Common variants in the HLA-DRB1–HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis

Jenefer Blackwell, Peter Donnelly and colleagues report a genome-wide association study for visceral leishmaniasis using studies from India and Brazil, with replication in an additional Indian study. They identify common variants at the HLA-DRB1 – HLA-DQA1 HLA class II region associated with suscept...

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Veröffentlicht in:	Nature genetics 2013-02, Vol.45 (2), p.208-213
Hauptverfasser:	Fakiola, Michaela, Strange, Amy, Cordell, Heather J, Miller, E Nancy, Pirinen, Matti, Su, Zhan, Mishra, Anshuman, Mehrotra, Sanjana, Monteiro, Gloria R, Band, Gavin, Bellenguez, Céline, Dronov, Serge, Edkins, Sarah, Freeman, Colin, Giannoulatou, Eleni, Gray, Emma, Hunt, Sarah E, Lacerda, Henio G, Langford, Cordelia, Pearson, Richard, Pontes, Núbia N, Rai, Madhukar, Singh, Shri P, Smith, Linda, Sousa, Olivia, Vukcevic, Damjan, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin N A, Plomin, Robert, Rautanen, Anna, Sawcer, Stephen J, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas W, Wilson, Mary E, Deloukas, Panos, Peltonen, Leena, Christiansen, Frank, Witt, Campbell, Jeronimo, Selma M B, Sundar, Shyam, Spencer, Chris C A, Blackwell, Jenefer M, Donnelly, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/208/457/649 631/208/727/2000 692/699/255/1715 Agriculture Animal Genetics and Genomics Biomedicine Brazil Cancer Research Disease Disease susceptibility Electrophoresis, Agar Gel Gene Frequency Gene Function Genetic aspects Genetic Predisposition to Disease - genetics Genetics Genome-Wide Association Study Genotype Geography Haplotypes Haplotypes - genetics Health aspects HLA-DQ alpha-Chains - genetics HLA-DRB1 Chains - genetics Human Genetics Humans Identification and classification India Kala-azar Leishmaniasis, Visceral - genetics letter Linear Models Methods Odds Ratio Oligonucleotide Array Sequence Analysis Parasites Parasitic diseases Polymorphism, Single Nucleotide - genetics Quality control Quantitative trait loci Risk factors Studies Tropical diseases Vector-borne diseases
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