Poly(I:C) combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs

► Developing a multi-epitope vaccine for FMD with optimal immunogenicity. ► Combination poly(I:C) with this vaccine conferred 100% protection in pigs. ► Poly(I:C) up-regulated T-cell immunity in pigs. ► Poly(I:C) is an effective adjuvant for this epitope-based vaccine of FMDV. We designed a series o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antiviral research 2013-02, Vol.97 (2), p.145-153
Hauptverfasser:	Cao, Yimei, Lu, Zengjun, Li, Yanli, Sun, Pu, Li, Dong, Li, Pinghua, Bai, Xingwen, Fu, Yuanfang, Bao, Huifang, Zhou, Chunxue, Xie, Baoxia, Chen, Yingli, Liu, Zaixin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage alpha -Interferon Animal viral diseases Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Neutralizing - blood Antibodies, Viral - blood Antiviral agents beta -Interferon Biological and medical sciences Combined vaccines Cross-reactivity Epitopes Epitopes - genetics Epitopes - immunology FMDV Foot-and-mouth disease Foot-and-Mouth Disease - immunology Foot-and-Mouth Disease - prevention & control Foot-and-mouth disease virus Foot-and-Mouth Disease Virus - immunology gamma -Interferon Immunity Immunogenicity Immunoglobulin G Infectious diseases Injections, Intramuscular Inoculation Interferon-alpha - secretion Interferon-beta - secretion Interferon-gamma - secretion Lymphocytes T Medical sciences Multi-epitope protein vaccine Pharmacology. Drug treatments Pig Poly I-C - administration & dosage Poly(I:C) Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology Serotypes Swine Swine Diseases - immunology Swine Diseases - prevention & control Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Viral diseases Viral Vaccines - administration & dosage Viral Vaccines - genetics Viral Vaccines - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!