Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)3Cl2; the process is characterized by its ope...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-02, Vol.135 (7), p.2505-2508
Hauptverfasser:	Mizuta, Satoshi, Verhoog, Stefan, Engle, Keary M, Khotavivattana, Tanatorn, O’Duill, Miriam, Wheelhouse, Katherine, Rassias, Gerasimos, Médebielle, Maurice, Gouverneur, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Catalysis Fluorine - chemistry Methylation Molecular Structure
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creator	Mizuta, Satoshi Verhoog, Stefan Engle, Keary M Khotavivattana, Tanatorn O’Duill, Miriam Wheelhouse, Katherine Rassias, Gerasimos Médebielle, Maurice Gouverneur, Véronique
description	A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)3Cl2; the process is characterized by its operational simplicity and functional group tolerance.
doi_str_mv	10.1021/ja401022x
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subjects	Alkenes - chemistry Catalysis Fluorine - chemistry Methylation Molecular Structure
title	Catalytic Hydrotrifluoromethylation of Unactivated Alkenes
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