1,3,5-Triazine as a Modular Scaffold for Covalent Inhibitors with Streamlined Target Identification

Small-molecule inhibitors can accelerate the functional annotation and validate the therapeutic potential of proteins implicated in disease. Phenotypic screens provide an effective platform to identify such pharmacological agents but are often hindered by challenges associated with target identifica...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-02, Vol.135 (7), p.2497-2500
Hauptverfasser:	Banerjee, Ranjan, Pace, Nicholas J, Brown, Douglas R, Weerapana, Eranthie
Format:	Artikel
Sprache:	eng
Schlagworte:	Cysteine - antagonists & inhibitors Cysteine - chemistry Drug Delivery Systems Electrophoresis, Polyacrylamide Gel HeLa Cells Humans Proteins - antagonists & inhibitors Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Triazines - chemical synthesis Triazines - chemistry
Online-Zugang:	Volltext
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