Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody
► Catheterized guinea pigs can be used successfully at high containment. ► Catheterization reduces the requirement for sharps. ► Simultaneous blood samples can easily be collected from guinea pigs. ► Ebola virus infection had no effect on decay profile of a PS-targeting antibody. Sequential sampling...
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| Veröffentlicht in: | Antiviral research 2013-02, Vol.97 (2), p.108-111 |
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| creator | Dowall, Stuart Taylor, Irene Yeates, Paul Smith, Leonie Rule, Antony Easterbrook, Linda Bruce, Christine Cook, Nicola Corbin-Lickfett, Kara Empig, Cyril Schlunegger, Kyle Graham, Victoria Dennis, Mike Hewson, Roger |
| description | ► Catheterized guinea pigs can be used successfully at high containment. ► Catheterization reduces the requirement for sharps. ► Simultaneous blood samples can easily be collected from guinea pigs. ► Ebola virus infection had no effect on decay profile of a PS-targeting antibody.
Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody. |
| doi_str_mv | 10.1016/j.antiviral.2012.11.003 |
| format | Article |
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Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.</description><identifier>ISSN: 0166-3542</identifier><identifier>EISSN: 1872-9096</identifier><identifier>DOI: 10.1016/j.antiviral.2012.11.003</identifier><identifier>PMID: 23165089</identifier><identifier>CODEN: ARSRDR</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animal models ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - pharmacokinetics ; Antiviral agents ; Biological and medical sciences ; Catheterized ; Data processing ; Disease Models, Animal ; Ebola ; Ebola virus ; Ebolavirus - pathogenicity ; Guinea Pigs ; Hemorrhagic fever ; Hemorrhagic Fever, Ebola - therapy ; Immunologic Factors - administration & dosage ; Immunologic Factors - pharmacokinetics ; Infection ; Medical sciences ; Monoclonal antibodies ; Pharmaceuticals ; Pharmacokinetic ; Pharmacokinetics ; Pharmacology. Drug treatments ; Phosphatidylserines - antagonists & inhibitors ; Sampling</subject><ispartof>Antiviral research, 2013-02, Vol.97 (2), p.108-111</ispartof><rights>2012 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-9fe96788013f85c7e41feef32dc81fbb7064da83341eebabd686204f9dfbfaca3</citedby><cites>FETCH-LOGICAL-c434t-9fe96788013f85c7e41feef32dc81fbb7064da83341eebabd686204f9dfbfaca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166354212002586$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26904514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23165089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dowall, Stuart</creatorcontrib><creatorcontrib>Taylor, Irene</creatorcontrib><creatorcontrib>Yeates, Paul</creatorcontrib><creatorcontrib>Smith, Leonie</creatorcontrib><creatorcontrib>Rule, Antony</creatorcontrib><creatorcontrib>Easterbrook, Linda</creatorcontrib><creatorcontrib>Bruce, Christine</creatorcontrib><creatorcontrib>Cook, Nicola</creatorcontrib><creatorcontrib>Corbin-Lickfett, Kara</creatorcontrib><creatorcontrib>Empig, Cyril</creatorcontrib><creatorcontrib>Schlunegger, Kyle</creatorcontrib><creatorcontrib>Graham, Victoria</creatorcontrib><creatorcontrib>Dennis, Mike</creatorcontrib><creatorcontrib>Hewson, Roger</creatorcontrib><title>Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody</title><title>Antiviral research</title><addtitle>Antiviral Res</addtitle><description>► Catheterized guinea pigs can be used successfully at high containment. ► Catheterization reduces the requirement for sharps. ► Simultaneous blood samples can easily be collected from guinea pigs. ► Ebola virus infection had no effect on decay profile of a PS-targeting antibody.
Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.</description><subject>Animal models</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. 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Sequential sampling from animals challenged with highly pathogenic organisms, such as haemorrhagic fever viruses, is required for many pharmaceutical studies. Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Levels of a PS-targeting antibody (Bavituximab) were measured in Ebola-infected animals and uninfected controls. Data showed that the pharmacokinetics were similar in both groups, therefore Ebola virus infection did not have an observable effect on the half-life of the antibody.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>23165089</pmid><doi>10.1016/j.antiviral.2012.11.003</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0166-3542 |
| ispartof | Antiviral research, 2013-02, Vol.97 (2), p.108-111 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal models Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacokinetics Antiviral agents Biological and medical sciences Catheterized Data processing Disease Models, Animal Ebola Ebola virus Ebolavirus - pathogenicity Guinea Pigs Hemorrhagic fever Hemorrhagic Fever, Ebola - therapy Immunologic Factors - administration & dosage Immunologic Factors - pharmacokinetics Infection Medical sciences Monoclonal antibodies Pharmaceuticals Pharmacokinetic Pharmacokinetics Pharmacology. Drug treatments Phosphatidylserines - antagonists & inhibitors Sampling |
| title | Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody |
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