The 10 warning signs: a time for a change?

PURPOSE OF REVIEWIt is 20 years since the 10 Warning Signs of primary immunodeficiency (PID) were first published and with over 180 PIDs now identified it is timely to evaluate their effectiveness, given the broadening clinical spectrum of PID. RECENT FINDINGSTwo recent studies have sought to define...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current opinion in allergy and clinical immunology 2012-12, Vol.12 (6), p.588-594
Hauptverfasser: OʼSullivan, Michael D, Cant, Andrew J
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 594
container_issue 6
container_start_page 588
container_title Current opinion in allergy and clinical immunology
container_volume 12
creator OʼSullivan, Michael D
Cant, Andrew J
description PURPOSE OF REVIEWIt is 20 years since the 10 Warning Signs of primary immunodeficiency (PID) were first published and with over 180 PIDs now identified it is timely to evaluate their effectiveness, given the broadening clinical spectrum of PID. RECENT FINDINGSTwo recent studies have sought to define the features that best identify patients with PID and compare these with the 10 Warning Signs. They suggest the 10 Warning Signs discriminate poorly between those with and without PID, and that other features identify about one-third of patients with PID in whom none of the 10 Warning Signs was present. Recent literature describes the diverse presenting features that may assist in more accurately identifying those with PID. SUMMARYFurther development and refinement of early warning signs in light of the growing knowledge of how PIDs manifest clinically may allow relatively simple yet effective guidelines targeted at different groups to better detect PID.
doi_str_mv 10.1097/ACI.0b013e3283591534
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1291621641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1115527011</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3384-ba75395bd15af5b2e8fe1078e7ee50f6c452f244ed774448b288a7d32e7ba53a3</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRbK3-A5EcRUjd2Y_sxouU4keh4KWel00yaaL5qLsJxX9vSqsHD3qaOTzvO8xDyCXQKdBY3c7miylNKHDkTHMZg-TiiIxBKB5GnLHjYZdMh4JKOiJn3r9RCiym7JSMGKcsUgrG5GZVYAA02FrXlM068OW68XeBDbqyxiBv3bCmhW3WeH9OTnJbebw4zAl5fXxYzZ_D5cvTYj5bhinnWoSJVZLHMslA2lwmDHWOQJVGhShpHqVCspwJgZlSQgidMK2tyjhDlVjJLZ-Q633vxrUfPfrO1KVPsapsg23vzfAERAwiAf-jAFIyRWGHij2autZ7h7nZuLK27tMANTuhZhBqfgsdYleHC31SY_YT-jY4AHoPbNuqQ-ffq36LzhRoq674u_sLmvZ_Dw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1115527011</pqid></control><display><type>article</type><title>The 10 warning signs: a time for a change?</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>OʼSullivan, Michael D ; Cant, Andrew J</creator><contributor>Etzioni, A ; Fuleihan, RL</contributor><creatorcontrib>OʼSullivan, Michael D ; Cant, Andrew J ; Etzioni, A ; Fuleihan, RL</creatorcontrib><description>PURPOSE OF REVIEWIt is 20 years since the 10 Warning Signs of primary immunodeficiency (PID) were first published and with over 180 PIDs now identified it is timely to evaluate their effectiveness, given the broadening clinical spectrum of PID. RECENT FINDINGSTwo recent studies have sought to define the features that best identify patients with PID and compare these with the 10 Warning Signs. They suggest the 10 Warning Signs discriminate poorly between those with and without PID, and that other features identify about one-third of patients with PID in whom none of the 10 Warning Signs was present. Recent literature describes the diverse presenting features that may assist in more accurately identifying those with PID. SUMMARYFurther development and refinement of early warning signs in light of the growing knowledge of how PIDs manifest clinically may allow relatively simple yet effective guidelines targeted at different groups to better detect PID.</description><identifier>ISSN: 1528-4050</identifier><identifier>EISSN: 1473-6322</identifier><identifier>DOI: 10.1097/ACI.0b013e3283591534</identifier><identifier>PMID: 23026771</identifier><language>eng</language><publisher>United States: Lippincott Williams &amp; Wilkins, Inc</publisher><subject>Humans ; Immunodeficiency ; Immunologic Deficiency Syndromes - diagnosis ; Immunologic Deficiency Syndromes - immunology ; Reviews</subject><ispartof>Current opinion in allergy and clinical immunology, 2012-12, Vol.12 (6), p.588-594</ispartof><rights>2012 Lippincott Williams &amp; Wilkins, Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3384-ba75395bd15af5b2e8fe1078e7ee50f6c452f244ed774448b288a7d32e7ba53a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23026771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Etzioni, A</contributor><contributor>Fuleihan, RL</contributor><creatorcontrib>OʼSullivan, Michael D</creatorcontrib><creatorcontrib>Cant, Andrew J</creatorcontrib><title>The 10 warning signs: a time for a change?