De novo creation of MG1655-derived E. coli strains specifically designed for plasmid DNA production

The interest in plasmid DNA (pDNA) as a biopharmaceutical has been increasing over the last several years, especially after the approval of the first DNA vaccines. New pDNA production strains have been created by rationally mutating genes selected on the basis of Escherichia coli central metabolism...

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Veröffentlicht in:	Applied microbiology and biotechnology 2013, Vol.97 (2), p.611-620
Hauptverfasser:	Gonçalves, Geisa A. L., Prazeres, Duarte M. F., Monteiro, Gabriel A., Prather, Kristala L. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioengineering Biological products Biomedical and Life Sciences Biotechnological Products and Process Engineering Biotechnology Carbon Chemical engineering Clinical trials Deoxyribonucleic acid DNA E coli Escherichia coli Escherichia coli - genetics Fermentation Gene therapy Genetic engineering Glucose Glycerol Life Sciences Metabolic Engineering - methods Metabolism Microbial Genetics and Genomics Microbiology Mutation Pharmaceuticals Plasmids Plasmids - biosynthesis Plasmids - genetics Studies Vaccines Vaccines, DNA - genetics
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