Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain
DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the neocortical organization in rhesus macaque, with particular focus on the differences in the functional annotation of genes in the primary motor cortex (M1...
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| Veröffentlicht in: | Neurochemical research 2013-01, Vol.38 (1), p.133-140 |
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| container_title | Neurochemical research |
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| creator | Kojima, Toshio Higo, Noriyuki Sato, Akira Oishi, Takao Nishimura, Yukio Yamamoto, Tatsuya Murata, Yumi Yoshino-Saito, Kimika Onoe, Hirotaka Isa, Tadashi |
| description | DNA microarray-based genome-wide transcriptional profiling and gene network analyses were used to characterize the molecular underpinnings of the neocortical organization in rhesus macaque, with particular focus on the differences in the functional annotation of genes in the primary motor cortex (M1) and the prefrontal association cortex (area 46 of Brodmann). Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. The annotation appears to have successfully extracted the characteristics of the molecular structure of M1. |
| doi_str_mv | 10.1007/s11064-012-0900-4 |
| format | Article |
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Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. 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Functional annotation of the differentially expressed genes showed that the list of genes selectively expressed in M1 was enriched with genes involved in oligodendrocyte function, and energy consumption. 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| subjects | Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Cell Biology Energy Metabolism - genetics Gene Expression Regulation - physiology Gene Regulatory Networks - genetics Genome-Wide Association Study Macaca mulatta Microarray Analysis Motor Cortex - metabolism Neurochemistry Neurology Neurosciences Oligodendroglia - physiology Original Paper Prefrontal Cortex - metabolism RNA - biosynthesis RNA - isolation & purification |
| title | Functional Annotation of Genes Differentially Expressed Between Primary Motor and Prefrontal Association Cortices of Macaque Brain |
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