Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats
Nicotine has been reported to exert certain protective effect in the Parkinson’s and Alzheimer’s diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (−)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the v...
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| Veröffentlicht in: | Neurochemical research 2013-02, Vol.38 (2), p.364-370 |
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| creator | Chen, Yu Nie, Huang Tian, Li Tong, Li Yang, Lujia Lao, Ning Dong, Hailong Sang, Hanfei Xiong, Lize |
| description | Nicotine has been reported to exert certain protective effect in the Parkinson’s and Alzheimer’s diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (−)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before the 120 min middle cerebral artery occlusion. Neurological deficits and histological injury were assessed at 24 h after reperfusion. The content of endocannabinoids and the expression of cannabinoid receptor CB1 in brain tissues were determined at different time points after nicotine administration. Results showed that nicotine administration ameliorated neurological deficits and reduced infarct volume induced by cerebral ischemia in the rats. The neuroprotective effect was partially reversed by CB1 blockage. The content of the endocannabinoids
N
-arachidonylethanolamine and 2-arachidonoylglycerol, as well as the expression of cannabinoid receptor CB1 were up-regulated in brain tissues after nicotine delivery. These results suggest that endogenous cannabinoid system is involved in the nicotine-induced neuroprotection against transient focal cerebral ischemia. |
| doi_str_mv | 10.1007/s11064-012-0927-6 |
| format | Article |
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N
-arachidonylethanolamine and 2-arachidonoylglycerol, as well as the expression of cannabinoid receptor CB1 were up-regulated in brain tissues after nicotine delivery. These results suggest that endogenous cannabinoid system is involved in the nicotine-induced neuroprotection against transient focal cerebral ischemia.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-012-0927-6</identifier><identifier>PMID: 23192660</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>2-Arachidonylglycerol ; Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Brain - drug effects ; Brain - metabolism ; Brain - pathology ; Brain Ischemia - metabolism ; Brain Ischemia - pathology ; Brain Ischemia - prevention & control ; Cell Biology ; Endocannabinoids - agonists ; Endocannabinoids - biosynthesis ; Endocannabinoids - metabolism ; Male ; Neurochemistry ; Neurology ; Neuroprotective Agents - therapeutic use ; Neurosciences ; Nicotine - therapeutic use ; Original Paper ; Rats ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1 - agonists ; Receptor, Cannabinoid, CB1 - biosynthesis ; Up-Regulation - drug effects ; Up-Regulation - physiology</subject><ispartof>Neurochemical research, 2013-02, Vol.38 (2), p.364-370</ispartof><rights>Springer Science+Business Media New York 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-96b82340d7996f080e4d8927e9ed33af85b1e1378c7cf56b682f3ff4521320c43</citedby><cites>FETCH-LOGICAL-c471t-96b82340d7996f080e4d8927e9ed33af85b1e1378c7cf56b682f3ff4521320c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11064-012-0927-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11064-012-0927-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23192660$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Nie, Huang</creatorcontrib><creatorcontrib>Tian, Li</creatorcontrib><creatorcontrib>Tong, Li</creatorcontrib><creatorcontrib>Yang, Lujia</creatorcontrib><creatorcontrib>Lao, Ning</creatorcontrib><creatorcontrib>Dong, Hailong</creatorcontrib><creatorcontrib>Sang, Hanfei</creatorcontrib><creatorcontrib>Xiong, Lize</creatorcontrib><title>Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><addtitle>Neurochem Res</addtitle><description>Nicotine has been reported to exert certain protective effect in the Parkinson’s and Alzheimer’s diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (−)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before the 120 min middle cerebral artery occlusion. Neurological deficits and histological injury were assessed at 24 h after reperfusion. The content of endocannabinoids and the expression of cannabinoid receptor CB1 in brain tissues were determined at different time points after nicotine administration. Results showed that nicotine administration ameliorated neurological deficits and reduced infarct volume induced by cerebral ischemia in the rats. The neuroprotective effect was partially reversed by CB1 blockage. The content of the endocannabinoids
N
