Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear. Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neur...
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| Veröffentlicht in: | Neurology 2012-10, Vol.79 (16), p.1645-1652 |
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| creator | YEN YING LIM ELLIS, Kathryn A SZOEKE, Cassandra VILLEMAGNE, Victor L MARUFF, Paul PIETRZAK, Robert H AMES, David DARBY, David HARRINGTON, Karra MARTINS, Ralph N MASTERS, Colin L ROWE, Christopher SAVAGE, Greg |
| description | Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear.
Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.
Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral Aβ, individuals with high cerebral Aβ showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ε4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ε4 and cerebral Aβ load was observed for any measure of cognitive function.
In this prospective study of healthy older adults, high cerebral Aβ load was associated with greater decline in episodic and working memory over 18 months. The APOE ε4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral Aβ load. |
| doi_str_mv | 10.1212/WNL.0b013e31826e9ae6 |
| format | Article |
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Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.
Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral Aβ, individuals with high cerebral Aβ showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ε4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ε4 and cerebral Aβ load was observed for any measure of cognitive function.
In this prospective study of healthy older adults, high cerebral Aβ load was associated with greater decline in episodic and working memory over 18 months. The APOE ε4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral Aβ load.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0b013e31826e9ae6</identifier><identifier>PMID: 23071163</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Aged, 80 and over ; Amyloid beta-Peptides - genetics ; Amyloid beta-Peptides - metabolism ; Amyloidosis - diagnostic imaging ; Amyloidosis - genetics ; Amyloidosis - metabolism ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - genetics ; Cognition Disorders - psychology ; Data Interpretation, Statistical ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Genotype ; Humans ; Linear Models ; Male ; Medical sciences ; Memory Disorders - genetics ; Memory Disorders - psychology ; Neurology ; Neuropsychological Tests ; Positron-Emission Tomography ; Prospective Studies ; Psychiatric Status Rating Scales</subject><ispartof>Neurology, 2012-10, Vol.79 (16), p.1645-1652</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-beccb49db1c7a84a131f8b38a290a6689fa779a6b4b375c6e5a1cdb89889a9f23</citedby><cites>FETCH-LOGICAL-c370t-beccb49db1c7a84a131f8b38a290a6689fa779a6b4b375c6e5a1cdb89889a9f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26821549$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23071163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YEN YING LIM</creatorcontrib><creatorcontrib>ELLIS, Kathryn A</creatorcontrib><creatorcontrib>SZOEKE, Cassandra</creatorcontrib><creatorcontrib>VILLEMAGNE, Victor L</creatorcontrib><creatorcontrib>MARUFF, Paul</creatorcontrib><creatorcontrib>PIETRZAK, Robert H</creatorcontrib><creatorcontrib>AMES, David</creatorcontrib><creatorcontrib>DARBY, David</creatorcontrib><creatorcontrib>HARRINGTON, Karra</creatorcontrib><creatorcontrib>MARTINS, Ralph N</creatorcontrib><creatorcontrib>MASTERS, Colin L</creatorcontrib><creatorcontrib>ROWE, Christopher</creatorcontrib><creatorcontrib>SAVAGE, Greg</creatorcontrib><creatorcontrib>AIBL Research Group</creatorcontrib><creatorcontrib>For the AIBL Research Group</creatorcontrib><title>Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults</title><title>Neurology</title><addtitle>Neurology</addtitle><description>Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear.
Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.
Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral Aβ, individuals with high cerebral Aβ showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ε4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ε4 and cerebral Aβ load was observed for any measure of cognitive function.
In this prospective study of healthy older adults, high cerebral Aβ load was associated with greater decline in episodic and working memory over 18 months. The APOE ε4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral Aβ load.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amyloid beta-Peptides - genetics</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Amyloidosis - diagnostic imaging</subject><subject>Amyloidosis - genetics</subject><subject>Amyloidosis - metabolism</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Cognition Disorders - diagnostic imaging</subject><subject>Cognition Disorders - genetics</subject><subject>Cognition Disorders - psychology</subject><subject>Data Interpretation, Statistical</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - genetics</subject><subject>Memory Disorders - psychology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Positron-Emission Tomography</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1LHEEQxRtJ0NXkPxDpSyCX0f6Y7Y-jiEmEJQoqyW2o7qnendDbvU73Bva_z4ibBDx5qkP93ntUPUJOOTvngouLH98X58wxLlFyIxRaQHVAZnwuVKOk-PmOzBgTppFGmyNyXMovxqaltofkSEimOVdyRrr7Oua0xJFiCOgrzYHCehfz0NOYoad1BYle3t1e0yWmXHcbpDlRn5dpqMNvpD36OCSkQ6IrhFhXO5pjP_lBv421fCDvA8SCH_fzhDx-uX64-tYsbr_eXF0uGi81q41D711re8e9BtMClzwYJw0Iy0ApYwNobUG51kk99wrnwH3vjDXGgg1CnpDPL76bMT9tsdRuPRSPMULCvC0dF3a6l2nD3oBOEUy2_BltX1A_5lJGDN1mHNYw7jrOuucWuqmF7nULk-xsn7B1a-z_if6-fQI-7QEoHmIYIfmh_OeUEXzeWvkHUsmRZQ</recordid><startdate>20121016</startdate><enddate>20121016</enddate><creator>YEN