treated with insulin for glycemic control, but not in those treated with diet alone or oral hypoglycemic agents. Multiple regression analysis, including age, sex, diabetes duration, body mass index, SBP, HbA1c, triglycerides, LDL-cholesterol, sCre, smoking, and insulin therapy, revealed that plasma leptin and the leptin/sOb-R ratio were independently associated with IMT in subjects treated with insulin. Conclusions: Plasma leptin and the leptin/sOb-R ratio are associated with atherosclerosis in patients with type 2 diabetes on insulin therapy, and these associations were independent of obesity and other cardiovascular risk factors.</description><identifier>ISSN: 1340-3478</identifier><identifier>EISSN: 1880-3873</identifier><identifier>DOI: 10.5551/jat.14662</identifier><identifier>PMID: 23124060</identifier><language>eng</language><publisher>Japan: Japan Atherosclerosis Society</publisher><subject>Adipocytes - cytology ; Adult ; Aged ; Aged, 80 and over ; Atherosclerosis ; Atherosclerosis - blood ; Cardiovascular Diseases - blood ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - blood ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Female ; Humans ; Intima-media thickness ; Leptin - blood ; Male ; Middle Aged ; Obesity - physiopathology ; Plasma leptin ; Receptors, Leptin - blood ; sObR</subject><ispartof>Journal of Atherosclerosis and Thrombosis, 2013, Vol.20(2), pp.186-194</ispartof><rights>2013 Japan Atherosclerosis Society</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-237ce4388d995e9f0e1f9709fe4fe9f49807816a7be1a7fc6f8307ddbb8d40893</citedby><cites>FETCH-LOGICAL-c466t-237ce4388d995e9f0e1f9709fe4fe9f49807816a7be1a7fc6f8307ddbb8d40893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23124060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamazaki, Yuko</creatorcontrib><creatorcontrib>Emoto, Masanori</creatorcontrib><creatorcontrib>Morioka, Tomoaki</creatorcontrib><creatorcontrib>Kawano, Naoya</creatorcontrib><creatorcontrib>Lee, Eiko</creatorcontrib><creatorcontrib>Urata, Hiromi</creatorcontrib><creatorcontrib>Tsuchikura, Shoko</creatorcontrib><creatorcontrib>Motoyama, Koka</creatorcontrib><creatorcontrib>Mori, Katsuhito</creatorcontrib><creatorcontrib>Fukumoto, Shinya</creatorcontrib><creatorcontrib>Shoji, Tetsuo</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><title>Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes</title><title>Journal of Atherosclerosis and Thrombosis</title><addtitle>JAT</addtitle><description>Aim: The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin and the soluble leptin receptor (sOb-R) with atherosclerosis in patients with type 2 diabetes. Methods: Three hundred seventeen type 2 diabetic subjects were enrolled in this cross-sectional study. Fasting plasma leptin and sOb-R concentrations were measured by enzyme-linked immunosorbent assays. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Results: The IMT was significantly associated with sOb-R concentrations, age, diabetes duration, serum creatinine (sCre) levels, and systolic blood pressure (SBP), but not with leptin concentrations or the leptin/sOb-R ratio. The concentrations of leptin (r=0.478, p<0.001) and the sOb-R (r= −0.404, p<0.001) and the leptin/sOb-R ratio (r=0.501, p<0.001) were strongly correlated with IMT in subjects treated with insulin for glycemic control, but not in those treated with diet alone or oral hypoglycemic agents. Multiple regression analysis, including age, sex, diabetes duration, body mass index, SBP, HbA1c, triglycerides, LDL-cholesterol, sCre, smoking, and insulin therapy, revealed that plasma leptin and the leptin/sOb-R ratio were independently associated with IMT in subjects treated with insulin. Conclusions: Plasma leptin and the leptin/sOb-R ratio are associated with atherosclerosis in patients with type 2 diabetes on insulin therapy, and these associations were independent of obesity and other cardiovascular risk factors.</description><subject>Adipocytes - cytology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - blood</subject><subject>Cardiovascular Diseases - blood</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Intima-Media Thickness</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Intima-media thickness</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - physiopathology</subject><subject>Plasma leptin</subject><subject>Receptors, Leptin - blood</subject><subject>sObR</subject><issn>1340-3478</issn><issn>1880-3873</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOAyEUhonReKkufAHDUhdVGGYGZmVMvTVpovGyJgxzsDTTYQQmxhfwuaWtdnM4wHf-5HwInVJyWRQFvVqoeEnzssx20CEVgoyZ4Gw39SxPfc7FAToKYUEIY0WR7aODjNEsJyU5RD-T1nZWqxZPl73SETuD4xzwDPpoOxwdfnXtULfblxfQqXEev6hoHXYdfh1q_R8yUd5F2-CblOFd0O2q2oDT4HPioYsBf9k4x2_fPeAM31pVQ4RwjPaMagOc_J0j9H5_9zZ5HM-eHqaTm9lYp_XiOGNcQ86EaKqqgMoQoKbipDKQm3TNK0G4oKXiNVDFjS6NYIQ3TV2LJieiYiN0vsntvfscIES5tEFD26oO3BAkTWIoT5rKhF5sUJ1WCB6M7L1dKv8tKZEr7TJpl2vtiT37ix3qJTRb8t9zAq43wCJE9QFbQPlok6R1VEZktirryO2PnisvoWO_XhaVbw</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Yamazaki, Yuko</creator><creator>Emoto, Masanori</creator><creator>Morioka, Tomoaki</creator><creator>Kawano, Naoya</creator><creator>Lee, Eiko</creator><creator>Urata, Hiromi</creator><creator>Tsuchikura, Shoko</creator><creator>Motoyama, Koka</creator><creator>Mori, Katsuhito</creator><creator>Fukumoto, Shinya</creator><creator>Shoji, Tetsuo</creator><creator>Nishizawa, Yoshiki</creator><creator>Inaba, Masaaki</creator><general>Japan