Stem cell–based therapy for corneal epithelial reconstruction: present and future
Abstract Limbal stem cell deficiency is a painful and potentially blinding disease. Cultured limbal epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction with variable clinical success. This work summarizes recent developments and trends that have the potential...
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| Veröffentlicht in: | Canadian journal of ophthalmology 2013-02, Vol.48 (1), p.13-21 |
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| container_title | Canadian journal of ophthalmology |
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| creator | Menzel-Severing, Johannes, MD, MSc Kruse, Friedrich E., MD Schlötzer-Schrehardt, Ursula, PhD |
| description | Abstract Limbal stem cell deficiency is a painful and potentially blinding disease. Cultured limbal epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction with variable clinical success. This work summarizes recent developments and trends that have the potential to increase safety and efficacy of CLET in the future. Apart from gradual transition to xenobiotic-free culture systems, novel biofunctional scaffolds presenting components of stem cell microenvironments aim at promoting long-term maintenance of stem cells in vitro and after transplantation. Hair follicles and other tissues may serve as autologous sources of adult stem cells in bilateral ocular surface disease. However, despite all progress made in the fields of tissue engineering and cell therapy, it is unlikely that CLET will yield fully satisfactory clinical results until the factors that govern limbal stem cell maintenance and differentiation are identified. |
| doi_str_mv | 10.1016/j.jcjo.2012.11.009 |
| format | Article |
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Cultured limbal epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction with variable clinical success. This work summarizes recent developments and trends that have the potential to increase safety and efficacy of CLET in the future. Apart from gradual transition to xenobiotic-free culture systems, novel biofunctional scaffolds presenting components of stem cell microenvironments aim at promoting long-term maintenance of stem cells in vitro and after transplantation. Hair follicles and other tissues may serve as autologous sources of adult stem cells in bilateral ocular surface disease. However, despite all progress made in the fields of tissue engineering and cell therapy, it is unlikely that CLET will yield fully satisfactory clinical results until the factors that govern limbal stem cell maintenance and differentiation are identified.</description><identifier>ISSN: 0008-4182</identifier><identifier>EISSN: 1715-3360</identifier><identifier>DOI: 10.1016/j.jcjo.2012.11.009</identifier><identifier>PMID: 23419294</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Cell- and Tissue-Based Therapy ; Cells, Cultured ; Corneal Diseases - therapy ; Epithelium, Corneal - pathology ; Epithelium, Corneal - transplantation ; Humans ; Internal Medicine ; Limbus Corneae - cytology ; Ophthalmology ; Reconstructive Surgical Procedures ; Stem Cell Transplantation ; Tissue Engineering</subject><ispartof>Canadian journal of ophthalmology, 2013-02, Vol.48 (1), p.13-21</ispartof><rights>Canadian Ophthalmological Society</rights><rights>2013 Canadian Ophthalmological Society</rights><rights>Copyright © 2013 Canadian Ophthalmological Society. 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Cultured limbal epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction with variable clinical success. This work summarizes recent developments and trends that have the potential to increase safety and efficacy of CLET in the future. Apart from gradual transition to xenobiotic-free culture systems, novel biofunctional scaffolds presenting components of stem cell microenvironments aim at promoting long-term maintenance of stem cells in vitro and after transplantation. Hair follicles and other tissues may serve as autologous sources of adult stem cells in bilateral ocular surface disease. However, despite all progress made in the fields of tissue engineering and cell therapy, it is unlikely that CLET will yield fully satisfactory clinical results until the factors that govern limbal stem cell maintenance and differentiation are identified.