Efficacy of Adoptive Cell Transfer of Tumor-infiltrating Lymphocytes After Lymphopenia Induction for Metastatic Melanoma

A single-institution pilot clinical trial was performed combining nonmyeloablative chemotherapy and the adoptive transfer of tumor-infiltrating lymphocytes with interleukin-2 in patients with metastatic melanoma. Nineteen patients were enrolled with 13 patients (68%) successfully completing treatmen...

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Veröffentlicht in:	Journal of immunotherapy (1997) 2012-10, Vol.35 (8), p.615-620
Hauptverfasser:	PILON-THOMAS, Shari, KUHN, Lisa, WEBER, Jeffrey, MULE, James J, SARNAIK, Amod A, ELLWANGER, Sabine, JANSSEN, William, ROYSTER, Erica, MARZBAN, Suroosh, KUDCHADKAR, Ragini, ZAGER, Jonathan, GIBNEY, Geoffrey, SONDAK, Vernon K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic agents Biological and medical sciences Cyclophosphamide - administration & dosage Dermatology Female Follow-Up Studies Hematologic and hematopoietic diseases Humans Immunotherapy Immunotherapy, Adoptive - methods Interleukin-2 - administration & dosage Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - transplantation Lymphopenia - chemically induced Male Medical sciences Melanoma - immunology Melanoma - secondary Melanoma - therapy Middle Aged Other diseases. Hematologic involvement in other diseases Pharmacology. Drug treatments Pilot Projects Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - therapy Treatment Outcome Tumor Cells, Cultured Tumors of the skin and soft tissue. Premalignant lesions Vidarabine - administration & dosage Vidarabine - analogs & derivatives
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