Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation
The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds h...
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| Veröffentlicht in: | Biotechnology advances 2013-03, Vol.31 (2), p.287-311 |
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| container_title | Biotechnology advances |
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| creator | Ozcengiz, Gulay Demain, Arnold L. |
| description | The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $20billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems. Strain improvement of the penicillin-producing species of Penicillium has been truly remarkable, with present strains producing about 100,000times more penicillin that the original Penicillium notatum of Alexander Fleming. A tremendous amount of information has been gathered on the biosynthetic enzymes involved, the pathways of biosynthesis of beta-lactams as well as their regulation, and the genomics and proteomics of the producing organisms. Modern aspects of the processes are discussed in the present review including genetics, molecular biology, metabolic engineering, genomics and proteomics. |
| doi_str_mv | 10.1016/j.biotechadv.2012.12.001 |
| format | Article |
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Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $20billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems. Strain improvement of the penicillin-producing species of Penicillium has been truly remarkable, with present strains producing about 100,000times more penicillin that the original Penicillium notatum of Alexander Fleming. A tremendous amount of information has been gathered on the biosynthetic enzymes involved, the pathways of biosynthesis of beta-lactams as well as their regulation, and the genomics and proteomics of the producing organisms. 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Psychology ; Gene Expression Regulation ; Genetic Engineering - methods ; Genome, Bacterial ; Hydrogen-Ion Concentration ; Lysine - metabolism ; Metabolic Engineering - methods ; Methionine - metabolism ; Nitrogen - metabolism ; Oxygen - metabolism ; Penicillins ; Penicillins - biosynthesis ; Phosphorus - metabolism ; Regulation</subject><ispartof>Biotechnology advances, 2013-03, Vol.31 (2), p.287-311</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. 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Despite this old age, they continue to provide health to the world population by virtue of industrial production and discoveries of new secondary metabolite molecules with useful activities. Sales of these remarkable compounds have reached over $20billion dollars per year. They include penicillins, cephalosporins, cefoxitin, monobactams, clavulanic acid and carbapenems. Strain improvement of the penicillin-producing species of Penicillium has been truly remarkable, with present strains producing about 100,000times more penicillin that the original Penicillium notatum of Alexander Fleming. A tremendous amount of information has been gathered on the biosynthetic enzymes involved, the pathways of biosynthesis of beta-lactams as well as their regulation, and the genomics and proteomics of the producing organisms. Modern aspects of the processes are discussed in the present review including genetics, molecular biology, metabolic engineering, genomics and proteomics.</description><subject>Antibiotics</subject><subject>Beta-lactams</subject><subject>Biological and medical sciences</subject><subject>Biosynthesis</subject><subject>Biotechnology</subject><subject>Biotechnology - methods</subject><subject>Cephalosporins</subject><subject>Cephalosporins - biosynthesis</subject><subject>Clavams</subject><subject>Clavulanic Acids - biosynthesis</subject><subject>Enzymes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genetic Engineering - methods</subject><subject>Genome, Bacterial</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lysine - metabolism</subject><subject>Metabolic Engineering - methods</subject><subject>Methionine - metabolism</subject><subject>Nitrogen - metabolism</subject><subject>Oxygen - metabolism</subject><subject>Penicillins</subject><subject>Penicillins - biosynthesis</subject><subject>Phosphorus - metabolism</subject><subject>Regulation</subject><issn>0734-9750</issn><issn>1873-1899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1rFDEUhoModlv9C5IbwYvONsl8JLnU0lqhUBC9DmcyZ9ws2cyYM7vQf2-WXe2lEMg54TlvwhPGuBRrKWR3s133YVrQb2A4rJWQal2WEPIVW0mj60oaa1-zldB1U1ndigt2SbQtQCva-i27ULVSxhqxYvAdPaaFlyBIHomHxJcN8pJPz6lUFIhPI58xBR9iDImuucd5A3Giecql55AG7iMcYHeqw0I84699hCVM6R17M0IkfH_er9jP-7sftw_V49PXb7efHyvfaLFU1ssRjOrbTmjbyLFVCP3YW9OV06ZXLWorOxjQgtetqmXTY-OPHXTWjqK-Yp9OuXOefu-RFrcL5DFGSDjtyUllihXZ6SNqTqjPE1HG0c057CA_OyncUbDbuhfB7ii4jLvir4x-ON-y73c4_Bv8a7QAH88AkIc45qI10AunhZGyrQv35cRhcXIImB35gOULhpDRL26Ywv9f8weQ7Z_3</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Ozcengiz, Gulay</creator><creator>Demain, Arnold L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation</title><author>Ozcengiz, Gulay ; Demain, Arnold L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-9c1fa82b5607941f52eabfb986a824b25e7916ade9ac752314be4ce9aca699f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antibiotics</topic><topic>Beta-lactams</topic><topic>Biological and medical sciences</topic><topic>Biosynthesis</topic><topic>Biotechnology</topic><topic>Biotechnology - methods</topic><topic>Cephalosporins</topic><topic>Cephalosporins - biosynthesis</topic><topic>Clavams</topic><topic>Clavulanic Acids - biosynthesis</topic><topic>Enzymes - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Genetic Engineering - methods</topic><topic>Genome, Bacterial</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lysine - metabolism</topic><topic>Metabolic Engineering - methods</topic><topic>Methionine - metabolism</topic><topic>Nitrogen - metabolism</topic><topic>Oxygen - metabolism</topic><topic>Penicillins</topic><topic>Penicillins - biosynthesis</topic><topic>Phosphorus - metabolism</topic><topic>Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozcengiz, Gulay</creatorcontrib><creatorcontrib>Demain, Arnold L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biotechnology advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozcengiz, Gulay</au><au>Demain, Arnold L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation</atitle><jtitle>Biotechnology advances</jtitle><addtitle>Biotechnol Adv</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>31</volume><issue>2</issue><spage>287</spage><epage>311</epage><pages>287-311</pages><issn>0734-9750</issn><eissn>1873-1899</eissn><coden>BIADDD</coden><abstract>The beta-lactam antibiotics have been serving mankind for over 70years. 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| fulltext | fulltext |
| identifier | ISSN: 0734-9750 |
| ispartof | Biotechnology advances, 2013-03, Vol.31 (2), p.287-311 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibiotics Beta-lactams Biological and medical sciences Biosynthesis Biotechnology Biotechnology - methods Cephalosporins Cephalosporins - biosynthesis Clavams Clavulanic Acids - biosynthesis Enzymes - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genetic Engineering - methods Genome, Bacterial Hydrogen-Ion Concentration Lysine - metabolism Metabolic Engineering - methods Methionine - metabolism Nitrogen - metabolism Oxygen - metabolism Penicillins Penicillins - biosynthesis Phosphorus - metabolism Regulation |
| title | Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation |
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