Cerebellar Vermis Size and Cognitive Ability in Community-Dwelling Elderly Men
The cerebellum participates in multiple cognitive functions, including those that are sensitive to decline with aging, and is also vulnerable to atrophy with aging. However, few studies have examined structure–function relationships in older adults. We measured the cross-sectional area of four areas...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2013-02, Vol.12 (1), p.68-73 |
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| container_title | Cerebellum (London, England) |
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| creator | Miller, Thomas D. Ferguson, Karen J. Reid, Louise M. Wardlaw, Joanna M. Starr, John M. Seckl, Jonathan R. Deary, Ian J. MacLullich, Alasdair M. J. |
| description | The cerebellum participates in multiple cognitive functions, including those that are sensitive to decline with aging, and is also vulnerable to atrophy with aging. However, few studies have examined structure–function relationships in older adults. We measured the cross-sectional area of four areas of the cerebellar vermis in 45 community-dwelling men aged 71–76, and correlated this with individual cognitive test scores and two cognitive factors derived from principal components analysis. Two out of the four areas showed positive correlations; vermis area 4 (lobules VIII–X) correlated at
r
= 0.47 (
p
= 0.001) with a general cognitive factor accounting for almost half of the cognitive test variance. These findings support the hypothesis that variations in cerebellar structure are associated with cognitive ability in older adults. |
| doi_str_mv | 10.1007/s12311-012-0397-z |
| format | Article |
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r
= 0.47 (
p
= 0.001) with a general cognitive factor accounting for almost half of the cognitive test variance. These findings support the hypothesis that variations in cerebellar structure are associated with cognitive ability in older adults.</description><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-012-0397-z</identifier><identifier>PMID: 22699965</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Aging ; Aging - pathology ; Aging - physiology ; Atrophy ; Atrophy - pathology ; Atrophy - physiopathology ; Biomedical and Life Sciences ; Biomedicine ; Cerebellum ; Cerebellum - pathology ; Cerebellum - physiology ; Cognition - physiology ; Cognitive ability ; Geriatrics ; Humans ; Male ; Memory - physiology ; Neurobiology ; Neurology ; Neurosciences ; Original Paper ; Principal components analysis ; Residence Characteristics ; Structure-function relationships ; Verbal Behavior - physiology</subject><ispartof>Cerebellum (London, England), 2013-02, Vol.12 (1), p.68-73</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-a448957811612b20a6bb5119dbc4729c4af4223b22d9aa83deed7ce2a1fc39713</citedby><cites>FETCH-LOGICAL-c405t-a448957811612b20a6bb5119dbc4729c4af4223b22d9aa83deed7ce2a1fc39713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-012-0397-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-012-0397-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22699965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Thomas D.</creatorcontrib><creatorcontrib>Ferguson, Karen J.</creatorcontrib><creatorcontrib>Reid, Louise M.</creatorcontrib><creatorcontrib>Wardlaw, Joanna M.</creatorcontrib><creatorcontrib>Starr, John M.</creatorcontrib><creatorcontrib>Seckl, Jonathan R.</creatorcontrib><creatorcontrib>Deary, Ian J.</creatorcontrib><creatorcontrib>MacLullich, Alasdair M. J.</creatorcontrib><title>Cerebellar Vermis Size and Cognitive Ability in Community-Dwelling Elderly Men</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>The cerebellum participates in multiple cognitive functions, including those that are sensitive to decline with aging, and is also vulnerable to atrophy with aging. However, few studies have examined structure–function relationships in older adults. We measured the cross-sectional area of four areas of the cerebellar vermis in 45 community-dwelling men aged 71–76, and correlated this with individual cognitive test scores and two cognitive factors derived from principal components analysis. Two out of the four areas showed positive correlations; vermis area 4 (lobules VIII–X) correlated at
r
= 0.47 (
p
= 0.001) with a general cognitive factor accounting for almost half of the cognitive test variance. These findings support the hypothesis that variations in cerebellar structure are associated with cognitive ability in older adults.</description><subject>Aged</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Atrophy</subject><subject>Atrophy - pathology</subject><subject>Atrophy - physiopathology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cerebellum</subject><subject>Cerebellum - pathology</subject><subject>Cerebellum - physiology</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Principal components analysis</subject><subject>Residence Characteristics</subject><subject>Structure-function relationships</subject><subject>Verbal Behavior - physiology</subject><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkUlPwzAQhS0EomX5AVxQJC5cAp5xmtTHqqwSy4HlajnJtDLKUuwG1P56pioghITEydb4m-d584Q4AHkCUmanAVABxBIwlkpn8XJD9CHJVJygkpvfd8Se2AnhRUpEmWTbooeYaq3TQV_cjclTTlVlffRMvnYhenBLimxTRuN22ri5e6NolLvKzReRa7hY1x2XF_HZO7e5ZhqdVyX5ahHdUrMntia2CrT_ee6Kp4vzx_FVfHN_eT0e3cRFIgfz2CbJUA-yIUAKmKO0aZ4PAHSZF0mGukjshMdWOWKprR2qkqjMCkILk4KNgtoVx2vdmW9fOwpzw5MXKxsNtV0wgJqlNW_nH2imlESph4we_UJf2s43bISplFemWJIpWFOFb0PwNDEz72rrFwakWeVi1rkYzsWscjFL7jn8VO7ymsrvjq8gGMA1EPipmZL_8fWfqh-Ww5au</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Miller, Thomas D.</creator><creator>Ferguson, Karen J.</creator><creator>Reid, Louise M.</creator><creator>Wardlaw, Joanna M.</creator><creator>Starr, John M.</creator><creator>Seckl, Jonathan R.</creator><creator>Deary, Ian J.</creator><creator>MacLullich, Alasdair M. 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r
= 0.47 (
p
= 0.001) with a general cognitive factor accounting for almost half of the cognitive test variance. These findings support the hypothesis that variations in cerebellar structure are associated with cognitive ability in older adults.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22699965</pmid><doi>10.1007/s12311-012-0397-z</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Aging Aging - pathology Aging - physiology Atrophy Atrophy - pathology Atrophy - physiopathology Biomedical and Life Sciences Biomedicine Cerebellum Cerebellum - pathology Cerebellum - physiology Cognition - physiology Cognitive ability Geriatrics Humans Male Memory - physiology Neurobiology Neurology Neurosciences Original Paper Principal components analysis Residence Characteristics Structure-function relationships Verbal Behavior - physiology |
| title | Cerebellar Vermis Size and Cognitive Ability in Community-Dwelling Elderly Men |
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