Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers
Purpose: To investigate the detectability of hepatocellular carcinoma (HCC) on Gd‐EOB‐enhanced MR images (Gd‐EOB‐MRI), we performed tumor‐by‐tumor analysis of pathologically confirmed tumors using explants from cirrhotic patients who had undergone liver transplantation. Materials and Methods: We stu...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2013-03, Vol.37 (3), p.684-691 |
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| creator | Nakamura, Yuko Tashiro, Hirotaka Nambu, Junko Ohdan, Hideki Kakizawa, Hideaki Date, Shuji Awai, Kazuo |
| description | Purpose:
To investigate the detectability of hepatocellular carcinoma (HCC) on Gd‐EOB‐enhanced MR images (Gd‐EOB‐MRI), we performed tumor‐by‐tumor analysis of pathologically confirmed tumors using explants from cirrhotic patients who had undergone liver transplantation.
Materials and Methods:
We studied 11 explanted livers and classified the tumor intensity during the arterial phase (AP) and the hepatobiliary phase (HBP) as low in HBP with early enhancement (EE) in AP (A), as high in HBP with EE in AP (B), as low in HBP without EE in AP (C), as high in HBP without EE in AP (D), and as iso‐intense in HBP with EE in AP (E). The diagnostic criteria for HCC were (i) pattern A and C, (ii) pattern A and E, (iii) pattern C and E, and (iv) patterns A, C, and E.
Results:
Of the 71 HCCs, 22 were not detected at MRI; of these, 9 were moderately differentiated and 13 were well‐differentiated HCCs. The sensitivity of Gd‐EOB‐MRI for diagnostic criteria 1, 2, 3, and 4 was 63.4%, 52.1%, 22.5%, and 69.0%.
Conclusion:
The maximum sensitivity of Gd‐EOB‐MRI for HCC was only 69.0% even when diagnostic criteria that included all previously reported HCC patterns were adopted. J. Magn. Reson. Imaging 2013;37:684—691. © 2012 Wiley Perioidicals, Inc. |
| doi_str_mv | 10.1002/jmri.23855 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1291604872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2895032841</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4975-b5f393a1e50734413b57a2c82a70ad55b0bb42aaac52a385b3e6da67b03168da3</originalsourceid><addsrcrecordid>eNp9kUtv1TAUhCMEog_Y8AOQJTYIKcWPOE7YVS20RS2IqtCldeycS31J4ovtlJsdP52EtF2wYHVm8c1IcybLXjB6wCjlb9ddcAdcVFI-ynaZ5DznsiofT5pKkbOKqp1sL8Y1pbSuC_k02-GCSlmIcjf7fYwJbQLjWpdG4lfkBjeQvMW2HVoIxEKwrvcdEDOS79D4LSZISBoXfeOGLsf-BnqLzWJ0llxcnr0jV0PnQ27GPM2CQA_tGF0krie43bTQJ9K6WwzxWfZkBW3E53d3P_v64f3V0Wl-_vnk7OjwPLdFrWRu5ErUAhhKqkRRMGGkAm4rDopCI6WhxhQcAKzkML3CCCwbKJWhgpVVA2I_e73kboL_OWBMunNxbgk9-iFqxmtW0qJSfEJf_YOu_RCmBjNVVUrUXLGJerNQNvgYA670JrgOwqgZ1fMuet5F_91lgl_eRQ6mw-YBvR9iAtgC_HItjv-J0h-n_96H5ovHxYTbBw-EH7pUQkl9_elEfyuPLy9Oyy_6WvwBEOepDg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1288739271</pqid></control><display><type>article</type><title>Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Nakamura, Yuko ; Tashiro, Hirotaka ; Nambu, Junko ; Ohdan, Hideki ; Kakizawa, Hideaki ; Date, Shuji ; Awai, Kazuo</creator><creatorcontrib>Nakamura, Yuko ; Tashiro, Hirotaka ; Nambu, Junko ; Ohdan, Hideki ; Kakizawa, Hideaki ; Date, Shuji ; Awai, Kazuo</creatorcontrib><description>Purpose:
To investigate the detectability of hepatocellular carcinoma (HCC) on Gd‐EOB‐enhanced MR images (Gd‐EOB‐MRI), we performed tumor‐by‐tumor analysis of pathologically confirmed tumors using explants from cirrhotic patients who had undergone liver transplantation.
