Mutant KRAS Codon 12 and 13 Alleles in Patients With Metastatic Colorectal Cancer: Assessment As Prognostic and Predictive Biomarkers of Response to Panitumumab

Panitumumab, a fully human monoclonal antibody targeting the epidermal growth factor receptor (EGFR), has demonstrated significant improvements in progression-free survival (PFS) in patients with wild-type KRAS metastatic colorectal cancer (mCRC) in studies 20050203 (first line), 20050181 (second li...

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Veröffentlicht in:	Journal of clinical oncology 2013-02, Vol.31 (6), p.759-765
Hauptverfasser:	PEETERS, Marc, DOUILLARD, Jean-Yves, VAN CUTSEM, Eric, SIENA, Salvatore, ZHANG, Kathy, WILLIAMS, Richard, WIEZOREK, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers, Tumor - genetics Camptothecin - administration & dosage Camptothecin - analogs & derivatives Codon - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Drug Resistance, Neoplasm - genetics Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Humans Leucovorin - administration & dosage Medical sciences Mutation Neoplasm Metastasis Organoplatinum Compounds - administration & dosage Outcome Assessment (Health Care) Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) Randomized Controlled Trials as Topic ras Proteins - genetics Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors
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