YING LIM</creator><creator>ELLIS, Kathryn A</creator><creator>SZOEKE, Cassandra</creator><creator>VILLEMAGNE, Victor L</creator><creator>MARUFF, Paul</creator><creator>PIETRZAK, Robert H</creator><creator>AMES, David</creator><creator>DARBY, David</creator><creator>HARRINGTON, Karra</creator><creator>MARTINS, Ralph N</creator><creator>MASTERS, Colin L</creator><creator>ROWE, Christopher</creator><creator>SAVAGE, Greg</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20121016</creationdate><title>Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults</title><author>YEN YING LIM ; ELLIS, Kathryn A ; SZOEKE, Cassandra ; VILLEMAGNE, Victor L ; MARUFF, Paul ; PIETRZAK, Robert H ; AMES, David ; DARBY, David ; HARRINGTON, Karra ; MARTINS, Ralph N ; MASTERS, Colin L ; ROWE, Christopher ; SAVAGE, Greg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-beccb49db1c7a84a131f8b38a290a6689fa779a6b4b375c6e5a1cdb89889a9f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amyloid beta-Peptides - genetics</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Amyloidosis - diagnostic imaging</topic><topic>Amyloidosis - genetics</topic><topic>Amyloidosis - metabolism</topic><topic>Apolipoproteins E - genetics</topic><topic>Biological and medical sciences</topic><topic>Cognition Disorders - diagnostic imaging</topic><topic>Cognition Disorders - genetics</topic><topic>Cognition Disorders - psychology</topic><topic>Data Interpretation, Statistical</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - genetics</topic><topic>Memory Disorders - psychology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Positron-Emission Tomography</topic><topic>Prospective Studies</topic><topic>Psychiatric Status Rating Scales</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YEN YING LIM</creatorcontrib><creatorcontrib>ELLIS, Kathryn A</creatorcontrib><creatorcontrib>SZOEKE, Cassandra</creatorcontrib><creatorcontrib>VILLEMAGNE, Victor L</creatorcontrib><creatorcontrib>MARUFF, Paul</creatorcontrib><creatorcontrib>PIETRZAK, Robert H</creatorcontrib><creatorcontrib>AMES, David</creatorcontrib><creatorcontrib>DARBY, David</creatorcontrib><creatorcontrib>HARRINGTON, Karra</creatorcontrib><creatorcontrib>MARTINS, Ralph N</creatorcontrib><creatorcontrib>MASTERS, Colin L</creatorcontrib><creatorcontrib>ROWE, Christopher</creatorcontrib><creatorcontrib>SAVAGE, Greg</creatorcontrib><creatorcontrib>AIBL Research Group</creatorcontrib><creatorcontrib>For the AIBL Research Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YEN YING LIM</au><au>ELLIS, Kathryn A</au><au>SZOEKE, Cassandra</au><au>VILLEMAGNE, Victor L</au><au>MARUFF, Paul</au><au>PIETRZAK, Robert H</au><au>AMES, David</au><au>DARBY, David</au><au>HARRINGTON, Karra</au><au>MARTINS, Ralph N</au><au>MASTERS, Colin L</au><au>ROWE, Christopher</au><au>SAVAGE, Greg</au><aucorp>AIBL Research Group</aucorp><aucorp>For the AIBL Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2012-10-16</date><risdate>2012</risdate><volume>79</volume><issue>16</issue><spage>1645</spage><epage>1652</epage><pages>1645-1652</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>Although the APOE ε4 allele is associated with more rapid decline in memory in healthy older adults, the significance of elevated cerebral β-amyloid (Aβ) load for longitudinal changes in cognition is unclear.
Healthy and cognitively normal older adults (n = 141; mean age 76 years) underwent PET neuroimaging for cerebral Aβ, APOE genotyping, and cognitive assessment as part of their baseline assessment in the Australian Imaging Biomarkers and Lifestyle study. Cognitive function was reassessed 18 months later.
Linear mixed-model analyses adjusted for baseline cognitive function indicated that, relative to individuals with low cerebral Aβ, individuals with high cerebral Aβ showed significantly greater decline in working memory and verbal and visual episodic memory at 18 months. Compared with noncarriers, APOE ε4 carriers showed a greater decline in visual memory at the 18-month assessment. No interaction between APOE ε4 and cerebral Aβ load was observed for any measure of cognitive function.
In this prospective study of healthy older adults, high cerebral Aβ load was associated with greater decline in episodic and working memory over 18 months. The APOE ε4 genotype was also associated with a decline in visual memory, although the effect was less than that observed for cerebral Aβ load.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>23071163</pmid><doi>10.1212/WNL.0b013e31826e9ae6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Neurology, 2012-10, Vol.79 (16), p.1645-1652 |
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| subjects | Aged Aged, 80 and over Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloidosis - diagnostic imaging Amyloidosis - genetics Amyloidosis - metabolism Apolipoproteins E - genetics Biological and medical sciences Cognition Disorders - diagnostic imaging Cognition Disorders - genetics Cognition Disorders - psychology Data Interpretation, Statistical Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Genotype Humans Linear Models Male Medical sciences Memory Disorders - genetics Memory Disorders - psychology Neurology Neuropsychological Tests Positron-Emission Tomography Prospective Studies Psychiatric Status Rating Scales |
| title | Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults |
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