Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura
Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (I...
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| Veröffentlicht in: | Archives of Dermatological Research 2013-03, Vol.305 (2), p.173-177 |
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| creator | Chen, Tao Jia, Rui-zhen Guo, Zai-pei Cao, Na Li, Meng-meng Jiao, Xiao-yan |
| description | Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP. |
| doi_str_mv | 10.1007/s00403-012-1268-7 |
| format | Article |
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However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-012-1268-7</identifier><identifier>PMID: 22836779</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Antibodies, Anticardiolipin - biosynthesis ; Antibodies, Anticardiolipin - blood ; Autoantibodies - biosynthesis ; Autoantibodies - blood ; Child ; Dermatology ; Disease Progression ; Female ; Humans ; Immunoglobulin A - biosynthesis ; Immunoglobulin A - blood ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; Interleukins - blood ; Male ; Medicine ; Medicine & Public Health ; Purpura, Schoenlein-Henoch - blood ; Purpura, Schoenlein-Henoch - diagnosis ; Purpura, Schoenlein-Henoch - immunology ; Receptors, Cell Surface - blood ; Short Communication ; Young Adult</subject><ispartof>Archives of Dermatological Research, 2013-03, Vol.305 (2), p.173-177</ispartof><rights>Springer-Verlag 2012</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-54a5d8de332744559f88cf2222e5b3311321110fd2be417d52a207aff2650be93</citedby><cites>FETCH-LOGICAL-c372t-54a5d8de332744559f88cf2222e5b3311321110fd2be417d52a207aff2650be93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-012-1268-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-012-1268-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22836779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Jia, Rui-zhen</creatorcontrib><creatorcontrib>Guo, Zai-pei</creatorcontrib><creatorcontrib>Cao, Na</creatorcontrib><creatorcontrib>Li, Meng-meng</creatorcontrib><creatorcontrib>Jiao, Xiao-yan</creatorcontrib><title>Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Anticardiolipin - biosynthesis</subject><subject>Antibodies, Anticardiolipin - blood</subject><subject>Autoantibodies - biosynthesis</subject><subject>Autoantibodies - blood</subject><subject>Child</subject><subject>Dermatology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin A - blood</subject><subject>Interleukin-1 Receptor-Like 1 Protein</subject><subject>Interleukin-33</subject><subject>Interleukins - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Purpura, Schoenlein-Henoch - blood</subject><subject>Purpura, Schoenlein-Henoch - diagnosis</subject><subject>Purpura, Schoenlein-Henoch - immunology</subject><subject>Receptors, Cell Surface - blood</subject><subject>Short Communication</subject><subject>Young Adult</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kM9Kw0AQxhdRbKl9AC8S8OJldfZPsslRilqh0IMK3pZNMrGpaVJ3E8UX8wV8MTekiggOAwP7_ebb4SPkmME5A1AXDkCCoMA4ZTyKqdojYyYFpxAlj_tkDEICFVESjcjUuTX4UiA5qEMy4jwWkVLJmCyvKnw1LeaBQ9ttgrJu0VbYPZc1FSLwIlbOvwZb05ZYty54K9tVMMe6yVb0Llt9ftQV9npnfZsjclCYyuF0Nyfk4frqfjani-XN7exyQTOheEtDacI8zlEIrqQMw6SI46zgvjBMhWBMcMYYFDlPUTKVh9z4y01R8CiEFBMxIWeD79Y2Lx26Vm9Kl2FVmRqbzmnG40Qq7848evoHXTedrf11PRVHLFQKPMUGKrONcxYLvbXlxth3zUD3geshcO0D133gWvmdk51zl24w_9n4jtcDfACcl-ontL--_tf1C1Piick</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Chen, Tao</creator><creator>Jia, Rui-zhen</creator><creator>Guo, Zai-pei</creator><creator>Cao, Na</creator><creator>Li, Meng-meng</creator><creator>Jiao, Xiao-yan</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura</title><author>Chen, Tao ; Jia, Rui-zhen ; Guo, Zai-pei ; Cao, Na ; Li, Meng-meng ; Jiao, Xiao-yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-54a5d8de332744559f88cf2222e5b3311321110fd2be417d52a207aff2650be93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Anticardiolipin - biosynthesis</topic><topic>Antibodies, Anticardiolipin - blood</topic><topic>Autoantibodies - biosynthesis</topic><topic>Autoantibodies - blood</topic><topic>Child</topic><topic>Dermatology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin A - blood</topic><topic>Interleukin-1 Receptor-Like 1 Protein</topic><topic>Interleukin-33</topic><topic>Interleukins - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Purpura, Schoenlein-Henoch - blood</topic><topic>Purpura, Schoenlein-Henoch - diagnosis</topic><topic>Purpura, Schoenlein-Henoch - immunology</topic><topic>Receptors, Cell Surface - blood</topic><topic>Short Communication</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Tao</creatorcontrib><creatorcontrib>Jia, Rui-zhen</creatorcontrib><creatorcontrib>Guo, Zai-pei</creatorcontrib><creatorcontrib>Cao, Na</creatorcontrib><creatorcontrib>Li, Meng-meng</creatorcontrib><creatorcontrib>Jiao, Xiao-yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Tao</au><au>Jia, Rui-zhen</au><au>Guo, Zai-pei</au><au>Cao, Na</au><au>Li, Meng-meng</au><au>Jiao, Xiao-yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>305</volume><issue>2</issue><spage>173</spage><epage>177</epage><pages>173-177</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis and is known as an immunoglobulin (Ig) A related immune complex-mediated disease. However, the molecular mechanisms in the development of HSP are not yet fully understood. Herein, we investigated the serum levels of Interleukin (IL)-33 and soluble ST2 (sST2) in HSP patients and their association with disease severity and IgA autoantibodies production. The serum levels of IL-33 and sST2 were measured by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) in the serum of 33 patients with HSP and 22 controls. Serum levels of IgA anti-endothelial cell antibodies (AECA) and IgA anticardiolipin antibodies (ACA) in HSP patients were detected by double antigen sandwich ELISA. Our results indicated that serum levels of IL-33 but not sST2 were significantly elevated in patients with HSP in acute stage and restored to normal levels in convalescent stage. Moreover, serum IL-33 levels were correlated with the severity of HSP and serum concentrations of AECA-IgA and ACA-IgA. Taken together, we show firstly that serum IL-33 is abnormally elevated in HSP patients. IL-33 might be associated with the IgA autoantibodies production in the pathogenesis of HSP.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22836779</pmid><doi>10.1007/s00403-012-1268-7</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Antibodies, Anticardiolipin - biosynthesis Antibodies, Anticardiolipin - blood Autoantibodies - biosynthesis Autoantibodies - blood Child Dermatology Disease Progression Female Humans Immunoglobulin A - biosynthesis Immunoglobulin A - blood Interleukin-1 Receptor-Like 1 Protein Interleukin-33 Interleukins - blood Male Medicine Medicine & Public Health Purpura, Schoenlein-Henoch - blood Purpura, Schoenlein-Henoch - diagnosis Purpura, Schoenlein-Henoch - immunology Receptors, Cell Surface - blood Short Communication Young Adult |
| title | Elevated serum interleukin-33 levels in patients with Henoch-Schönlein purpura |
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