Laryngeal tumor volume as a predictor for thyroid cartilage penetration
Background Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage...
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| Veröffentlicht in: | Head & neck 2013-03, Vol.35 (3), p.426-430 |
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| creator | Kats, Svetlana S. Muller, Susan Aiken, Ashley Hudgins, Patricia A. Wadsworth, J. Trad Shin, Dong M. Khuri, Fadlo Beitler, Jonathan J. |
| description | Background
Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx.
Methods
Ninety‐four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment‐planning software.
Results
Among the 49 nonirradiated patients, the mean GTVs of patients with (n = 15) and without (n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 (p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25–50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively (p = .003).
Conclusions
Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013 |
| doi_str_mv | 10.1002/hed.22995 |
| format | Article |
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Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx.
Methods
Ninety‐four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment‐planning software.
Results
Among the 49 nonirradiated patients, the mean GTVs of patients with (n = 15) and without (n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 (p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25–50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively (p = .003).
Conclusions
Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.22995</identifier><identifier>PMID: 22488941</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Cervical cancer ; glottic cancer ; Humans ; Laryngeal Neoplasms - diagnostic imaging ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - surgery ; laryngectomy ; Larynx ; Larynx - diagnostic imaging ; Larynx - pathology ; larynx cancer ; Middle Aged ; Neoplasm Invasiveness ; Retrospective Studies ; thyroid cartilage ; Thyroid Cartilage - diagnostic imaging ; Thyroid Cartilage - pathology ; Tomography, X-Ray Computed ; Tumor Burden ; tumor volume</subject><ispartof>Head & neck, 2013-03, Vol.35 (3), p.426-430</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-4f90bffc18b2c6bd512a13b31860dffe99da299059a567d794d299aca6b3a16d3</citedby><cites>FETCH-LOGICAL-c3915-4f90bffc18b2c6bd512a13b31860dffe99da299059a567d794d299aca6b3a16d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.22995$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.22995$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22488941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kats, Svetlana S.</creatorcontrib><creatorcontrib>Muller, Susan</creatorcontrib><creatorcontrib>Aiken, Ashley</creatorcontrib><creatorcontrib>Hudgins, Patricia A.</creatorcontrib><creatorcontrib>Wadsworth, J. Trad</creatorcontrib><creatorcontrib>Shin, Dong M.</creatorcontrib><creatorcontrib>Khuri, Fadlo</creatorcontrib><creatorcontrib>Beitler, Jonathan J.</creatorcontrib><title>Laryngeal tumor volume as a predictor for thyroid cartilage penetration</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx.
Methods
Ninety‐four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment‐planning software.
Results
Among the 49 nonirradiated patients, the mean GTVs of patients with (n = 15) and without (n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 (p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25–50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively (p = .003).
Conclusions
Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Cervical cancer</subject><subject>glottic cancer</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - diagnostic imaging</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>laryngectomy</subject><subject>Larynx</subject><subject>Larynx - diagnostic imaging</subject><subject>Larynx - pathology</subject><subject>larynx cancer</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Retrospective Studies</subject><subject>thyroid cartilage</subject><subject>Thyroid Cartilage - diagnostic imaging</subject><subject>Thyroid Cartilage - pathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><subject>tumor volume</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlOwzAQhi0EolA48AIoEhc4pPWWxUfUFSkCibJIXCwndtqUbNgJ0LfH3TggcbBsj775NfMBcIFgD0GI-wslexgz5h2AEwRZ4EJCg8P1mxKXwIB2wKkxSwgh8Sk-Bh2MaRgyik7AJBJ6Vc6VyJ2mLSrtfFZ5WyhHGEc4tVYySxpbTe1pFitdZdJJhG6yXMyVU6tSNVo0WVWegaNU5Ead7-4ueB6PngZTN3qY3A1uIzchDHkuTRmM0zRBYYwTP5YewgKRmKDQhzJNFWNS2EWgx4TnBzJgVNqvSIQfE4F8Sbrgeptb6-qjVabhRWYSleeiVFVrOMJ2MYYRoRa9-oMuq1aXdroNBSnyvcBSN1sq0ZUxWqW81llhpXAE-dout3b5xq5lL3eJbVzY6p7c67RAfwt8Zbla_Z_Ep6PhPtLddmSmUd-_HUK_cz8ggcdf7yd8NnybjcOXRx6RH_YnkmI</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Kats, Svetlana S.