Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention

Several large-scale clinical studies have consistently demonstrated that use of inhibitors of renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers was associated with significant reduction of new-onset diabetes in patients with insulin resistanc...

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Veröffentlicht in:	Journal of investigative medicine 2013-03, Vol.61 (3), p.551-557
1. Verfasser:	Prabhakar, Sharma S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensins - metabolism Animals Diabetes Mellitus - metabolism Diabetes Mellitus - prevention & control Humans Insulin - metabolism Insulin Resistance Renin-Angiotensin System Signal Transduction
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description	Several large-scale clinical studies have consistently demonstrated that use of inhibitors of renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers was associated with significant reduction of new-onset diabetes in patients with insulin resistance such as primary hypertension. Such observations stimulated major investigations into the interaction of angiotensin and insulin signaling systems, which in turn led to the discovery of a cross talk at several steps between the 2 pathways. Evidence from these clinical trials and from the experimental models of insulin resistance including our findings in ZSF rat and other animal models will be discussed in this review.
doi_str_mv	10.2310/JIM.0b013e31828298ce
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Evidence from these clinical trials and from the experimental models of insulin resistance including our findings in ZSF rat and other animal models will be discussed in this review.</description><subject>Angiotensins - metabolism</subject><subject>Animals</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes Mellitus - prevention & control</subject><subject>Humans</subject><subject>Insulin - metabolism</subject><subject>Insulin Resistance</subject><subject>Renin-Angiotensin System</subject><subject>Signal Transduction</subject><issn>1081-5589</issn><issn>1708-8267</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAQhi0EomxvgJCPXAJe4qXcUNmKQCAWiVtkO5NilNjFTpF4e1IVOHDgNHP4_n80H0L7lBwxTsnx9fT2iFhCOXCqmWZj7WANbVFFdKGZVOvDTjQthNDjEdrO-Y0QJsWYbaIR41wSXaot9DINr9763seAY4MfIPhQnIaZjz2E7AN-_Mw9dCd42s1b78wSzLiJCZ95Y6GHjCcx9Cm22IQa3yf4gLCEdtFGY9oMe99zBz1fnD9Nroqbu8vp5PSmcEyWfaEaWzrtpCotCMkYN0xQ0LxmNRPCMFLWSjbSEWuJA6sMrUWtxECQ0ihJ-Q46XPXOU3xfQO6rzmcHbWsCxEWuKKeMKqrHfEDLFepSzDlBU82T70z6rCiplk6rwWn11-kQO_i-sLAd1L-hH4kDQFdANjOo3uIiheHj_0u_ABgzgqs</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Prabhakar, Sharma S.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention</title><author>Prabhakar, Sharma S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c264t-7fb4c8c674be56223a251e83d2d255a204d76f6c0bb0ceb7a1d5d75e8304a7613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Angiotensins - metabolism</topic><topic>Animals</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes Mellitus - prevention & control</topic><topic>Humans</topic><topic>Insulin - metabolism</topic><topic>Insulin Resistance</topic><topic>Renin-Angiotensin System</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prabhakar, Sharma S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prabhakar, Sharma S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention</atitle><jtitle>Journal of investigative medicine</jtitle><addtitle>J Investig Med</addtitle><date>2013-03</date><risdate>2013</risdate><volume>61</volume><issue>3</issue><spage>551</spage><epage>557</epage><pages>551-557</pages><issn>1081-5589</issn><eissn>1708-8267</eissn><abstract>Several large-scale clinical studies have consistently demonstrated that use of inhibitors of renin-angiotensin system such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers was associated with significant reduction of new-onset diabetes in patients with insulin resistance such as primary hypertension. 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subjects	Angiotensins - metabolism Animals Diabetes Mellitus - metabolism Diabetes Mellitus - prevention & control Humans Insulin - metabolism Insulin Resistance Renin-Angiotensin System Signal Transduction
title	Inhibition of Renin-Angiotensin System: Implications for Diabetes Control and Prevention
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