Assessing the burden of human cysticercosis in Vietnam
Objectives To describe the occurrence of cysticercosis in patients living in rural areas of Northern Vietnam presenting clinical signs of neurocysticercosis. Methods Serological antigen detection, reflecting current infection with viable larval stages of Taenia solium, was used to estimate the preva...
Gespeichert in:
Veröffentlicht in: | Tropical medicine & international health 2013-03, Vol.18 (3), p.352-356 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 356 |
---|---|
container_issue | 3 |
container_start_page | 352 |
container_title | Tropical medicine & international health |
container_volume | 18 |
creator | Trung, Dung Do Praet, Nicolas Cam, Thach Dang Thi Lam, Binh Vu Thi Manh, Hung Nguyen Gabriël, Sarah Dorny, Pierre |
description | Objectives
To describe the occurrence of cysticercosis in patients living in rural areas of Northern Vietnam presenting clinical signs of neurocysticercosis.
Methods
Serological antigen detection, reflecting current infection with viable larval stages of Taenia solium, was used to estimate the prevalence of active cysticercosis in this patient population.
Results
The seroprevalence in epileptic patient population was |
doi_str_mv | 10.1111/tmi.12043 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1288311103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2892181851</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3443-22492086974b0620a941915f16fafe3d9f7a43066d4d0013b0697c5fc4ad69e3</originalsourceid><addsrcrecordid>eNpd0V1LwzAUBuAgipvTC_-AFETwpluSk6bN5Rh-wcSb4W3I0sRltOlsWmT_3uxDBXOTA3k4OZwXoWuCxySeSVe7MaGYwQkaEuBZCiTjp_sap5TmfIAuQlhjjBnL-DkaUKC5yAkfIj4NwYTg_EfSrUyy7NvS-KSxyaqvlU_0NnROm1Y3wYXE-eTdmc6r-hKdWVUFc3W8R2jx-LCYPafzt6eX2XSeboAxiH8zQXHBRc6WmFOsBCOCZJZwq6yBUthcMcCcl6zEmEBEIteZ1UyVXBgYoftD203bfPYmdLJ2QZuqUt40fZCEFgXEDWCI9PYfXTd96-NwO5UXHAqBo7o5qn5Zm1JuWlerdit_FhLB3RGooFVlW-W1C3-OxyYgdm5ycF-uMtvfd4LlLhEZE5H7ROTi9WVfwDeeSnnn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1287863890</pqid></control><display><type>article</type><title>Assessing the burden of human cysticercosis in Vietnam</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Free Archive</source><source>IngentaConnect Open Access</source><source>EZB Electronic Journals Library</source><creator>Trung, Dung Do ; Praet, Nicolas ; Cam, Thach Dang Thi ; Lam, Binh Vu Thi ; Manh, Hung Nguyen ; Gabriël, Sarah ; Dorny, Pierre</creator><creatorcontrib>Trung, Dung Do ; Praet, Nicolas ; Cam, Thach Dang Thi ; Lam, Binh Vu Thi ; Manh, Hung Nguyen ; Gabriël, Sarah ; Dorny, Pierre</creatorcontrib><description>Objectives
To describe the occurrence of cysticercosis in patients living in rural areas of Northern Vietnam presenting clinical signs of neurocysticercosis.
Methods
Serological antigen detection, reflecting current infection with viable larval stages of Taenia solium, was used to estimate the prevalence of active cysticercosis in this patient population.
Results
The seroprevalence in epileptic patient population was <10%. However, antigen detection cannot detect dead cysticerci, which may also cause clinical signs. Therefore, the seroprevalence figures shown here may underestimate the role of neurocysticercosis as a causal agent of epilepsy and headaches in this population.
Conclusions
Human and porcine cysticercosis remain public and veterinary public health problems in Northern Vietnam and probably in other parts of the country.
ObjectifsDécrire l'apparition de la cysticercose chez les patients vivant en milieu rural dans le nord du Vietnam qui présentent des signes cliniques de neurocysticercose.
MéthodesLa détection sérologique de l'antigène, reflétant une infection en cours avec des stades larvaires viables de Taenia solium, a été utilisée pour estimer la prévalence de cysticercose active dans ces populations.
RésultatsLa séroprévalence dans les populations de patients épileptiques était <10%. Cependant, la détection d'antigènes ne peut pas détecter des cysticerques morts, qui peuvent également provoquer des signes cliniques. Par conséquent, les taux de séroprévalence présentés ici pourraient sous‐estimer le rôle de la neurocysticercose comme agent causal de l’épilepsie et des maux de tête dans cette population.
ConclusionsLa cysticercose porcine et humaine restent des problèmes de santé publique et vétérinaire dans le nord du Vietnam et probablement dans d'autres parties du pays.
