Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar
Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin (2) and...
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| Veröffentlicht in: | Chemistry & biodiversity 2013-02, Vol.10 (2), p.233-240 |
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| creator | Dai, Yumin Harinantenaina, Liva Brodie, Peggy J. Birkinshaw, Chris Randrianaivo, Richard Applequist, Wendy Ratsimbason, Michel Rasamison, Vincent E. Shen, Yongchun TenDyke, Karen Kingston, David G. I. |
| description | Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin (2) and 6″‐O‐acetylrandianin (3). The structures of the two new compounds were elucidated based on analysis of their 1D‐ and 2D‐NMR spectra, and mass spectrometric data. The three isolated triterpene saponins displayed moderate but selective antiproliferative activities, with IC50 values of 1.2, 1.7, and 2.2 μM, respectively, against the A2780 ovarian cancer, but only weak inhibitions of the proliferation of A2058 melanoma and the H522 lung cancer cell lines. |
| doi_str_mv | 10.1002/cbdv.201200156 |
| format | Article |
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The three isolated triterpene saponins displayed moderate but selective antiproliferative activities, with IC50 values of 1.2, 1.7, and 2.2 μM, respectively, against the A2780 ovarian cancer, but only weak inhibitions of the proliferation of A2058 melanoma and the H522 lung cancer cell lines.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.201200156</identifier><identifier>PMID: 23418170</identifier><language>eng</language><publisher>Zürich: WILEY-VCH Verlag</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Antiproliferative activity ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Female ; Humans ; Lung Neoplasms - drug therapy ; Madagascar ; Melanoma - drug therapy ; Nematostylis anthophylla ; Ovarian cancer ; Ovarian Neoplasms - drug therapy ; Rubiaceae - chemistry ; Saponins ; Saponins - chemistry ; Saponins - isolation & purification ; Saponins - pharmacology ; Triterpene saponins ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology</subject><ispartof>Chemistry & biodiversity, 2013-02, Vol.10 (2), p.233-240</ispartof><rights>Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich</rights><rights>Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5176-561a3ca8e51196590d06b4803a41ead51604cfe56a4662b162be54de33352aac3</citedby><cites>FETCH-LOGICAL-c5176-561a3ca8e51196590d06b4803a41ead51604cfe56a4662b162be54de33352aac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.201200156$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.201200156$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23418170$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Yumin</creatorcontrib><creatorcontrib>Harinantenaina, Liva</creatorcontrib><creatorcontrib>Brodie, Peggy J.</creatorcontrib><creatorcontrib>Birkinshaw, Chris</creatorcontrib><creatorcontrib>Randrianaivo, Richard</creatorcontrib><creatorcontrib>Applequist, Wendy</creatorcontrib><creatorcontrib>Ratsimbason, Michel</creatorcontrib><creatorcontrib>Rasamison, Vincent E.</creatorcontrib><creatorcontrib>Shen, Yongchun</creatorcontrib><creatorcontrib>TenDyke, Karen</creatorcontrib><creatorcontrib>Kingston, David G. I.</creatorcontrib><title>Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar</title><title>Chemistry & biodiversity</title><addtitle>Chemistry & Biodiversity</addtitle><description>Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin (2) and 6″‐O‐acetylrandianin (3). The structures of the two new compounds were elucidated based on analysis of their 1D‐ and 2D‐NMR spectra, and mass spectrometric data. 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I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chemistry & Biodiversity</addtitle><date>2013-02</date><risdate>2013</risdate><volume>10</volume><issue>2</issue><spage>233</spage><epage>240</epage><pages>233-240</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>Investigation of the endemic Madagascan plant Nematostylis anthophylla (Rubiaceae) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the known triterpene saponin randianin (1), and the two new bioactive triterpene saponins 2″‐O‐acetylrandianin (2) and 6″‐O‐acetylrandianin (3). The structures of the two new compounds were elucidated based on analysis of their 1D‐ and 2D‐NMR spectra, and mass spectrometric data. The three isolated triterpene saponins displayed moderate but selective antiproliferative activities, with IC50 values of 1.2, 1.7, and 2.2 μM, respectively, against the A2780 ovarian cancer, but only weak inhibitions of the proliferation of A2058 melanoma and the H522 lung cancer cell lines.</abstract><cop>Zürich</cop><pub>WILEY-VCH Verlag</pub><pmid>23418170</pmid><doi>10.1002/cbdv.201200156</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antiproliferative activity Cell Line, Tumor Cell Proliferation - drug effects Female Humans Lung Neoplasms - drug therapy Madagascar Melanoma - drug therapy Nematostylis anthophylla Ovarian cancer Ovarian Neoplasms - drug therapy Rubiaceae - chemistry Saponins Saponins - chemistry Saponins - isolation & purification Saponins - pharmacology Triterpene saponins Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology |
| title | Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar |
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