Cadherin junctions and their cytoskeleton(s)
Classical cadherin adhesion receptors exert many of their biological effects through close cooperation with the cytoskeleton. Much attention has focused on attempting to understand the physical interactions between cadherin molecular complexes and cortical actin filaments. In this review we aim to d...
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| Veröffentlicht in: | Current opinion in cell biology 2013-02, Vol.25 (1), p.39-46 |
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| creator | Brieher, William M Yap, Alpha S |
| description | Classical cadherin adhesion receptors exert many of their biological effects through close cooperation with the cytoskeleton. Much attention has focused on attempting to understand the physical interactions between cadherin molecular complexes and cortical actin filaments. In this review we aim to draw attention to other issues that highlight the diverse and dynamic cytoskeletons that contribute to cadherin function. First, we discuss the regulation of actin filament dynamics in the cadherin-based junctional cytoskeleton, focusing on the emerging role of Arp2/3 as a junctional actin nucleator and its implications for actin homeostasis at junctions. Second, we review recent developments in understanding the impact of microtubules on cadherin function. Together, these emphasize that cadherins cooperate with multiple dynamic cytoskeletal networks at cell–cell junctions. |
| doi_str_mv | 10.1016/j.ceb.2012.10.010 |
| format | Article |
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| ispartof | Current opinion in cell biology, 2013-02, Vol.25 (1), p.39-46 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Actin Cytoskeleton - metabolism Actins - metabolism Cadherins - metabolism Cytoskeleton - metabolism Homeostasis Intercellular Junctions - metabolism Internal Medicine Microtubules - metabolism Myosins - metabolism |
| title | Cadherin junctions and their cytoskeleton(s) |
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