The role of autonomic nervous system function in hypothermia-mediated sepsis protection
Abstract Objective The objective of this study is to determine whether hypothermia will lessen decreases in heart rate variability and improve outcome in a rat model of sepsis. Methods Thirty-six male Sprague-Dawley rats were randomized into 3 groups: control, low sepsis, and high sepsis groups. The...
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| Veröffentlicht in: | The American journal of emergency medicine 2013-02, Vol.31 (2), p.375-380 |
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| creator | Chang, Yun-Te, MD, MPH Wann, Shue-Ren, MD Tsai, Jung-Shun, PhD Kao, Chih-Hsiang, MD Lee, Po-Tsang, MD, PhD Huang, Neng-Chyan, MD Yen, Cheng-Chang, MD Huang, Mu-Shun, MD Chang, Hong-Tai, MD |
| description | Abstract Objective The objective of this study is to determine whether hypothermia will lessen decreases in heart rate variability and improve outcome in a rat model of sepsis. Methods Thirty-six male Sprague-Dawley rats were randomized into 3 groups: control, low sepsis, and high sepsis groups. These groups were each subdivided into a normothermia (37°C) (n = 6) and a hypothermia group (34°C) (n = 6). Cyclophosphamide (100 mg/kg) was administered 5 days before Staphylococcus aureus injection to produce conditions in which sepsis could be induced reliably. Hypothermic rats received temperature reduction for 1 hour post injection. Electrocardiogram was recorded before, after, and 1 day after staphylococcal injection, and the low frequency, high frequency (HF), and LF/HF ratio measurements of heart rate variability and the frequencies of arrhythmia were recorded. The effects of time, sepsis severity, and hypothermia on these variables were analyzed using a multivariate generalized estimation equation mode. Results Four deaths occurred in the normothermic group, and none, in the hypothermic group. Sepsis of both low and high severity increased low frequency and HF 1 day after sepsis induction. Hypothermia significantly decreased HF in low, but not high sepsis severity. Conclusions Hypothermia decreased mortality in septic rats. The influence of hypothermia on HF depended on the severity of the sepsis. |
| doi_str_mv | 10.1016/j.ajem.2012.08.028 |
| format | Article |
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Methods Thirty-six male Sprague-Dawley rats were randomized into 3 groups: control, low sepsis, and high sepsis groups. These groups were each subdivided into a normothermia (37°C) (n = 6) and a hypothermia group (34°C) (n = 6). Cyclophosphamide (100 mg/kg) was administered 5 days before Staphylococcus aureus injection to produce conditions in which sepsis could be induced reliably. Hypothermic rats received temperature reduction for 1 hour post injection. Electrocardiogram was recorded before, after, and 1 day after staphylococcal injection, and the low frequency, high frequency (HF), and LF/HF ratio measurements of heart rate variability and the frequencies of arrhythmia were recorded. The effects of time, sepsis severity, and hypothermia on these variables were analyzed using a multivariate generalized estimation equation mode. Results Four deaths occurred in the normothermic group, and none, in the hypothermic group. Sepsis of both low and high severity increased low frequency and HF 1 day after sepsis induction. Hypothermia significantly decreased HF in low, but not high sepsis severity. Conclusions Hypothermia decreased mortality in septic rats. The influence of hypothermia on HF depended on the severity of the sepsis.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2012.08.028</identifier><identifier>PMID: 23158600</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Autonomic Nervous System - physiology ; Bacteria ; Bacterial infections ; Blood ; Disease Models, Animal ; Electrocardiography ; Emergency ; Emergency medical care ; Feasibility studies ; Heart rate ; Heart Rate - physiology ; Hypothermia ; Hypothermia, Induced ; Immunization ; Infections ; Injection ; Injections ; Logistic Models ; Male ; Mortality ; Multivariate Analysis ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rodents ; Sepsis ; Sepsis - mortality ; Sepsis - physiopathology ; Sepsis - therapy ; Severity of Illness Index ; Staphylococcal Infections - mortality ; Staphylococcal Infections - physiopathology ; Staphylococcal Infections - therapy</subject><ispartof>The American journal of emergency medicine, 2013-02, Vol.31 (2), p.375-380</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-81c5fc7c2cebbd17c4f882be799fff3e6830e7bbd33ed59dbfaae48a9dbad6a63</citedby><cites>FETCH-LOGICAL-c439t-81c5fc7c2cebbd17c4f882be799fff3e6830e7bbd33ed59dbfaae48a9dbad6a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1287987216?