Materials and Methods:
We studied 11 explanted livers and classified the tumor intensity during the arterial phase (AP) and the hepatobiliary phase (HBP) as low in HBP with early enhancement (EE) in AP (A), as high in HBP with EE in AP (B), as low in HBP without EE in AP (C), as high in HBP without EE in AP (D), and as iso‐intense in HBP with EE in AP (E). The diagnostic criteria for HCC were (i) pattern A and C, (ii) pattern A and E, (iii) pattern C and E, and (iv) patterns A, C, and E.
Results:
Of the 71 HCCs, 22 were not detected at MRI; of these, 9 were moderately differentiated and 13 were well‐differentiated HCCs. The sensitivity of Gd‐EOB‐MRI for diagnostic criteria 1, 2, 3, and 4 was 63.4%, 52.1%, 22.5%, and 69.0%.
Conclusion:
The maximum sensitivity of Gd‐EOB‐MRI for HCC was only 69.0% even when diagnostic criteria that included all previously reported HCC patterns were adopted. J. Magn. Reson. Imaging 2013;37:684—691. © 2012 Wiley Perioidicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.23855</identifier><identifier>PMID: 23055436</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Cell Differentiation ; Contrast Media - pharmacology ; explant livers ; Female ; Gadolinium DTPA - pharmacology ; gadoxetate disodium ; HCC ; Humans ; Liver - pathology ; Liver Cirrhosis - pathology ; liver MRI ; Liver Neoplasms - diagnosis ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Tomography, X-Ray Computed - methods</subject><ispartof>Journal of magnetic resonance imaging, 2013-03, Vol.37 (3), p.684-691</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4975-b5f393a1e50734413b57a2c82a70ad55b0bb42aaac52a385b3e6da67b03168da3</citedby><cites>FETCH-LOGICAL-c4975-b5f393a1e50734413b57a2c82a70ad55b0bb42aaac52a385b3e6da67b03168da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.23855$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.23855$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23055436$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakamura, Yuko</creatorcontrib><creatorcontrib>Tashiro, Hirotaka</creatorcontrib><creatorcontrib>Nambu, Junko</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><creatorcontrib>Kakizawa, Hideaki</creatorcontrib><creatorcontrib>Date, Shuji</creatorcontrib><creatorcontrib>Awai, Kazuo</creatorcontrib><title>Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To investigate the detectability of hepatocellular carcinoma (HCC) on Gd‐EOB‐enhanced MR images (Gd‐EOB‐MRI), we performed tumor‐by‐tumor analysis of pathologically confirmed tumors using explants from cirrhotic patients who had undergone liver transplantation.
Materials and Methods:
We studied 11 explanted livers and classified the tumor intensity during the arterial phase (AP) and the hepatobiliary phase (HBP) as low in HBP with early enhancement (EE) in AP (A), as high in HBP with EE in AP (B), as low in HBP without EE in AP (C), as high in HBP without EE in AP (D), and as iso‐intense in HBP with EE in AP (E). The diagnostic criteria for HCC were (i) pattern A and C, (ii) pattern A and E, (iii) pattern C and E, and (iv) patterns A, C, and E.
Results:
Of the 71 HCCs, 22 were not detected at MRI; of these, 9 were moderately differentiated and 13 were well‐differentiated HCCs. The sensitivity of Gd‐EOB‐MRI for diagnostic criteria 1, 2, 3, and 4 was 63.4%, 52.1%, 22.5%, and 69.0%.