</title><title>Current opinion in allergy and clinical immunology</title><addtitle>Curr Opin Allergy Clin Immunol</addtitle><description>PURPOSE OF REVIEWIt is 20 years since the 10 Warning Signs of primary immunodeficiency (PID) were first published and with over 180 PIDs now identified it is timely to evaluate their effectiveness, given the broadening clinical spectrum of PID. RECENT FINDINGSTwo recent studies have sought to define the features that best identify patients with PID and compare these with the 10 Warning Signs. They suggest the 10 Warning Signs discriminate poorly between those with and without PID, and that other features identify about one-third of patients with PID in whom none of the 10 Warning Signs was present. Recent literature describes the diverse presenting features that may assist in more accurately identifying those with PID. SUMMARYFurther development and refinement of early warning signs in light of the growing knowledge of how PIDs manifest clinically may allow relatively simple yet effective guidelines targeted at different groups to better detect PID.</description><subject>Humans</subject><subject>Immunodeficiency</subject><subject>Immunologic Deficiency Syndromes - diagnosis</subject><subject>Immunologic Deficiency Syndromes - immunology</subject><subject>Reviews</subject><issn>1528-4050</issn><issn>1473-6322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AQhhdRbK3-A5EcRUjd2Y_sxouU4keh4KWel00yaaL5qLsJxX9vSqsHD3qaOTzvO8xDyCXQKdBY3c7miylNKHDkTHMZg-TiiIxBKB5GnLHjYZdMh4JKOiJn3r9RCiym7JSMGKcsUgrG5GZVYAA02FrXlM068OW68XeBDbqyxiBv3bCmhW3WeH9OTnJbebw4zAl5fXxYzZ_D5cvTYj5bhinnWoSJVZLHMslA2lwmDHWOQJVGhShpHqVCspwJgZlSQgidMK2tyjhDlVjJLZ-Q633vxrUfPfrO1KVPsapsg23vzfAERAwiAf-jAFIyRWGHij2autZ7h7nZuLK27tMANTuhZhBqfgsdYleHC31SY_YT-jY4AHoPbNuqQ-ffq36LzhRoq674u_sLmvZ_Dw</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>OʼSullivan, Michael D</creator><creator>Cant, Andrew J</creator><general>Lippincott Williams &amp; Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>201212</creationdate><title>The 10 warning signs: a time for a change?</title><author>OʼSullivan, Michael D ; Cant, Andrew J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3384-ba75395bd15af5b2e8fe1078e7ee50f6c452f244ed774448b288a7d32e7ba53a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Humans</topic><topic>Immunodeficiency</topic><topic>Immunologic Deficiency Syndromes - diagnosis</topic><topic>Immunologic Deficiency Syndromes - immunology</topic><topic>Reviews</topic><toplevel>online_resources</toplevel><creatorcontrib>OʼSullivan, Michael D</creatorcontrib><creatorcontrib>Cant, Andrew J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Current opinion in allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OʼSullivan, Michael D</au><au>Cant, Andrew J</au><au>Etzioni, A</au><au>Fuleihan, RL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 10 warning signs: a time for a change?</atitle><jtitle>Current opinion in allergy and clinical immunology</jtitle><addtitle>Curr Opin Allergy Clin Immunol</addtitle><date>2012-12</date><risdate>2012</risdate><volume>12</volume><issue>6</issue><spage>588</spage><epage>594</epage><pages>588-594</pages><issn>1528-4050</issn><eissn>1473-6322</eissn><abstract>PURPOSE OF REVIEWIt is 20 years since the 10 Warning Signs of primary immunodeficiency (PID) were first published and with over 180 PIDs now identified it is timely to evaluate their effectiveness, given the broadening clinical spectrum of PID. RECENT FINDINGSTwo recent studies have sought to define the features that best identify patients with PID and compare these with the 10 Warning Signs. They suggest the 10 Warning Signs discriminate poorly between those with and without PID, and that other features identify about one-third of patients with PID in whom none of the 10 Warning Signs was present. Recent literature describes the diverse presenting features that may assist in more accurately identifying those with PID. SUMMARYFurther development and refinement of early warning signs in light of the growing knowledge of how PIDs manifest clinically may allow relatively simple yet effective guidelines targeted at different groups to better detect PID.</abstract><cop>United States</cop><pub>Lippincott Williams &amp; Wilkins, Inc</pub><pmid>23026771</pmid><doi>10.1097/ACI.0b013e3283591534</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1528-4050
ispartof Current opinion in allergy and clinical immunology, 2012-12, Vol.12 (6), p.588-594
issn 1528-4050
1473-6322
language eng
recordid cdi_proquest_miscellaneous_1291621641
source MEDLINE; Journals@Ovid Complete
subjects Humans
Immunodeficiency
Immunologic Deficiency Syndromes - diagnosis
Immunologic Deficiency Syndromes - immunology
Reviews
title The 10 warning signs: a time for a change?
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T04%3A26%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%2010%20warning%20signs:%20a%20time%20for%20a%20change?&rft.jtitle=Current%20opinion%20in%20allergy%20and%20clinical%20immunology&rft.au=O%CA%BCSullivan,%20Michael%20D&rft.date=2012-12&rft.volume=12&rft.issue=6&rft.spage=588&rft.epage=594&rft.pages=588-594&rft.issn=1528-4050&rft.eissn=1473-6322&rft_id=info:doi/10.1097/ACI.0b013e3283591534&rft_dat=%3Cproquest_cross%3E1115527011%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1115527011&rft_id=info:pmid/23026771&rfr_iscdi=true