ObjetivosDescribir la presencia de cisticercosis en pacientes viviendo en zonas rurales del Norte de Vietnam que presentan signos clínicos de neurocisticercosis.
MétodosPara calcular la prevalencia de cisticercosis activa en estas poblaciones se utilizó la detección del antígeno neurológico, como reflejo de la presencia de infección con estadios larvales viables de Taenia solium.
ResultadosLa seroprevalencia en poblaciones de pacientes epilépticos era <10%. Sin embargo la detección del antígeno no se da en individuos con presencia de cisticercos muertos, que por otro lado si pueden provocar signos clínicos. Por lo tanto, los datos de seroprevalencia que aquí se presentan podrían estar subestimando el papel de la neurocisticercosis como agente causal de la epilepsia y de dolores de cabeza en esta población.
ConclusionesLa cisticercosis – humana y porcina – continúa siendo un problema de salud pública y veterinaria en el norte de Vietnam y probablemente en otras partes del país.</description><identifier>ISSN: 1360-2276</identifier><identifier>EISSN: 1365-3156</identifier><identifier>DOI: 10.1111/tmi.12043</identifier><identifier>PMID: 23279716</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; burden ; Child ; Chronic Disease ; clinical signs ; Cysticercosis ; Cysticercosis - epidemiology ; Cysticercosis - veterinary ; Disease Reservoirs ; Diseases caused by cestodes ; Epidermal Cyst - epidemiology ; Epidermal Cyst - parasitology ; Epilepsy ; Epilepsy - epidemiology ; Epilepsy - parasitology ; General aspects ; Headache - epidemiology ; Headache - parasitology ; Headaches ; Helminthic diseases ; Hogs ; Humans ; Infectious diseases ; Medical sciences ; Middle Aged ; neurocysticercosis ; Neurocysticercosis - epidemiology ; Parasitic diseases ; Rural Population ; Seroepidemiologic Studies ; Skin Diseases, Parasitic - epidemiology ; Taenia solium ; Vietnam ; Vietnam - epidemiology</subject><ispartof>Tropical medicine & international health, 2013-03, Vol.18 (3), p.352-356</ispartof><rights>2012 Blackwell Publishing Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2012 Blackwell Publishing Ltd.</rights><rights>2013 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftmi.12043$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftmi.12043$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26903396$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23279716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trung, Dung Do</creatorcontrib><creatorcontrib>Praet, Nicolas</creatorcontrib><creatorcontrib>Cam, Thach Dang Thi</creatorcontrib><creatorcontrib>Lam, Binh Vu Thi</creatorcontrib><creatorcontrib>Manh, Hung Nguyen</creatorcontrib><creatorcontrib>Gabriël, Sarah</creatorcontrib><creatorcontrib>Dorny, Pierre</creatorcontrib><title>Assessing the burden of human cysticercosis in Vietnam</title><title>Tropical medicine & international health</title><addtitle>Trop Med Int Health</addtitle><description>Objectives
To describe the occurrence of cysticercosis in patients living in rural areas of Northern Vietnam presenting clinical signs of neurocysticercosis.
Methods
Serological antigen detection, reflecting current infection with viable larval stages of Taenia solium, was used to estimate the prevalence of active cysticercosis in this patient population.
Results
The seroprevalence in epileptic patient population was <10%. However, antigen detection cannot detect dead cysticerci, which may also cause clinical signs. Therefore, the seroprevalence figures shown here may underestimate the role of neurocysticercosis as a causal agent of epilepsy and headaches in this population.
Conclusions
Human and porcine cysticercosis remain public and veterinary public health problems in Northern Vietnam and probably in other parts of the country.
ObjectifsDécrire l'apparition de la cysticercose chez les patients vivant en milieu rural dans le nord du Vietnam qui présentent des signes cliniques de neurocysticercose.
MéthodesLa détection sérologique de l'antigène, reflétant une infection en cours avec des stades larvaires viables de Taenia solium, a été utilisée pour estimer la prévalence de cysticercose active dans ces populations.
RésultatsLa séroprévalence dans les populations de patients épileptiques était <10%. Cependant, la détection d'antigènes ne peut pas détecter des cysticerques morts, qui peuvent également provoquer des signes cliniques. Par conséquent, les taux de séroprévalence présentés ici pourraient sous‐estimer le rôle de la neurocysticercose comme agent causal de l’épilepsie et des maux de tête dans cette population.
ConclusionsLa cysticercose porcine et humaine restent des problèmes de santé publique et vétérinaire dans le nord du Vietnam et probablement dans d'autres parties du pays.
