Diffuse large B‐cell lymphoma of the ocular adnexal region: A nation‐based study
. Purpose: To characterize the clinicopathological features of diffuse large B‐cell lymphoma (DLBCL) of the ocular adnexal region. Methods: The present series of orbital and adnexal DLBCLs were found by searching the Danish Registry of Pathology between 1980 and 2009. Histological specimens were r...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2013-03, Vol.91 (2), p.163-169 |
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| creator | Rasmussen, Peter K. Ralfkiaer, Elisabeth Prause, Jan U. Sjö, Lene D. Toft, Peter B. Siersma, Volkert D. Heegaard, Steffen |
| description | .
Purpose: To characterize the clinicopathological features of diffuse large B‐cell lymphoma (DLBCL) of the ocular adnexal region.
Methods: The present series of orbital and adnexal DLBCLs were found by searching the Danish Registry of Pathology between 1980 and 2009. Histological specimens were re‐evaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed DLBCL were collected.
Results: A total of 34 patients with DLBCL of the ocular adnexal region were identified. Eighteen of the patients were men. The patients had a median age of 78 years (range 35–97 years). Ninety‐seven per cent of the patients had unilateral ocular adnexal region involvement, and the orbit (76%) was the most frequently affected site. Nineteen patients (56%) presented with Stage I lymphoma. Of these, 18 were diagnosed with primary lymphoma. Four patients (12%) had Stage II, one patient (3%) had Stage III and ten patients (29%) presented with Stage IV lymphoma. The 5‐year overall survival (OS) rate for the whole study group was 20%. The patients with Stage I lymphoma had a significantly better 5‐year OS rate (28%) than patients in Stage II‐IV (5‐year OS rate, 9%). In Cox regression analysis, concordant bone marrow involvement and the International Prognostic Index (IPI) score were prognostic factors for OS.
Conclusions: Diffuse large B‐cell lymphoma of the ocular adnexal region is mainly prevalent in elderly patients. Most patients had unilateral orbital involvement. The overall prognosis is poor. Concordant bone marrow involvement and the IPI score were independent prognostic factors for mortality. |
| doi_str_mv | 10.1111/j.1755-3768.2011.02337.x |
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Purpose: To characterize the clinicopathological features of diffuse large B‐cell lymphoma (DLBCL) of the ocular adnexal region.
Methods: The present series of orbital and adnexal DLBCLs were found by searching the Danish Registry of Pathology between 1980 and 2009. Histological specimens were re‐evaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed DLBCL were collected.
Results: A total of 34 patients with DLBCL of the ocular adnexal region were identified. Eighteen of the patients were men. The patients had a median age of 78 years (range 35–97 years). Ninety‐seven per cent of the patients had unilateral ocular adnexal region involvement, and the orbit (76%) was the most frequently affected site. Nineteen patients (56%) presented with Stage I lymphoma. Of these, 18 were diagnosed with primary lymphoma. Four patients (12%) had Stage II, one patient (3%) had Stage III and ten patients (29%) presented with Stage IV lymphoma. The 5‐year overall survival (OS) rate for the whole study group was 20%. The patients with Stage I lymphoma had a significantly better 5‐year OS rate (28%) than patients in Stage II‐IV (5‐year OS rate, 9%). In Cox regression analysis, concordant bone marrow involvement and the International Prognostic Index (IPI) score were prognostic factors for OS.
Conclusions: Diffuse large B‐cell lymphoma of the ocular adnexal region is mainly prevalent in elderly patients. Most patients had unilateral orbital involvement. The overall prognosis is poor. Concordant bone marrow involvement and the IPI score were independent prognostic factors for mortality.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/j.1755-3768.2011.02337.x</identifier><identifier>PMID: 22551232</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Bone marrow ; Conjunctival Neoplasms - chemistry ; Conjunctival Neoplasms - pathology ; Conjunctival Neoplasms - therapy ; diffuse large B‐cell lymphoma ; Eye Neoplasms - chemistry ; Eye Neoplasms - pathology ; Eye Neoplasms - therapy ; Eyelid Neoplasms - chemistry ; Eyelid Neoplasms - pathology ; Eyelid Neoplasms - therapy ; Female ; Humans ; Lacrimal Apparatus Diseases - pathology ; Lacrimal Apparatus Diseases - therapy ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - chemistry ; Lymphoma, Large B-Cell, Diffuse - pathology ; Lymphoma, Large B-Cell, Diffuse - therapy ; Male ; Middle Aged ; Mortality ; Neoplasm Staging ; ocular adnexal region ; Ophthalmology ; Orbital Neoplasms - chemistry ; Orbital Neoplasms - pathology ; Orbital Neoplasms - therapy ; prognosis ; Registries ; Survival Rate ; treatment</subject><ispartof>Acta ophthalmologica (Oxford, England), 2013-03, Vol.91 (2), p.163-169</ispartof><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation</rights><rights>2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4477-5a562296cb62fe1ad3c1364015c013b36311a8ba3abb356f4f0100d7716fc06e3</citedby><cites>FETCH-LOGICAL-c4477-5a562296cb62fe1ad3c1364015c013b36311a8ba3abb356f4f0100d7716fc06e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1755-3768.2011.02337.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1755-3768.2011.02337.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22551232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasmussen, Peter K.</creatorcontrib><creatorcontrib>Ralfkiaer, Elisabeth</creatorcontrib><creatorcontrib>Prause, Jan U.</creatorcontrib><creatorcontrib>Sjö, Lene D.</creatorcontrib><creatorcontrib>Toft, Peter B.</creatorcontrib><creatorcontrib>Siersma, Volkert D.</creatorcontrib><creatorcontrib>Heegaard, Steffen</creatorcontrib><title>Diffuse large B‐cell lymphoma of the ocular adnexal region: A nation‐based study</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>.