Atherosclerosis Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes</title><author>Yamazaki, Yuko ; Emoto, Masanori ; Morioka, Tomoaki ; Kawano, Naoya ; Lee, Eiko ; Urata, Hiromi ; Tsuchikura, Shoko ; Motoyama, Koka ; Mori, Katsuhito ; Fukumoto, Shinya ; Shoji, Tetsuo ; Nishizawa, Yoshiki ; Inaba, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-237ce4388d995e9f0e1f9709fe4fe9f49807816a7be1a7fc6f8307ddbb8d40893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipocytes - cytology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - blood</topic><topic>Cardiovascular Diseases - blood</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Intima-Media Thickness</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Intima-media thickness</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - physiopathology</topic><topic>Plasma leptin</topic><topic>Receptors, Leptin - blood</topic><topic>sObR</topic><toplevel>online_resources</toplevel><creatorcontrib>Yamazaki, Yuko</creatorcontrib><creatorcontrib>Emoto, Masanori</creatorcontrib><creatorcontrib>Morioka, Tomoaki</creatorcontrib><creatorcontrib>Kawano, Naoya</creatorcontrib><creatorcontrib>Lee, Eiko</creatorcontrib><creatorcontrib>Urata, Hiromi</creatorcontrib><creatorcontrib>Tsuchikura, Shoko</creatorcontrib><creatorcontrib>Motoyama, Koka</creatorcontrib><creatorcontrib>Mori, Katsuhito</creatorcontrib><creatorcontrib>Fukumoto, Shinya</creatorcontrib><creatorcontrib>Shoji, Tetsuo</creatorcontrib><creatorcontrib>Nishizawa, Yoshiki</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamazaki, Yuko</au><au>Emoto, Masanori</au><au>Morioka, Tomoaki</au><au>Kawano, Naoya</au><au>Lee, Eiko</au><au>Urata, Hiromi</au><au>Tsuchikura, Shoko</au><au>Motoyama, Koka</au><au>Mori, Katsuhito</au><au>Fukumoto, Shinya</au><au>Shoji, Tetsuo</au><au>Nishizawa, Yoshiki</au><au>Inaba, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes</atitle><jtitle>Journal of Atherosclerosis and Thrombosis</jtitle><addtitle>JAT</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>20</volume><issue>2</issue><spage>186</spage><epage>194</epage><pages>186-194</pages><issn>1340-3478</issn><eissn>1880-3873</eissn><abstract>Aim: The adipocyte-derived hormone leptin plays a key role in the regulation of food intake and energy expenditure. Recent studies have suggested that leptin is also involved in the pathogenesis of obesity-associated atherosclerosis and cardiovascular disease. In this study, we investigated the associations of leptin and the soluble leptin receptor (sOb-R) with atherosclerosis in patients with type 2 diabetes. Methods: Three hundred seventeen type 2 diabetic subjects were enrolled in this cross-sectional study. Fasting plasma leptin and sOb-R concentrations were measured by enzyme-linked immunosorbent assays. The intima-media thickness (IMT) of the common carotid artery was measured by ultrasound. Results: The IMT was significantly associated with sOb-R concentrations, age, diabetes duration, serum creatinine (sCre) levels, and systolic blood pressure (SBP), but not with leptin concentrations or the leptin/sOb-R ratio. The concentrations of leptin (r=0.478, p<0.001) and the sOb-R (r= −0.404, p<0.001) and the leptin/sOb-R ratio (r=0.501, p<0.001) were strongly correlated with IMT in subjects treated with insulin for glycemic control, but not in those treated with diet alone or oral hypoglycemic agents. Multiple regression analysis, including age, sex, diabetes duration, body mass index, SBP, HbA1c, triglycerides, LDL-cholesterol, sCre, smoking, and insulin therapy, revealed that plasma leptin and the leptin/sOb-R ratio were independently associated with IMT in subjects treated with insulin. Conclusions: Plasma leptin and the leptin/sOb-R ratio are associated with atherosclerosis in patients with type 2 diabetes on insulin therapy, and these associations were independent of obesity and other cardiovascular risk factors.</abstract><cop>Japan</cop><pub>Japan Atherosclerosis Society</pub><pmid>23124060</pmid><doi>10.5551/jat.14662</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipocytes - cytology Adult Aged Aged, 80 and over Atherosclerosis Atherosclerosis - blood Cardiovascular Diseases - blood Carotid Arteries - diagnostic imaging Carotid Artery Diseases - blood Carotid Intima-Media Thickness Cross-Sectional Studies Diabetes Diabetes Mellitus, Type 2 - blood Female Humans Intima-media thickness Leptin - blood Male Middle Aged Obesity - physiopathology Plasma leptin Receptors, Leptin - blood sObR |
| title | Clinical Impact of the Leptin to Soluble Leptin Receptor Ratio on Subclinical Carotid Atherosclerosis in Patients with Type 2 Diabetes |
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