Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

Catalytic Hydrotrifluoromethylation of Unactivated Alkenes

A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)3Cl2; the process is characterized by its ope...

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Veröffentlicht in:Journal of the American Chemical Society 2013-02, Vol.135 (7), p.2505-2508
Hauptverfasser: Mizuta, Satoshi, Verhoog, Stefan, Engle, Keary M, Khotavivattana, Tanatorn, O’Duill, Miriam, Wheelhouse, Katherine, Rassias, Gerasimos, Médebielle, Maurice, Gouverneur, Véronique
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Catalysis
Fluorine - chemistry
Methylation
Molecular Structure
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Beschreibung
Zusammenfassung:A visible-light-mediated hydrotrifluoromethylation of unactivated alkenes that uses the Umemoto reagent as the CF3 source and MeOH as the reductant is disclosed. This effective transformation operates at room temperature in the presence of 5 mol % Ru(bpy)3Cl2; the process is characterized by its operational simplicity and functional group tolerance.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja401022x