ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system

ARIH2 is a RING-between-RING E3 ligase. Pellegrini and colleagues show that ARIH2 is needed to limit excessive NF-κB signaling in DCs. Loss of ARIH2 is associated with embryonic death due to excessive inflammatory responses. The E3 ligase ARIH2 has an unusual structure and mechanism of elongating ub...

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Veröffentlicht in:	Nature immunology 2013-01, Vol.14 (1), p.27-33
Hauptverfasser:	Lin, Amy E, Ebert, Gregor, Ow, Yongkai, Preston, Simon P, Toe, Jesse G, Cooney, James P, Scott, Hamish W, Sasaki, Masato, Saibil, Samuel D, Dissanayake, Dilan, Kim, Raymond H, Wakeham, Andrew, You-Ten, Annick, Shahinian, Arda, Duncan, Gordon, Silvester, Jennifer, Ohashi, Pamela S, Mak, Tak W, Pellegrini, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/249/2510 631/250/2504/133 631/250/516/1909 Animals Biomedicine Cells, Cultured Dendritic Cells - immunology Disease Models, Animal Embryonic development Embryonic Development - genetics Embryonic Development - immunology Embryonic growth stage Genetic aspects Health aspects Hematopoiesis - genetics Hematopoietic stem cells Humans Immune system Immune System - physiology Immunology Infectious Diseases Mice Mice, Inbred C57BL Mice, Knockout Molecular Targeted Therapy Multiple Organ Failure - genetics Multiple Organ Failure - immunology NF-kappa B - metabolism Physiological aspects Physiology Stem cells Structure Transcriptional Activation - immunology Ubiquitin Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology Ubiquitination - genetics Ubiquitination - immunology
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