Treatment In vitro of Retinal Cells with IL-4 Increases the Survival of Retinal Ganglion Cells: The Involvement of BDNF

Interleukin 4 (IL-4) is a pleiotropic cytokine involved in many functions during the development as well as in adult life. Previous work from our group demonstrated, in vitro, that this interleukin is able to prevent rat retinal ganglion cells death after axotomy. The aim of the present study was to...

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Veröffentlicht in:	Neurochemical research 2013, Vol.38 (1), p.162-173
Hauptverfasser:	de Araujo-Martins, Leandro, de Oliveira, Raphael Monteiro, dos Santos, Gabriela Velozo Gomes, dos Santos, Renata Cláudia Celestino, dos Santos, Aline Araujo, Giestal de Araujo, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Axotomy Biochemistry Biomedical and Life Sciences Biomedicine Blotting, Western Brain-Derived Neurotrophic Factor - physiology Cell Biology Cell Count Cell Survival - drug effects Cells, Cultured Cyclic AMP - physiology Cyclic AMP Response Element-Binding Protein - metabolism Enzyme Activation - drug effects Enzyme Activation - physiology Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Interleukin-4 - pharmacology Mitogen-Activated Protein Kinases - physiology Neurochemistry Neurology Neurosciences Original Paper Phosphorylation - physiology Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Rats Retina - cytology Retina - drug effects Retina - transplantation Retinal Ganglion Cells - drug effects Signal Transduction - drug effects
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