Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar

Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin (2) and...

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Veröffentlicht in:	Chemistry & biodiversity 2013-02, Vol.10 (2), p.233-240
Hauptverfasser:	Dai, Yumin, Harinantenaina, Liva, Brodie, Peggy J., Birkinshaw, Chris, Randrianaivo, Richard, Applequist, Wendy, Ratsimbason, Michel, Rasamison, Vincent E., Shen, Yongchun, TenDyke, Karen, Kingston, David G. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antiproliferative activity Cell Line, Tumor Cell Proliferation - drug effects Female Humans Lung Neoplasms - drug therapy Madagascar Melanoma - drug therapy Nematostylis anthophylla Ovarian cancer Ovarian Neoplasms - drug therapy Rubiaceae - chemistry Saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Triterpene saponins Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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