Effect of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease

To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease. Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatm...

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Veröffentlicht in:Journal of Traditional Chinese Medicine 2012-12, Vol.32 (4), p.529-533
Hauptverfasser: Zhu, Hongjun, Lu, Shu, Su, Wei, Gong, Shaoyu, Zhang, Zhibin, Li, Ping
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container_end_page 533
container_issue 4
container_start_page 529
container_title Journal of Traditional Chinese Medicine
container_volume 32
creator Zhu, Hongjun
Lu, Shu
Su, Wei
Gong, Shaoyu
Zhang, Zhibin
Li, Ping
description To observe the effects of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease. Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatment group (control group, n = 56). A normal group of 16 healthy persons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire (SAQ) was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software. The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation (PL), apngina stability (AS), apngina frequency (AF), treatment satisfaction (TS) and disease perception (DP)] between the two groups before treatment (P > 0.05). But after treatment, the scores of SAQ (PL, AS, AF, TS, DP) and NO level were higher than those in the control group, and ET-1 average level in the treatment group was lower than that in the control group. The negative relations between PL and ET-1 and between AF and ET-1 were found in this study. Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment, thus improving vascular endothelial function and life quality. Life quality is related to vascular endothelial function.
doi_str_mv 10.1016/S0254-6272(13)60065-5
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Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatment group (control group, n = 56). A normal group of 16 healthy persons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire (SAQ) was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software. The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation (PL), apngina stability (AS), apngina frequency (AF), treatment satisfaction (TS) and disease perception (DP)] between the two groups before treatment (P &gt; 0.05). But after treatment, the scores of SAQ (PL, AS, AF, TS, DP) and NO level were higher than those in the control group, and ET-1 average level in the treatment group was lower than that in the control group. The negative relations between PL and ET-1 and between AF and ET-1 were found in this study. Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment, thus improving vascular endothelial function and life quality. 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Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatment group (control group, n = 56). A normal group of 16 healthy persons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire (SAQ) was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software. The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation (PL), apngina stability (AS), apngina frequency (AF), treatment satisfaction (TS) and disease perception (DP)] between the two groups before treatment (P &gt; 0.05). But after treatment, the scores of SAQ (PL, AS, AF, TS, DP) and NO level were higher than those in the control group, and ET-1 average level in the treatment group was lower than that in the control group. The negative relations between PL and ET-1 and between AF and ET-1 were found in this study. Liandouqingmai Recipe can raise scores of SAQ and NO level and decline ET level in patients with coronary heart disease on the basis of convertional standard treatment, thus improving vascular endothelial function and life quality. 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Capitalized 101 patients with coronary heart disease were randomly divided into a treatment group (n = 45) treated with Liandouqingmai Recipe and a standard treatment group (control group, n = 56). A normal group of 16 healthy persons was additionally set up. Changes in ET-1 and NO levels were measured and Seatle Angina Questionnaire (SAQ) was adopted in studying life quality before and after treatment for two weeks. The data were analyzed with SPSS 16.0 statistic software. The average level of ET-1 in the normal group was lower and NO higher than that of patients with coronary heart disease. There was no significant difference in the average level of ET-1 and NO and in the scores of SAQ [physical limitation (PL), apngina stability (AS), apngina frequency (AF), treatment satisfaction (TS) and disease perception (DP)] between the two groups before treatment (P &gt; 0.05). 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subjects Aged
Aged, 80 and over
Coronary Disease - drug therapy
Coronary Disease - metabolism
Drugs, Chinese Herbal - administration & dosage
Endothelin-1 - metabolism
Female
Humans
Male
Middle Aged
Quality of Life
Surveys and Questionnaires
title Effect of Liandouqingmai Recipe on life quality and vascular endothelial injury in patients with coronary heart disease
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