Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults

Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear. Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neur...

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Veröffentlicht in:	Neurology 2012-10, Vol.79 (16), p.1645-1652
Hauptverfasser:	YEN YING LIM, ELLIS, Kathryn A, SZOEKE, Cassandra, VILLEMAGNE, Victor L, MARUFF, Paul, PIETRZAK, Robert H, AMES, David, DARBY, David, HARRINGTON, Karra, MARTINS, Ralph N, MASTERS, Colin L, ROWE, Christopher, SAVAGE, Greg
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloidosis - diagnostic imaging Amyloidosis - genetics Amyloidosis - metabolism Apolipoproteins E - genetics Biological and medical sciences Cognition Disorders - diagnostic imaging Cognition Disorders - genetics Cognition Disorders - psychology Data Interpretation, Statistical Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Genotype Humans Linear Models Male Medical sciences Memory Disorders - genetics Memory Disorders - psychology Neurology Neuropsychological Tests Positron-Emission Tomography Prospective Studies Psychiatric Status Rating Scales
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