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986,64374,64376,64378,72230</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23158600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Yun-Te, MD, MPH</creatorcontrib><creatorcontrib>Wann, Shue-Ren, MD</creatorcontrib><creatorcontrib>Tsai, Jung-Shun, PhD</creatorcontrib><creatorcontrib>Kao, Chih-Hsiang, MD</creatorcontrib><creatorcontrib>Lee, Po-Tsang, MD, PhD</creatorcontrib><creatorcontrib>Huang, Neng-Chyan, MD</creatorcontrib><creatorcontrib>Yen, Cheng-Chang, MD</creatorcontrib><creatorcontrib>Huang, Mu-Shun, MD</creatorcontrib><creatorcontrib>Chang, Hong-Tai, MD</creatorcontrib><title>The role of autonomic nervous system function in hypothermia-mediated sepsis protection</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Abstract Objective The objective of this study is to determine whether hypothermia will lessen decreases in heart rate variability and improve outcome in a rat model of sepsis. Methods Thirty-six male Sprague-Dawley rats were randomized into 3 groups: control, low sepsis, and high sepsis groups. These groups were each subdivided into a normothermia (37°C) (n = 6) and a hypothermia group (34°C) (n = 6). Cyclophosphamide (100 mg/kg) was administered 5 days before Staphylococcus aureus injection to produce conditions in which sepsis could be induced reliably. Hypothermic rats received temperature reduction for 1 hour post injection. Electrocardiogram was recorded before, after, and 1 day after staphylococcal injection, and the low frequency, high frequency (HF), and LF/HF ratio measurements of heart rate variability and the frequencies of arrhythmia were recorded. The effects of time, sepsis severity, and hypothermia on these variables were analyzed using a multivariate generalized estimation equation mode. Results Four deaths occurred in the normothermic group, and none, in the hypothermic group. Sepsis of both low and high severity increased low frequency and HF 1 day after sepsis induction. Hypothermia significantly decreased HF in low, but not high sepsis severity. Conclusions Hypothermia decreased mortality in septic rats. The influence of hypothermia on HF depended on the severity of the sepsis.</description><subject>Animals</subject><subject>Autonomic Nervous System - physiology</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>Blood</subject><subject>Disease Models, Animal</subject><subject>Electrocardiography</subject><subject>Emergency</subject><subject>Emergency medical care</subject><subject>Feasibility studies</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Hypothermia</subject><subject>Hypothermia, Induced</subject><subject>Immunization</subject><subject>Infections</subject><subject>Injection</subject><subject>Injections</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Mortality</subject><subject>Multivariate Analysis</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Sepsis</subject><subject>Sepsis - mortality</subject><subject>Sepsis - physiopathology</subject><subject>Sepsis - therapy</subject><subject>Severity of Illness Index</subject><subject>Staphylococcal Infections - mortality</subject><subject>Staphylococcal Infections - physiopathology</subject><subject>Staphylococcal Infections - therapy</subject><issn>0735-6757</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1r3DAQhkVpaLZJ_0APRdBLL3b0YVsylEIJbRMI5JCEHoUsj1i5trSR7MD--8jdtIEccpJAzzuaeQahj5SUlNDmbCj1AFPJCGUlkSVh8g3a0JqzQlJB36INEbwuGlGLY_Q-pYEQSqu6eoeOGae1bAjZoN-3W8AxjICDxXqZgw-TM9hDfAhLwmmfZpiwXbyZXfDYebzd78K8hTg5XUzQOz1DjxPskkt4F8MMf8lTdGT1mODD03mC7n7-uD2_KK6uf12ef78qTMXbOTdqamuEYQa6rqfCVFZK1oFoW2sth0ZyAiI_cQ593fad1RoqqfNN941u-An6cqibv75fIM1qcsnAOGoPeQBFmZSc0rZa0c8v0CEs0efuVkq0UjC6UuxAmRhSimDVLrpJx72iRK3a1aBW7WrVrohUWXsOfXoqvXTZyf_IP88Z-HoAILt4cBBVMg68yf5iFqb64F6v_-1F3IzOO6PHP7CH9DyHSjmjbtbFr3unjJCqEoQ_Aik4qrw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Chang, Yun-Te, MD, MPH</creator><creator>Wann, Shue-Ren, MD</creator><creator>Tsai, Jung-Shun, PhD</creator><creator>Kao, Chih-Hsiang, MD</creator><creator>Lee, Po-Tsang, MD, PhD</creator><creator>Huang, Neng-Chyan, MD</creator><creator>Yen, Cheng-Chang, MD</creator><creator>Huang, Mu-Shun, MD</creator><creator>Chang, Hong-Tai, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>The role of autonomic nervous system function in hypothermia-mediated sepsis protection</title><author>Chang, Yun-Te, MD, MPH ; Wann, Shue-Ren, MD ; Tsai, Jung-Shun, PhD ; Kao, Chih-Hsiang, MD ; Lee, Po-Tsang, MD, PhD ; Huang, Neng-Chyan, MD ; Yen, Cheng-Chang, MD ; Huang, Mu-Shun, MD ; Chang, Hong-Tai, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-81c5fc7c2cebbd17c4f882be799fff3e6830e7bbd33ed59dbfaae48a9dbad6a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - physiology</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>Blood</topic><topic>Disease Models, Animal</topic><topic>Electrocardiography</topic><topic>Emergency</topic><topic>Emergency medical care</topic><topic>Feasibility studies</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Hypothermia</topic><topic>Hypothermia, Induced</topic><topic>Immunization</topic><topic>Infections</topic><topic>Injection</topic><topic>Injections</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Mortality</topic><topic>Multivariate Analysis</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Sepsis</topic><topic>Sepsis - mortality</topic><topic>Sepsis - physiopathology</topic><topic>Sepsis - therapy</topic><topic>Severity of Illness Index</topic><topic>Staphylococcal Infections - mortality</topic><topic>Staphylococcal Infections - physiopathology</topic><topic>Staphylococcal Infections - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yun-Te, MD, MPH</creatorcontrib><creatorcontrib>Wann, Shue-Ren, MD</creatorcontrib><creatorcontrib>Tsai, Jung-Shun, PhD</creatorcontrib><creatorcontrib>Kao, Chih-Hsiang, MD</creatorcontrib><creatorcontrib>Lee, Po-Tsang, MD, PhD</creatorcontrib><creatorcontrib>Huang, Neng-Chyan, MD</creatorcontrib><creatorcontrib>Yen, Cheng-Chang, MD</creatorcontrib><creatorcontrib>Huang, Mu-Shun, MD</creatorcontrib><creatorcontrib>Chang, Hong-Tai, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of emergency medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yun-Te, MD, MPH</au><au>Wann, Shue-Ren, MD</au><au>Tsai, Jung-Shun, PhD</au><au>Kao, Chih-Hsiang, MD</au><au>Lee, Po-Tsang, MD, PhD</au><au>Huang, Neng-Chyan, MD</au><au>Yen, Cheng-Chang, MD</au><au>Huang, Mu-Shun, MD</au><au>Chang, Hong-Tai, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of autonomic nervous system function in hypothermia-mediated sepsis protection</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>31</volume><issue>2</issue><spage>375</spage><epage>380</epage><pages>375-380</pages><issn>0735-6757</issn><eissn>1532-8171</eissn><abstract>Abstract Objective The objective of this study is to determine whether hypothermia will lessen decreases in heart rate variability and improve outcome in a rat model of sepsis. Methods Thirty-six male Sprague-Dawley rats were randomized into 3 groups: control, low sepsis, and high sepsis groups. These groups were each subdivided into a normothermia (37°C) (n = 6) and a hypothermia group (34°C) (n = 6). Cyclophosphamide (100 mg/kg) was administered 5 days before Staphylococcus aureus injection to produce conditions in which sepsis could be induced reliably. Hypothermic rats received temperature reduction for 1 hour post injection. Electrocardiogram was recorded before, after, and 1 day after staphylococcal injection, and the low frequency, high frequency (HF), and LF/HF ratio measurements of heart rate variability and the frequencies of arrhythmia were recorded. The effects of time, sepsis severity, and hypothermia on these variables were analyzed using a multivariate generalized estimation equation mode. Results Four deaths occurred in the normothermic group, and none, in the hypothermic group. Sepsis of both low and high severity increased low frequency and HF 1 day after sepsis induction. Hypothermia significantly decreased HF in low, but not high sepsis severity. Conclusions Hypothermia decreased mortality in septic rats. The influence of hypothermia on HF depended on the severity of the sepsis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23158600</pmid><doi>10.1016/j.ajem.2012.08.028</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Autonomic Nervous System - physiology Bacteria Bacterial infections Blood Disease Models, Animal Electrocardiography Emergency Emergency medical care Feasibility studies Heart rate Heart Rate - physiology Hypothermia Hypothermia, Induced Immunization Infections Injection Injections Logistic Models Male Mortality Multivariate Analysis Random Allocation Rats Rats, Sprague-Dawley Rodents Sepsis Sepsis - mortality Sepsis - physiopathology Sepsis - therapy Severity of Illness Index Staphylococcal Infections - mortality Staphylococcal Infections - physiopathology Staphylococcal Infections - therapy |
| title | The role of autonomic nervous system function in hypothermia-mediated sepsis protection |
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