Conclusion:
The maximum sensitivity of Gd‐EOB‐MRI for HCC was only 69.0% even when diagnostic criteria that included all previously reported HCC patterns were adopted. J. Magn. Reson. Imaging 2013;37:684—691. © 2012 Wiley Perioidicals, Inc.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Cell Differentiation</subject><subject>Contrast Media - pharmacology</subject><subject>explant livers</subject><subject>Female</subject><subject>Gadolinium DTPA - pharmacology</subject><subject>gadoxetate disodium</subject><subject>HCC</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - pathology</subject><subject>liver MRI</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1TAUhCMEog_Y8AOQJTYIKcWPOE7YVS20RS2IqtCldeycS31J4ovtlJsdP52EtF2wYHVm8c1IcybLXjB6wCjlb9ddcAdcVFI-ynaZ5DznsiofT5pKkbOKqp1sL8Y1pbSuC_k02-GCSlmIcjf7fYwJbQLjWpdG4lfkBjeQvMW2HVoIxEKwrvcdEDOS79D4LSZISBoXfeOGLsf-BnqLzWJ0llxcnr0jV0PnQ27GPM2CQA_tGF0krie43bTQJ9K6WwzxWfZkBW3E53d3P_v64f3V0Wl-_vnk7OjwPLdFrWRu5ErUAhhKqkRRMGGkAm4rDopCI6WhxhQcAKzkML3CCCwbKJWhgpVVA2I_e73kboL_OWBMunNxbgk9-iFqxmtW0qJSfEJf_YOu_RCmBjNVVUrUXLGJerNQNvgYA670JrgOwqgZ1fMuet5F_91lgl_eRQ6mw-YBvR9iAtgC_HItjv-J0h-n_96H5ovHxYTbBw-EH7pUQkl9_elEfyuPLy9Oyy_6WvwBEOepDg</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Nakamura, Yuko</creator><creator>Tashiro, Hirotaka</creator><creator>Nambu, Junko</creator><creator>Ohdan, Hideki</creator><creator>Kakizawa, Hideaki</creator><creator>Date, Shuji</creator><creator>Awai, Kazuo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers</title><author>Nakamura, Yuko ; Tashiro, Hirotaka ; Nambu, Junko ; Ohdan, Hideki ; Kakizawa, Hideaki ; Date, Shuji ; Awai, Kazuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4975-b5f393a1e50734413b57a2c82a70ad55b0bb42aaac52a385b3e6da67b03168da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Cell Differentiation</topic><topic>Contrast Media - pharmacology</topic><topic>explant livers</topic><topic>Female</topic><topic>Gadolinium DTPA - pharmacology</topic><topic>gadoxetate disodium</topic><topic>HCC</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - pathology</topic><topic>liver MRI</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakamura, Yuko</creatorcontrib><creatorcontrib>Tashiro, Hirotaka</creatorcontrib><creatorcontrib>Nambu, Junko</creatorcontrib><creatorcontrib>Ohdan, Hideki</creatorcontrib><creatorcontrib>Kakizawa, Hideaki</creatorcontrib><creatorcontrib>Date, Shuji</creatorcontrib><creatorcontrib>Awai, Kazuo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakamura, Yuko</au><au>Tashiro, Hirotaka</au><au>Nambu, Junko</au><au>Ohdan, Hideki</au><au>Kakizawa, Hideaki</au><au>Date, Shuji</au><au>Awai, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2013-03</date><risdate>2013</risdate><volume>37</volume><issue>3</issue><spage>684</spage><epage>691</epage><pages>684-691</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To investigate the detectability of hepatocellular carcinoma (HCC) on Gd‐EOB‐enhanced MR images (Gd‐EOB‐MRI), we performed tumor‐by‐tumor analysis of pathologically confirmed tumors using explants from cirrhotic patients who had undergone liver transplantation.
Materials and Methods:
We studied 11 explanted livers and classified the tumor intensity during the arterial phase (AP) and the hepatobiliary phase (HBP) as low in HBP with early enhancement (EE) in AP (A), as high in HBP with EE in AP (B), as low in HBP without EE in AP (C), as high in HBP without EE in AP (D), and as iso‐intense in HBP with EE in AP (E). The diagnostic criteria for HCC were (i) pattern A and C, (ii) pattern A and E, (iii) pattern C and E, and (iv) patterns A, C, and E.
Results:
Of the 71 HCCs, 22 were not detected at MRI; of these, 9 were moderately differentiated and 13 were well‐differentiated HCCs. The sensitivity of Gd‐EOB‐MRI for diagnostic criteria 1, 2, 3, and 4 was 63.4%, 52.1%, 22.5%, and 69.0%.
Conclusion:
The maximum sensitivity of Gd‐EOB‐MRI for HCC was only 69.0% even when diagnostic criteria that included all previously reported HCC patterns were adopted. J. Magn. Reson. Imaging 2013;37:684—691. © 2012 Wiley Perioidicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23055436</pmid><doi>10.1002/jmri.23855</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cell Differentiation Contrast Media - pharmacology explant livers Female Gadolinium DTPA - pharmacology gadoxetate disodium HCC Humans Liver - pathology Liver Cirrhosis - pathology liver MRI Liver Neoplasms - diagnosis Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Reproducibility of Results Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed - methods |
| title | Detectability of hepatocellular carcinoma by gadoxetate disodium-enhanced hepatic MRI: Tumor-by-tumor analysis in explant livers |
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