Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease

Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. Previous studies in experimental animal models have reported that administrati...

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Veröffentlicht in:	Nature communications 2013-02, Vol.4 (1), p.1495-1495, Article 1495
Hauptverfasser:	Moreno-Gonzalez, Ines, Estrada, Lisbell D., Sanchez-Mejias, Elisabeth, Soto, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/1283 692/499 Alzheimer Disease - blood Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid - metabolism Amyloid beta-Peptides - metabolism Animals Cigarettes Cotinine - blood Disease Disease Models, Animal Glial Fibrillary Acidic Protein - metabolism Gliosis - metabolism Gliosis - pathology Humanities and Social Sciences Humans Mice Mice, Transgenic Microglia - metabolism Microglia - pathology multidisciplinary Nerve Degeneration - metabolism Nerve Degeneration - pathology Neuropathology Nicotine Older people Pathology Phosphorylation Plasma Presenilin-1 - metabolism Science Science (multidisciplinary) Smoke inhalation Smoking Smoking - metabolism Smoking - pathology tau Proteins - metabolism Tobacco smoke Transgenic animals
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