Purpose: To characterize the clinicopathological features of diffuse large B‐cell lymphoma (DLBCL) of the ocular adnexal region.
Methods: The present series of orbital and adnexal DLBCLs were found by searching the Danish Registry of Pathology between 1980 and 2009. Histological specimens were re‐evaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed DLBCL were collected.
Results: A total of 34 patients with DLBCL of the ocular adnexal region were identified. Eighteen of the patients were men. The patients had a median age of 78 years (range 35–97 years). Ninety‐seven per cent of the patients had unilateral ocular adnexal region involvement, and the orbit (76%) was the most frequently affected site. Nineteen patients (56%) presented with Stage I lymphoma. Of these, 18 were diagnosed with primary lymphoma. Four patients (12%) had Stage II, one patient (3%) had Stage III and ten patients (29%) presented with Stage IV lymphoma. The 5‐year overall survival (OS) rate for the whole study group was 20%. The patients with Stage I lymphoma had a significantly better 5‐year OS rate (28%) than patients in Stage II‐IV (5‐year OS rate, 9%). In Cox regression analysis, concordant bone marrow involvement and the International Prognostic Index (IPI) score were prognostic factors for OS.
Conclusions: Diffuse large B‐cell lymphoma of the ocular adnexal region is mainly prevalent in elderly patients. Most patients had unilateral orbital involvement. The overall prognosis is poor. Concordant bone marrow involvement and the IPI score were independent prognostic factors for mortality.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Bone marrow</subject><subject>Conjunctival Neoplasms - chemistry</subject><subject>Conjunctival Neoplasms - pathology</subject><subject>Conjunctival Neoplasms - therapy</subject><subject>diffuse large B‐cell lymphoma</subject><subject>Eye Neoplasms - chemistry</subject><subject>Eye Neoplasms - pathology</subject><subject>Eye Neoplasms - therapy</subject><subject>Eyelid Neoplasms - chemistry</subject><subject>Eyelid Neoplasms - pathology</subject><subject>Eyelid Neoplasms - therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lacrimal Apparatus Diseases - pathology</subject><subject>Lacrimal Apparatus Diseases - therapy</subject><subject>Lymphoma</subject><subject>Lymphoma, Large B-Cell, Diffuse - chemistry</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Lymphoma, Large B-Cell, Diffuse - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>ocular adnexal region</subject><subject>Ophthalmology</subject><subject>Orbital Neoplasms - chemistry</subject><subject>Orbital Neoplasms - pathology</subject><subject>Orbital Neoplasms - therapy</subject><subject>prognosis</subject><subject>Registries</subject><subject>Survival Rate</subject><subject>treatment</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkLtOwzAUhi0EoqXwCsgSC0uDjx3bLRJDKVepUgeKxGY5id0myqXEiWg3HoFn5ElI2tKBCS_-JX__8dGHEAbiQXOuEg8k530mxcCjBMAjlDHprQ5Qd_9wuM_8rYNOnEsIESCEf4w6lHIOlNEumt3F1tbO4FSXc4Nvvz-_QpOmOF1ny0WRaVxYXC0MLsK6IbCOcrPSKS7NPC7yazzCua6a1NQC7UyEXVVH61N0ZHXqzNnu7qHXh_vZ-Kk_mT4-j0eTfuj7Uva55oLSoQgDQa0BHbEQmPAJ8JAAC5hgAHoQaKaDgHFhfUuAkEhKEDYkwrAeutzOXZbFe21cpbLYtevr3BS1U8CAgiRDIRv04g-aFHWZN9u1lPT5kG6owZYKy8K50li1LONMl2sFRLXmVaJaqaoVrFrzamNerZrq-e6DOshMtC_-qm6Amy3wEadm_e_BajR9aRP7AUv0kZQ</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Rasmussen, Peter K.</creator><creator>Ralfkiaer, Elisabeth</creator><creator>Prause, Jan U.</creator><creator>Sjö, Lene D.</creator><creator>Toft, Peter B.</creator><creator>Siersma, Volkert D.</creator><creator>Heegaard, Steffen</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Diffuse large B‐cell lymphoma of the ocular adnexal region: A nation‐based study</title><author>Rasmussen, Peter K. ; Ralfkiaer, Elisabeth ; Prause, Jan U. ; Sjö, Lene D. ; Toft, Peter B. ; Siersma, Volkert D. ; Heegaard, Steffen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4477-5a562296cb62fe1ad3c1364015c013b36311a8ba3abb356f4f0100d7716fc06e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Bone marrow</topic><topic>Conjunctival Neoplasms - chemistry</topic><topic>Conjunctival Neoplasms - pathology</topic><topic>Conjunctival Neoplasms - therapy</topic><topic>diffuse large B‐cell lymphoma</topic><topic>Eye Neoplasms - chemistry</topic><topic>Eye Neoplasms - pathology</topic><topic>Eye Neoplasms - therapy</topic><topic>Eyelid Neoplasms - chemistry</topic><topic>Eyelid Neoplasms - pathology</topic><topic>Eyelid Neoplasms - therapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lacrimal Apparatus Diseases - pathology</topic><topic>Lacrimal Apparatus Diseases - therapy</topic><topic>Lymphoma</topic><topic>Lymphoma, Large B-Cell, Diffuse - chemistry</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Lymphoma, Large B-Cell, Diffuse - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Staging</topic><topic>ocular adnexal region</topic><topic>Ophthalmology</topic><topic>Orbital Neoplasms - chemistry</topic><topic>Orbital Neoplasms - pathology</topic><topic>Orbital Neoplasms - therapy</topic><topic>prognosis</topic><topic>Registries</topic><topic>Survival Rate</topic><topic>treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rasmussen, Peter K.</creatorcontrib><creatorcontrib>Ralfkiaer, Elisabeth</creatorcontrib><creatorcontrib>Prause, Jan U.</creatorcontrib><creatorcontrib>Sjö, Lene D.</creatorcontrib><creatorcontrib>Toft, Peter B.</creatorcontrib><creatorcontrib>Siersma, Volkert D.</creatorcontrib><creatorcontrib>Heegaard, Steffen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rasmussen, Peter K.</au><au>Ralfkiaer, Elisabeth</au><au>Prause, Jan U.</au><au>Sjö, Lene D.</au><au>Toft, Peter B.</au><au>Siersma, Volkert D.</au><au>Heegaard, Steffen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diffuse large B‐cell lymphoma of the ocular adnexal region: A nation‐based study</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2013-03</date><risdate>2013</risdate><volume>91</volume><issue>2</issue><spage>163</spage><epage>169</epage><pages>163-169</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>.
Purpose: To characterize the clinicopathological features of diffuse large B‐cell lymphoma (DLBCL) of the ocular adnexal region.
Methods: The present series of orbital and adnexal DLBCLs were found by searching the Danish Registry of Pathology between 1980 and 2009. Histological specimens were re‐evaluated using a panel of monoclonal antibodies. Clinical files from all patients with confirmed DLBCL were collected.
Results: A total of 34 patients with DLBCL of the ocular adnexal region were identified. Eighteen of the patients were men. The patients had a median age of 78 years (range 35–97 years). Ninety‐seven per cent of the patients had unilateral ocular adnexal region involvement, and the orbit (76%) was the most frequently affected site. Nineteen patients (56%) presented with Stage I lymphoma. Of these, 18 were diagnosed with primary lymphoma. Four patients (12%) had Stage II, one patient (3%) had Stage III and ten patients (29%) presented with Stage IV lymphoma. The 5‐year overall survival (OS) rate for the whole study group was 20%. The patients with Stage I lymphoma had a significantly better 5‐year OS rate (28%) than patients in Stage II‐IV (5‐year OS rate, 9%). In Cox regression analysis, concordant bone marrow involvement and the International Prognostic Index (IPI) score were prognostic factors for OS.
Conclusions: Diffuse large B‐cell lymphoma of the ocular adnexal region is mainly prevalent in elderly patients. Most patients had unilateral orbital involvement. The overall prognosis is poor. Concordant bone marrow involvement and the IPI score were independent prognostic factors for mortality.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22551232</pmid><doi>10.1111/j.1755-3768.2011.02337.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Bone marrow Conjunctival Neoplasms - chemistry Conjunctival Neoplasms - pathology Conjunctival Neoplasms - therapy diffuse large B‐cell lymphoma Eye Neoplasms - chemistry Eye Neoplasms - pathology Eye Neoplasms - therapy Eyelid Neoplasms - chemistry Eyelid Neoplasms - pathology Eyelid Neoplasms - therapy Female Humans Lacrimal Apparatus Diseases - pathology Lacrimal Apparatus Diseases - therapy Lymphoma Lymphoma, Large B-Cell, Diffuse - chemistry Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - therapy Male Middle Aged Mortality Neoplasm Staging ocular adnexal region Ophthalmology Orbital Neoplasms - chemistry Orbital Neoplasms - pathology Orbital Neoplasms - therapy prognosis Registries Survival Rate treatment |
| title | Diffuse large B‐cell lymphoma of the ocular adnexal region: A nation‐based study |
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