ObjetivosDescribir la presencia de cisticercosis en pacientes viviendo en zonas rurales del Norte de Vietnam que presentan signos clínicos de neurocisticercosis.
MétodosPara calcular la prevalencia de cisticercosis activa en estas poblaciones se utilizó la detección del antígeno neurológico, como reflejo de la presencia de infección con estadios larvales viables de Taenia solium.
ResultadosLa seroprevalencia en poblaciones de pacientes epilépticos era <10%. Sin embargo la detección del antígeno no se da en individuos con presencia de cisticercos muertos, que por otro lado si pueden provocar signos clínicos. Por lo tanto, los datos de seroprevalencia que aquí se presentan podrían estar subestimando el papel de la neurocisticercosis como agente causal de la epilepsia y de dolores de cabeza en esta población.
ConclusionesLa cisticercosis – humana y porcina – continúa siendo un problema de salud pública y veterinaria en el norte de Vietnam y probablemente en otras partes del país.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>burden</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>clinical signs</subject><subject>Cysticercosis</subject><subject>Cysticercosis - epidemiology</subject><subject>Cysticercosis - veterinary</subject><subject>Disease Reservoirs</subject><subject>Diseases caused by cestodes</subject><subject>Epidermal Cyst - epidemiology</subject><subject>Epidermal Cyst - parasitology</subject><subject>Epilepsy</subject><subject>Epilepsy - epidemiology</subject><subject>Epilepsy - parasitology</subject><subject>General aspects</subject><subject>Headache - epidemiology</subject><subject>Headache - parasitology</subject><subject>Headaches</subject><subject>Helminthic diseases</subject><subject>Hogs</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neurocysticercosis</subject><subject>Neurocysticercosis - epidemiology</subject><subject>Parasitic diseases</subject><subject>Rural Population</subject><subject>Seroepidemiologic Studies</subject><subject>Skin Diseases, Parasitic - epidemiology</subject><subject>Taenia solium</subject><subject>Vietnam</subject><subject>Vietnam - epidemiology</subject><issn>1360-2276</issn><issn>1365-3156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0V1LwzAUBuAgipvTC_-AFETwpluSk6bN5Rh-wcSb4W3I0sRltOlsWmT_3uxDBXOTA3k4OZwXoWuCxySeSVe7MaGYwQkaEuBZCiTjp_sap5TmfIAuQlhjjBnL-DkaUKC5yAkfIj4NwYTg_EfSrUyy7NvS-KSxyaqvlU_0NnROm1Y3wYXE-eTdmc6r-hKdWVUFc3W8R2jx-LCYPafzt6eX2XSeboAxiH8zQXHBRc6WmFOsBCOCZJZwq6yBUthcMcCcl6zEmEBEIteZ1UyVXBgYoftD203bfPYmdLJ2QZuqUt40fZCEFgXEDWCI9PYfXTd96-NwO5UXHAqBo7o5qn5Zm1JuWlerdit_FhLB3RGooFVlW-W1C3-OxyYgdm5ycF-uMtvfd4LlLhEZE5H7ROTi9WVfwDeeSnnn</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Trung, Dung Do</creator><creator>Praet, Nicolas</creator><creator>Cam, Thach Dang Thi</creator><creator>Lam, Binh Vu Thi</creator><creator>Manh, Hung Nguyen</creator><creator>Gabriël, Sarah</creator><creator>Dorny, Pierre</creator><general>Blackwell</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Assessing the burden of human cysticercosis in Vietnam</title><author>Trung, Dung Do ; Praet, Nicolas ; Cam, Thach Dang Thi ; Lam, Binh Vu Thi ; Manh, Hung Nguyen ; Gabriël, Sarah ; Dorny, Pierre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3443-22492086974b0620a941915f16fafe3d9f7a43066d4d0013b0697c5fc4ad69e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>burden</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>clinical signs</topic><topic>Cysticercosis</topic><topic>Cysticercosis - epidemiology</topic><topic>Cysticercosis - veterinary</topic><topic>Disease Reservoirs</topic><topic>Diseases caused by cestodes</topic><topic>Epidermal Cyst - epidemiology</topic><topic>Epidermal Cyst - parasitology</topic><topic>Epilepsy</topic><topic>Epilepsy - epidemiology</topic><topic>Epilepsy - parasitology</topic><topic>General aspects</topic><topic>Headache - epidemiology</topic><topic>Headache - parasitology</topic><topic>Headaches</topic><topic>Helminthic diseases</topic><topic>Hogs</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neurocysticercosis</topic><topic>Neurocysticercosis - epidemiology</topic><topic>Parasitic diseases</topic><topic>Rural Population</topic><topic>Seroepidemiologic Studies</topic><topic>Skin Diseases, Parasitic - epidemiology</topic><topic>Taenia solium</topic><topic>Vietnam</topic><topic>Vietnam - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trung, Dung Do</creatorcontrib><creatorcontrib>Praet, Nicolas</creatorcontrib><creatorcontrib>Cam, Thach Dang Thi</creatorcontrib><creatorcontrib>Lam, Binh Vu Thi</creatorcontrib><creatorcontrib>Manh, Hung Nguyen</creatorcontrib><creatorcontrib>Gabriël, Sarah</creatorcontrib><creatorcontrib>Dorny, Pierre</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Tropical medicine & international health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trung, Dung Do</au><au>Praet, Nicolas</au><au>Cam, Thach Dang Thi</au><au>Lam, Binh Vu Thi</au><au>Manh, Hung Nguyen</au><au>Gabriël, Sarah</au><au>Dorny, Pierre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the burden of human cysticercosis in Vietnam</atitle><jtitle>Tropical medicine & international health</jtitle><addtitle>Trop Med Int Health</addtitle><date>2013-03</date><risdate>2013</risdate><volume>18</volume><issue>3</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>1360-2276</issn><eissn>1365-3156</eissn><abstract>Objectives
To describe the occurrence of cysticercosis in patients living in rural areas of Northern Vietnam presenting clinical signs of neurocysticercosis.
