Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats

Nicotine has been reported to exert certain protective effect in the Parkinson’s and Alzheimer’s diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (−)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the v...

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Veröffentlicht in:	Neurochemical research 2013-02, Vol.38 (2), p.364-370
Hauptverfasser:	Chen, Yu, Nie, Huang, Tian, Li, Tong, Li, Yang, Lujia, Lao, Ning, Dong, Hailong, Sang, Hanfei, Xiong, Lize
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Arachidonylglycerol Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - prevention & control Cell Biology Endocannabinoids - agonists Endocannabinoids - biosynthesis Endocannabinoids - metabolism Male Neurochemistry Neurology Neuroprotective Agents - therapeutic use Neurosciences Nicotine - therapeutic use Original Paper Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - biosynthesis Up-Regulation - drug effects Up-Regulation - physiology
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