Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution
The role of natural killer (NK) cells in both immunity to infection and reproductive success is postulated to have placed competing demands on the evolution of NK cell receptors and their MHC class I ligands during the migration of humans out of Africa. Natural killer (NK) cells have roles in immuni...
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| Veröffentlicht in: | Nature reviews. Immunology 2013-02, Vol.13 (2), p.133-144 |
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| description | The role of natural killer (NK) cells in both immunity to infection and reproductive success is postulated to have placed competing demands on the evolution of NK cell receptors and their MHC class I ligands during the migration of humans out of Africa.
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the
MHC-C
gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents. |
| doi_str_mv | 10.1038/nri3370 |
| format | Article |
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Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the
MHC-C
gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.</description><identifier>ISSN: 1474-1733</identifier><identifier>EISSN: 1474-1741</identifier><identifier>DOI: 10.1038/nri3370</identifier><identifier>PMID: 23334245</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/181 ; 631/250/21/324/1509 ; 631/443/494 ; Animals ; Biological Evolution ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Cell migration ; Cell receptors ; Continents ; Evolution ; Evolution, Molecular ; Evolutionary genetics ; Genetic aspects ; Haplotypes ; Histocompatibility Antigens Class I - genetics ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class I - metabolism ; Human evolution ; Humans ; Immunity ; Immunity - genetics ; Immunity - immunology ; Immunology ; Killer cells ; Major histocompatibility complex ; Migration ; Natural killer cells ; opinion-2 ; Pan troglodytes ; Physiological aspects ; Primates ; Protein Binding ; Protein Stability ; Receptors, Natural Killer Cell - genetics ; Receptors, Natural Killer Cell - immunology ; Receptors, Natural Killer Cell - metabolism ; Reproduction ; Reproduction - genetics ; Reproduction - immunology</subject><ispartof>Nature reviews. Immunology, 2013-02, Vol.13 (2), p.133-144</ispartof><rights>Springer Nature Limited 2013</rights><rights>COPYRIGHT 2013 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c572t-dc2d50d8c4d8771309efdfa85d761efb69689b78018385f8518c7919f737cf293</citedby><cites>FETCH-LOGICAL-c572t-dc2d50d8c4d8771309efdfa85d761efb69689b78018385f8518c7919f737cf293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nri3370$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nri3370$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23334245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parham, Peter</creatorcontrib><creatorcontrib>Moffett, Ashley</creatorcontrib><title>Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution</title><title>Nature reviews. Immunology</title><addtitle>Nat Rev Immunol</addtitle><addtitle>Nat Rev Immunol</addtitle><description>The role of natural killer (NK) cells in both immunity to infection and reproductive success is postulated to have placed competing demands on the evolution of NK cell receptors and their MHC class I ligands during the migration of humans out of Africa.
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the
MHC-C
gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.</description><subject>631/181</subject><subject>631/250/21/324/1509</subject><subject>631/443/494</subject><subject>Animals</subject><subject>Biological Evolution</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Cell migration</subject><subject>Cell receptors</subject><subject>Continents</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Evolutionary genetics</subject><subject>Genetic aspects</subject><subject>Haplotypes</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>Histocompatibility Antigens Class I - immunology</subject><subject>Histocompatibility Antigens Class I - metabolism</subject><subject>Human evolution</subject><subject>Humans</subject><subject>Immunity</subject><subject>Immunity - genetics</subject><subject>Immunity - immunology</subject><subject>Immunology</subject><subject>Killer cells</subject><subject>Major histocompatibility complex</subject><subject>Migration</subject><subject>Natural killer cells</subject><subject>opinion-2</subject><subject>Pan troglodytes</subject><subject>Physiological aspects</subject><subject>Primates</subject><subject>Protein Binding</subject><subject>Protein Stability</subject><subject>Receptors, Natural Killer Cell - genetics</subject><subject>Receptors, Natural Killer Cell - immunology</subject><subject>Receptors, Natural Killer Cell - metabolism</subject><subject>Reproduction</subject><subject>Reproduction - genetics</subject><subject>Reproduction - immunology</subject><issn>1474-1733</issn><issn>1474-1741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl1vFCEUhonR2Loa_4EhMfEjcRUGZoDLZlPtxqqJX7eE5WOXZga2wJj238vYte32qlcQ3ue8h_fkAPAco_cYEf4hJE8IQw_AIaaMzjGj-OH1nZAD8CTnM4RwV5XH4KAhhNCGtofA_VbJq1Vv4dfPUNu-h8lquy0xZaiCgWVjfYJfThZQ9ypnuIS9X1chQx-gH4Yx-HL5rhZtUzSjLj6Gf3WbcVAB2j-xH6e3p-CRU322z3bnDPz6ePxzcTI__fZpuTg6neuWNWVudGNaZLimhjOGCRLWGad4a1iHrVt1ouNixTjCnPDW8RZzzQQWjhGmXSPIDLy58q3fOR9tLnLweYqlgo1jlrgRdQYUi-5-KKq9mnugvEEUU0Qq-vIOehbHFGrmiWpxy0RLb6i16q30wcWSlJ5M5RHBnArSVbMZeLtH6RiKvShrNeYslz--77OvbrEbq_qyybvh533w9RWoU8w5WSe3yQ8qXUqM5LRLcrdLlXyxizKuBmuuuf_LczOWXKWwtulW1jtefwF7S8wr</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Parham, Peter</creator><creator>Moffett, Ashley</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QR</scope><scope>7RV</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution</title><author>Parham, Peter ; Moffett, Ashley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c572t-dc2d50d8c4d8771309efdfa85d761efb69689b78018385f8518c7919f737cf293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/181</topic><topic>631/250/21/324/1509</topic><topic>631/443/494</topic><topic>Animals</topic><topic>Biological Evolution</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Cell migration</topic><topic>Cell receptors</topic><topic>Continents</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Evolutionary genetics</topic><topic>Genetic aspects</topic><topic>Haplotypes</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>Histocompatibility Antigens Class I - immunology</topic><topic>Histocompatibility Antigens Class I - metabolism</topic><topic>Human evolution</topic><topic>Humans</topic><topic>Immunity</topic><topic>Immunity - genetics</topic><topic>Immunity - immunology</topic><topic>Immunology</topic><topic>Killer cells</topic><topic>Major histocompatibility complex</topic><topic>Migration</topic><topic>Natural killer cells</topic><topic>opinion-2</topic><topic>Pan troglodytes</topic><topic>Physiological aspects</topic><topic>Primates</topic><topic>Protein Binding</topic><topic>Protein Stability</topic><topic>Receptors, Natural Killer Cell - genetics</topic><topic>Receptors, Natural Killer Cell - immunology</topic><topic>Receptors, Natural Killer Cell - metabolism</topic><topic>Reproduction</topic><topic>Reproduction - genetics</topic><topic>Reproduction - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parham, Peter</creatorcontrib><creatorcontrib>Moffett, Ashley</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parham, Peter</au><au>Moffett, Ashley</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution</atitle><jtitle>Nature reviews. Immunology</jtitle><stitle>Nat Rev Immunol</stitle><addtitle>Nat Rev Immunol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>13</volume><issue>2</issue><spage>133</spage><epage>144</epage><pages>133-144</pages><issn>1474-1733</issn><eissn>1474-1741</eissn><abstract>The role of natural killer (NK) cells in both immunity to infection and reproductive success is postulated to have placed competing demands on the evolution of NK cell receptors and their MHC class I ligands during the migration of humans out of Africa.
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by variable receptors that recognize MHC class I molecules. The variable NK cell receptors found in humans are specific to simian primates, in which they have progressively co-evolved with MHC class I molecules. The emergence of the
MHC-C
gene in hominids drove the evolution of a system of NK cell receptors for MHC-C molecules that is most elaborate in chimpanzees. By contrast, the human system of MHC-C receptors seems to have been subject to different selection pressures that have acted in competition on the immunological and reproductive functions of MHC class I molecules. We suggest that this compromise facilitated the development of the bigger brains that enabled archaic and modern humans to migrate out of Africa and populate other continents.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23334245</pmid><doi>10.1038/nri3370</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/181 631/250/21/324/1509 631/443/494 Animals Biological Evolution Biomedical and Life Sciences Biomedicine Brain Cell migration Cell receptors Continents Evolution Evolution, Molecular Evolutionary genetics Genetic aspects Haplotypes Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Human evolution Humans Immunity Immunity - genetics Immunity - immunology Immunology Killer cells Major histocompatibility complex Migration Natural killer cells opinion-2 Pan troglodytes Physiological aspects Primates Protein Binding Protein Stability Receptors, Natural Killer Cell - genetics Receptors, Natural Killer Cell - immunology Receptors, Natural Killer Cell - metabolism Reproduction Reproduction - genetics Reproduction - immunology |
| title | Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution |
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