Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae)
Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and su...
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| Veröffentlicht in: | Journal of ethnopharmacology 2013-03, Vol.146 (1), p.318-323 |
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| creator | Moreira, Jeverson Klein-Júnior, Luiz Carlos Filho, Valdir Cechinel Buzzi, Fátima de Campos |
| description | Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries.
This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09–13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15–22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3mg/kg.
The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
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| doi_str_mv | 10.1016/j.jep.2012.12.052 |
| format | Article |
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This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09–13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15–22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3mg/kg.
The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2012.12.052</identifier><identifier>PMID: 23333746</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Acetic Acid ; Analgesics - therapeutic use ; animal models ; Animals ; Antinociception ; aspirin ; Behavior, Animal - drug effects ; Capsaicin ; chromatography ; Corilagin ; Euphorbiaceae ; Formaldehyde ; formalin ; Glucosides - therapeutic use ; Glutamic Acid ; Hot Temperature ; Hydrolyzable Tannins ; Hyperalgesia - drug therapy ; Hyperalgesia - etiology ; Hyperalgesia - physiopathology ; Male ; Mice ; Motor Activity - drug effects ; nociception ; Phyllanthus ; Phyllanthus niruri ; Phyllanthus niruru L ; Phytotherapy</subject><ispartof>Journal of ethnopharmacology, 2013-03, Vol.146 (1), p.318-323</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-3572f653b9b315b7f5c6b1d141ebc50040398275e118bedab9ae13e945ada6a03</citedby><cites>FETCH-LOGICAL-c420t-3572f653b9b315b7f5c6b1d141ebc50040398275e118bedab9ae13e945ada6a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S037887411300010X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23333746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreira, Jeverson</creatorcontrib><creatorcontrib>Klein-Júnior, Luiz Carlos</creatorcontrib><creatorcontrib>Filho, Valdir Cechinel</creatorcontrib><creatorcontrib>Buzzi, Fátima de Campos</creatorcontrib><title>Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae)</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries.
This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09–13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15–22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3mg/kg.
The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
[Display omitted]</description><subject>Acetic Acid</subject><subject>Analgesics - therapeutic use</subject><subject>animal models</subject><subject>Animals</subject><subject>Antinociception</subject><subject>aspirin</subject><subject>Behavior, Animal - drug effects</subject><subject>Capsaicin</subject><subject>chromatography</subject><subject>Corilagin</subject><subject>Euphorbiaceae</subject><subject>Formaldehyde</subject><subject>formalin</subject><subject>Glucosides - therapeutic use</subject><subject>Glutamic Acid</subject><subject>Hot Temperature</subject><subject>Hydrolyzable Tannins</subject><subject>Hyperalgesia - drug therapy</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Male</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>nociception</subject><subject>Phyllanthus</subject><subject>Phyllanthus niruri</subject><subject>Phyllanthus niruru L</subject><subject>Phytotherapy</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpabZpf0AvrY4pxK4-LZucQkiTwkICbc5Ckse7WryWK8mB_ffVsmmPGQbm8rwvw4PQZ0pqSmjzfVfvYK4ZoawuSyR7g1a0VaxSUvG3aEW4aqtWCXqGPqS0I4QoKsh7dMZ4GSWaFYLrKftqe5ghmnEDyTtsXPbPPh9wGLAL0Y9m46dLbHA20-Qn7FMYTYYeDzHs8eP2MI5mytsl4cnHJXq8rvHF7TJvQ7TeODDw7SN6N5gxwaeXe46eftz-vrmv1g93P2-u15UTjOSKS8WGRnLbWU6lVYN0jaU9FRSsk4QIwruWKQmUthZ6YzsDlEMnpOlNYwg_Rxen3jmGPwukrPc-OTg-CGFJmrK2E61SrCsoPaEuhpQiDHqOfm_iQVOij3b1The7-mi35HSxWzJfXuoXu4f-f-KfzgJ8PQGDCdpsok_66VdpEEW9aMspxNWJgKLh2UPUyXmYHPQ-gsu6D_6VB_4CwLyTxw</recordid><startdate>20130307</startdate><enddate>20130307</enddate><creator>Moreira, Jeverson</creator><creator>Klein-Júnior, Luiz Carlos</creator><creator>Filho, Valdir Cechinel</creator><creator>Buzzi, Fátima de Campos</creator><general>Elsevier Ireland Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130307</creationdate><title>Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae)</title><author>Moreira, Jeverson ; Klein-Júnior, Luiz Carlos ; Filho, Valdir Cechinel ; Buzzi, Fátima de Campos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-3572f653b9b315b7f5c6b1d141ebc50040398275e118bedab9ae13e945ada6a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetic Acid</topic><topic>Analgesics - therapeutic use</topic><topic>animal models</topic><topic>Animals</topic><topic>Antinociception</topic><topic>aspirin</topic><topic>Behavior, Animal - drug effects</topic><topic>Capsaicin</topic><topic>chromatography</topic><topic>Corilagin</topic><topic>Euphorbiaceae</topic><topic>Formaldehyde</topic><topic>formalin</topic><topic>Glucosides - therapeutic use</topic><topic>Glutamic Acid</topic><topic>Hot Temperature</topic><topic>Hydrolyzable Tannins</topic><topic>Hyperalgesia - drug therapy</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Male</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>nociception</topic><topic>Phyllanthus</topic><topic>Phyllanthus niruri</topic><topic>Phyllanthus niruru L</topic><topic>Phytotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreira, Jeverson</creatorcontrib><creatorcontrib>Klein-Júnior, Luiz Carlos</creatorcontrib><creatorcontrib>Filho, Valdir Cechinel</creatorcontrib><creatorcontrib>Buzzi, Fátima de Campos</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreira, Jeverson</au><au>Klein-Júnior, Luiz Carlos</au><au>Filho, Valdir Cechinel</au><au>Buzzi, Fátima de Campos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae)</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2013-03-07</date><risdate>2013</risdate><volume>146</volume><issue>1</issue><spage>318</spage><epage>323</epage><pages>318-323</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from Phyllanthus niruri (Euphorbiaceae). This plant is well known for their therapeutic purposes to treat several diseases associated with dolorous process and are used in several ethno-medicines in tropical and subtropical countries.
This study was designed to evaluate the anti-hyperalgesic activity of corilagin using chemically and thermally based nociception models in mice.
Corilagin was isolated from Phyllanthus niruri (Euphorbiaceae) by extraction and chromatographic procedures and the anti-hyperalgesic activity was evaluated by using writhing, formalin, capsaicin, glutamate and hot plate tests in mice.
Corilagin presented activity in acetic acid model with the ID50 calculated value of 6.46 (3.09–13.51) being about 20.6 fold more potent than acetylsalicylic acid. It also exhibited activity against the first phase of formalin test with ID50 value of 18.38 (15.15–22.59) μmol/kg. In the capsaicin and glutamate models, corilagin demonstrated significant activity at the 3mg/kg.
The experimental data demonstrated that corilagin exhibits anti-hyperalgesic activity that may be due to interaction with the glutamatergic system.
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetic Acid Analgesics - therapeutic use animal models Animals Antinociception aspirin Behavior, Animal - drug effects Capsaicin chromatography Corilagin Euphorbiaceae Formaldehyde formalin Glucosides - therapeutic use Glutamic Acid Hot Temperature Hydrolyzable Tannins Hyperalgesia - drug therapy Hyperalgesia - etiology Hyperalgesia - physiopathology Male Mice Motor Activity - drug effects nociception Phyllanthus Phyllanthus niruri Phyllanthus niruru L Phytotherapy |
| title | Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae) |
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