</creator><creator>Muller, Susan</creator><creator>Aiken, Ashley</creator><creator>Hudgins, Patricia A.</creator><creator>Wadsworth, J. Trad</creator><creator>Shin, Dong M.</creator><creator>Khuri, Fadlo</creator><creator>Beitler, Jonathan J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Laryngeal tumor volume as a predictor for thyroid cartilage penetration</title><author>Kats, Svetlana S. ; Muller, Susan ; Aiken, Ashley ; Hudgins, Patricia A. ; Wadsworth, J. Trad ; Shin, Dong M. ; Khuri, Fadlo ; Beitler, Jonathan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-4f90bffc18b2c6bd512a13b31860dffe99da299059a567d794d299aca6b3a16d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Cervical cancer</topic><topic>glottic cancer</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - diagnostic imaging</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>laryngectomy</topic><topic>Larynx</topic><topic>Larynx - diagnostic imaging</topic><topic>Larynx - pathology</topic><topic>larynx cancer</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Retrospective Studies</topic><topic>thyroid cartilage</topic><topic>Thyroid Cartilage - diagnostic imaging</topic><topic>Thyroid Cartilage - pathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><topic>tumor volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kats, Svetlana S.</creatorcontrib><creatorcontrib>Muller, Susan</creatorcontrib><creatorcontrib>Aiken, Ashley</creatorcontrib><creatorcontrib>Hudgins, Patricia A.</creatorcontrib><creatorcontrib>Wadsworth, J. Trad</creatorcontrib><creatorcontrib>Shin, Dong M.</creatorcontrib><creatorcontrib>Khuri, Fadlo</creatorcontrib><creatorcontrib>Beitler, Jonathan J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kats, Svetlana S.</au><au>Muller, Susan</au><au>Aiken, Ashley</au><au>Hudgins, Patricia A.</au><au>Wadsworth, J. Trad</au><au>Shin, Dong M.</au><au>Khuri, Fadlo</au><au>Beitler, Jonathan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Laryngeal tumor volume as a predictor for thyroid cartilage penetration</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2013-03</date><risdate>2013</risdate><volume>35</volume><issue>3</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Review of laryngectomy specimens demonstrated that preoperative CT scanning is suboptimal in predicting both thyroid cartilage penetration and extralaryngeal spread. We investigated the association between the CT‐based gross tumor volume (GTV) with pathologic evidence of thyroid cartilage penetration among patients undergoing laryngectomy for squamous cell carcinoma (SCC) of the larynx.
Methods
Ninety‐four patients were identified who underwent total laryngectomy for SCC of the larynx. GTV, as defined by preoperative diagnostic CT scan, was contoured and analyzed using treatment‐planning software.
Results
Among the 49 nonirradiated patients, the mean GTVs of patients with (n = 15) and without (n = 34) thyroid cartilage penetration was 60.1 and 28.0 cm3 (p = .004). When the nonirradiated patients were divided into 3 GTV groups (≤25 cm3, 25–50 cm3, >50 cm3), the rates of thyroid cartilage penetration were 23%, 17%, and 78%, respectively (p = .003).
Conclusions
Laryngeal tumor volume is associated with pathologic evidence of thyroid cartilage penetration in nonirradiated patients. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22488941</pmid><doi>10.1002/hed.22995</doi><tpages>5</tpages></addata></record> |
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| ispartof | Head & neck, 2013-03, Vol.35 (3), p.426-430 |
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| subjects | Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Cervical cancer glottic cancer Humans Laryngeal Neoplasms - diagnostic imaging Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery laryngectomy Larynx Larynx - diagnostic imaging Larynx - pathology larynx cancer Middle Aged Neoplasm Invasiveness Retrospective Studies thyroid cartilage Thyroid Cartilage - diagnostic imaging Thyroid Cartilage - pathology Tomography, X-Ray Computed Tumor Burden tumor volume |
| title | Laryngeal tumor volume as a predictor for thyroid cartilage penetration |
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