An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development

Interleukin 7 (IL-7) signaling is essential during early lymphocyte development. Patra and colleagues identify a distinct IL-7–kinase Jak3–dependent pathway that activates the transcription factor NFATc1 in DN1 thymocytes to promote their survival. Interleukin 7 (IL-7) has a critical role in the dev...

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Veröffentlicht in:	Nature immunology 2013-02, Vol.14 (2), p.127-135
Hauptverfasser:	Patra, Amiya K, Avots, Andris, Zahedi, René P, Schüler, Thomas, Sickmann, Albert, Bommhardt, Ursula, Serfling, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516 Animals Biomedicine CD4 Antigens - genetics CD4 Antigens - immunology CD8 Antigens - genetics CD8 Antigens - immunology Cell Differentiation Gene Expression Regulation Genetic aspects Immunology Infectious Diseases Interleukin-7 Interleukin-7 - genetics Interleukin-7 - immunology Janus Kinase 3 - genetics Janus Kinase 3 - immunology Lymphopenia - immunology Lymphopenia - pathology Mice Mice, Transgenic NFATC Transcription Factors - deficiency NFATC Transcription Factors - genetics Phosphorylation Physiological aspects Promoter Regions, Genetic Receptors, Interleukin-7 - genetics Receptors, Interleukin-7 - immunology Signal Transduction - immunology STAT5 Transcription Factor - genetics STAT5 Transcription Factor - immunology Thymocytes - cytology Thymocytes - immunology Thymus Transcription, Genetic
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