-arachidonylethanolamine and 2-arachidonoylglycerol, as well as the expression of cannabinoid receptor CB1 were up-regulated in brain tissues after nicotine delivery. These results suggest that endogenous cannabinoid system is involved in the nicotine-induced neuroprotection against transient focal cerebral ischemia.</description><subject>2-Arachidonylglycerol</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Brain Ischemia - metabolism</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - prevention & control</subject><subject>Cell Biology</subject><subject>Endocannabinoids - agonists</subject><subject>Endocannabinoids - biosynthesis</subject><subject>Endocannabinoids - metabolism</subject><subject>Male</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Neurosciences</subject><subject>Nicotine - therapeutic use</subject><subject>Original Paper</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Cannabinoid, CB1 - agonists</subject><subject>Receptor, Cannabinoid, CB1 - biosynthesis</subject><subject>Up-Regulation - drug effects</subject><subject>Up-Regulation - physiology</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kdFrFDEQxoMo9lr9A3yRgC--rE6S3ST7eJRqD0oLrT6HbHZSc9wmNdk9uP_e1KsiQp8GZn7fN5l8hLxj8IkBqM-FMZBtA4w30HPVyBdkxTolGtmDeElWIOpUsB5OyGkpW4Cq4uw1OeG1yaWEFYnXwaU5RGw2cVwcjvQal5wecprRzSFFur63IZaZbor7gVNwdBO3Sz7Usk-7PRa6rtze_maTpxdxTM7GaIcQUxjp3aHMONEQ6a2dyxvyyttdwbdP9Yx8_3Lx7fyyubr5ujlfXzWuVWxuejloLloYVd9LDxqwHXW9EHschbBedwNDJpR2yvlODlJzL7xvO84EB9eKM_Lx6FsP-blgmc0UisPdzkZMSzGM90xyrjWr6If_0G1acqyvq5QC0bFOq0qxI-VyKiWjNw85TDYfDAPzGIY5hmFqGOYxDCOr5v2T8zJMOP5V_Pn9CvAjUOoo3mP-Z_Wzrr8ASL6UUw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Chen, Yu</creator><creator>Nie, Huang</creator><creator>Tian, Li</creator><creator>Tong, Li</creator><creator>Yang, Lujia</creator><creator>Lao, Ning</creator><creator>Dong, Hailong</creator><creator>Sang, Hanfei</creator><creator>Xiong, Lize</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20130201</creationdate><title>Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats</title><author>Chen, Yu ; Nie, Huang ; Tian, Li ; Tong, Li ; Yang, Lujia ; Lao, Ning ; Dong, Hailong ; Sang, Hanfei ; Xiong, Lize</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-96b82340d7996f080e4d8927e9ed33af85b1e1378c7cf56b682f3ff4521320c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2-Arachidonylglycerol</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Brain Ischemia - metabolism</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - prevention & control</topic><topic>Cell Biology</topic><topic>Endocannabinoids - agonists</topic><topic>Endocannabinoids - biosynthesis</topic><topic>Endocannabinoids - metabolism</topic><topic>Male</topic><topic>Neurochemistry</topic><topic>Neurology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Neurosciences</topic><topic>Nicotine - therapeutic use</topic><topic>Original Paper</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Cannabinoid, CB1 - agonists</topic><topic>Receptor, Cannabinoid, CB1 - biosynthesis</topic><topic>Up-Regulation - drug effects</topic><topic>Up-Regulation - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yu</creatorcontrib><creatorcontrib>Nie, Huang</creatorcontrib><creatorcontrib>Tian, Li</creatorcontrib><creatorcontrib>Tong, Li</creatorcontrib><creatorcontrib>Yang, Lujia</creatorcontrib><creatorcontrib>Lao, Ning</creatorcontrib><creatorcontrib>Dong, Hailong</creatorcontrib><creatorcontrib>Sang, Hanfei</creatorcontrib><creatorcontrib>Xiong, Lize</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yu</au><au>Nie, Huang</au><au>Tian, Li</au><au>Tong, Li</au><au>Yang, Lujia</au><au>Lao, Ning</au><au>Dong, Hailong</au><au>Sang, Hanfei</au><au>Xiong, Lize</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>38</volume><issue>2</issue><spage>364</spage><epage>370</epage><pages>364-370</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Nicotine has been reported to exert certain protective effect in the Parkinson’s and Alzheimer’s diseases. Whether it has a similar action in focal cerebral ischemia was unclear. In the present study, rats received either an injection of (−)-nicotine hydrogen tartrate salt (1.2 mg/kg, i.p.) or the vehicle 2 h before the 120 min middle cerebral artery occlusion. Neurological deficits and histological injury were assessed at 24 h after reperfusion. The content of endocannabinoids and the expression of cannabinoid receptor CB1 in brain tissues were determined at different time points after nicotine administration. Results showed that nicotine administration ameliorated neurological deficits and reduced infarct volume induced by cerebral ischemia in the rats. The neuroprotective effect was partially reversed by CB1 blockage. The content of the endocannabinoids
N
-arachidonylethanolamine and 2-arachidonoylglycerol, as well as the expression of cannabinoid receptor CB1 were up-regulated in brain tissues after nicotine delivery. These results suggest that endogenous cannabinoid system is involved in the nicotine-induced neuroprotection against transient focal cerebral ischemia.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23192660</pmid><doi>10.1007/s11064-012-0927-6</doi><tpages>7</tpages></addata></record> |
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| ispartof | Neurochemical research, 2013-02, Vol.38 (2), p.364-370 |
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| subjects | 2-Arachidonylglycerol Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain - pathology Brain Ischemia - metabolism Brain Ischemia - pathology Brain Ischemia - prevention & control Cell Biology Endocannabinoids - agonists Endocannabinoids - biosynthesis Endocannabinoids - metabolism Male Neurochemistry Neurology Neuroprotective Agents - therapeutic use Neurosciences Nicotine - therapeutic use Original Paper Rats Rats, Sprague-Dawley Receptor, Cannabinoid, CB1 - agonists Receptor, Cannabinoid, CB1 - biosynthesis Up-Regulation - drug effects Up-Regulation - physiology |
| title | Nicotine-Induced Neuroprotection Against Ischemic Injury Involves Activation of Endocannabinoid System in Rats |
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