</description><subject>Cell- and Tissue-Based Therapy</subject><subject>Cells, Cultured</subject><subject>Corneal Diseases - therapy</subject><subject>Epithelium, Corneal - pathology</subject><subject>Epithelium, Corneal - transplantation</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Limbus Corneae - cytology</subject><subject>Ophthalmology</subject><subject>Reconstructive Surgical Procedures</subject><subject>Stem Cell Transplantation</subject><subject>Tissue Engineering</subject><issn>0008-4182</issn><issn>1715-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQhy0EotvCC3BAOXJJ8J84iRFCQhWFSpV62HK2HHssHLJ2sB2kvfEOvCFPgsMWDj1wsmX95vPMNwi9ILghmHSvp2bSU2goJrQhpMFYPEI70hNeM9bhx2iHMR7qlgz0DJ2nNGHMWN92T9EZZS0RVLQ7tN9nOFQa5vnXj5-jSmCq_AWiWo6VDbHSIXpQcwWLK8-zK9cIOviU46qzC_5NtURI4HOlvKnsmtcIz9ATq-YEz-_PC_T56sPd5af65vbj9eX7m1qX73PNqRoNKMtKl8wANVp0SvDRCtoS3nfWdpppSwGUpqMYqBpaKrgRnAx8wIJdoFcn7hLDtxVSlgeXtlGUh7AmSegg2r4f2r5E6SmqY0gpgpVLdAcVj5JgucmUk9xkyk2mJETiP_yX9_x1PID5V_LXXgm8PQWgTPndQZRJO_AajCuWsjTB_Z__7kG5np13Ws1f4QhpCmv0xZ8kMlGJ5X5b57ZNQjHmvAB-A-u-nCY</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Menzel-Severing, Johannes, MD, MSc</creator><creator>Kruse, Friedrich E., MD</creator><creator>Schlötzer-Schrehardt, Ursula, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Stem cell–based therapy for corneal epithelial reconstruction: present and future</title><author>Menzel-Severing, Johannes, MD, MSc ; Kruse, Friedrich E., MD ; Schlötzer-Schrehardt, Ursula, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-52abdeaf30083de2dc96a95bf9241576ff6c3cf2eeac2b982a84295d951858093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cell- and Tissue-Based Therapy</topic><topic>Cells, Cultured</topic><topic>Corneal Diseases - therapy</topic><topic>Epithelium, Corneal - pathology</topic><topic>Epithelium, Corneal - transplantation</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Limbus Corneae - cytology</topic><topic>Ophthalmology</topic><topic>Reconstructive Surgical Procedures</topic><topic>Stem Cell Transplantation</topic><topic>Tissue Engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menzel-Severing, Johannes, MD, MSc</creatorcontrib><creatorcontrib>Kruse, Friedrich E., MD</creatorcontrib><creatorcontrib>Schlötzer-Schrehardt, Ursula, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menzel-Severing, Johannes, MD, MSc</au><au>Kruse, Friedrich E., MD</au><au>Schlötzer-Schrehardt, Ursula, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stem cell–based therapy for corneal epithelial reconstruction: present and future</atitle><jtitle>Canadian journal of ophthalmology</jtitle><addtitle>Can J Ophthalmol</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>48</volume><issue>1</issue><spage>13</spage><epage>21</epage><pages>13-21</pages><issn>0008-4182</issn><eissn>1715-3360</eissn><abstract>Abstract Limbal stem cell deficiency is a painful and potentially blinding disease. Cultured limbal epithelial transplantation (CLET) is frequently performed for corneal surface reconstruction with variable clinical success. This work summarizes recent developments and trends that have the potential to increase safety and efficacy of CLET in the future. Apart from gradual transition to xenobiotic-free culture systems, novel biofunctional scaffolds presenting components of stem cell microenvironments aim at promoting long-term maintenance of stem cells in vitro and after transplantation. Hair follicles and other tissues may serve as autologous sources of adult stem cells in bilateral ocular surface disease. However, despite all progress made in the fields of tissue engineering and cell therapy, it is unlikely that CLET will yield fully satisfactory clinical results until the factors that govern limbal stem cell maintenance and differentiation are identified.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>23419294</pmid><doi>10.1016/j.jcjo.2012.11.009</doi><tpages>9</tpages></addata></record> |
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| ispartof | Canadian journal of ophthalmology, 2013-02, Vol.48 (1), p.13-21 |
| issn | 0008-4182 1715-3360 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cell- and Tissue-Based Therapy Cells, Cultured Corneal Diseases - therapy Epithelium, Corneal - pathology Epithelium, Corneal - transplantation Humans Internal Medicine Limbus Corneae - cytology Ophthalmology Reconstructive Surgical Procedures Stem Cell Transplantation Tissue Engineering |
| title | Stem cell–based therapy for corneal epithelial reconstruction: present and future |
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