Partial loss of contractile marker proteins in human testicular peritubular cells in infertility patients

Summary Fibrotic remodelling of the testicular tubular wall is common in human male infertility caused by impaired spermatogenesis. We hypothesized that this morphological change bears witness of an underlying fundamentally altered state of the cells building this wall, that is, peritubular smooth m...

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Veröffentlicht in:	Andrology (Oxford) 2013-03, Vol.1 (2), p.318-324
Hauptverfasser:	Welter, H., Kampfer, C., Lauf, S., Feil, R., Schwarzer, J. U., Köhn, F.‐M., Mayerhofer, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers Biopsy Birth control Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calponins Contractile Proteins - genetics Contractile Proteins - metabolism contractility Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism differentiation Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans immune cells Infertility, Male - genetics Infertility, Male - metabolism Kinases Male Male genital diseases male infertility Mammalian male genital system Medical sciences Microfilament Proteins - genetics Microfilament Proteins - metabolism Muscle, Smooth, Vascular Myosin Heavy Chains - genetics Myosin Heavy Chains - metabolism Prostaglandin D2 - analogs & derivatives prostaglandins RNA, Messenger - genetics RNA, Messenger - metabolism Seminiferous Tubules - metabolism Seminiferous Tubules - pathology Smooth muscle smooth muscle cells Sperm Motility Spermatogenesis Spermatogenesis - genetics Sterility. Assisted procreation testis Testis - metabolism Testis - pathology Vertebrates: reproduction
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