Autocrine Endocannabinoid Signaling through CB1 Receptors Potentiates OX1 Orexin Receptor Signaling

It has been proposed that OX1 orexin receptors and CB1 cannabinoid receptors can form heteromeric complexes, which affect the trafficking of OX1 receptors and potentiate OX1 receptor signaling to extracellular signal–regulated kinase (ERK). We have recently shown that OX1 receptor activity releases...

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Veröffentlicht in:	Molecular pharmacology 2013-03, Vol.83 (3), p.621-632
Hauptverfasser:	Jäntti, Maria H., Putula, Jaana, Turunen, Pauli M., Näsman, Johnny, Reijonen, Sami, Lindqvist, Christer, Kukkonen, Jyrki P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acids - metabolism Autocrine Communication CHO Cells Cricetinae Endocannabinoids - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Glycerides - metabolism Humans Lipoprotein Lipase - antagonists & inhibitors Orexin Receptors Phosphorylation - physiology Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - metabolism Receptor, Muscarinic M1 - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Neuropeptide - metabolism Signal Transduction
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