Methods
Serological antigen detection, reflecting current infection with viable larval stages of Taenia solium, was used to estimate the prevalence of active cysticercosis in this patient population.
Results
The seroprevalence in epileptic patient population was <10%. However, antigen detection cannot detect dead cysticerci, which may also cause clinical signs. Therefore, the seroprevalence figures shown here may underestimate the role of neurocysticercosis as a causal agent of epilepsy and headaches in this population.
Conclusions
Human and porcine cysticercosis remain public and veterinary public health problems in Northern Vietnam and probably in other parts of the country.
ObjectifsDécrire l'apparition de la cysticercose chez les patients vivant en milieu rural dans le nord du Vietnam qui présentent des signes cliniques de neurocysticercose.
MéthodesLa détection sérologique de l'antigène, reflétant une infection en cours avec des stades larvaires viables de Taenia solium, a été utilisée pour estimer la prévalence de cysticercose active dans ces populations.
RésultatsLa séroprévalence dans les populations de patients épileptiques était <10%. Cependant, la détection d'antigènes ne peut pas détecter des cysticerques morts, qui peuvent également provoquer des signes cliniques. Par conséquent, les taux de séroprévalence présentés ici pourraient sous‐estimer le rôle de la neurocysticercose comme agent causal de l’épilepsie et des maux de tête dans cette population.
ConclusionsLa cysticercose porcine et humaine restent des problèmes de santé publique et vétérinaire dans le nord du Vietnam et probablement dans d'autres parties du pays.
ObjetivosDescribir la presencia de cisticercosis en pacientes viviendo en zonas rurales del Norte de Vietnam que presentan signos clínicos de neurocisticercosis.
MétodosPara calcular la prevalencia de cisticercosis activa en estas poblaciones se utilizó la detección del antígeno neurológico, como reflejo de la presencia de infección con estadios larvales viables de Taenia solium.
ResultadosLa seroprevalencia en poblaciones de pacientes epilépticos era <10%. Sin embargo la detección del antígeno no se da en individuos con presencia de cisticercos muertos, que por otro lado si pueden provocar signos clínicos. Por lo tanto, los datos de seroprevalencia que aquí se presentan podrían estar subestimando el papel de la neurocisticercosis como agente causal de la epilepsia y de dolores de cabeza en esta población.
ConclusionesLa cisticercosis – humana y porcina – continúa siendo un problema de salud pública y veterinaria en el norte de Vietnam y probablemente en otras partes del país.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>23279716</pmid><doi>10.1111/tmi.12043</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1360-2276 |
ispartof | Tropical medicine & international health, 2013-03, Vol.18 (3), p.352-356 |
issn | 1360-2276 1365-3156 |
language | eng |
recordid | cdi_proquest_miscellaneous_1288311103 |
source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Free Archive; IngentaConnect Open Access; EZB Electronic Journals Library |
subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences burden Child Chronic Disease clinical signs Cysticercosis Cysticercosis - epidemiology Cysticercosis - veterinary Disease Reservoirs Diseases caused by cestodes Epidermal Cyst - epidemiology Epidermal Cyst - parasitology Epilepsy Epilepsy - epidemiology Epilepsy - parasitology General aspects Headache - epidemiology Headache - parasitology Headaches Helminthic diseases Hogs Humans Infectious diseases Medical sciences Middle Aged neurocysticercosis Neurocysticercosis - epidemiology Parasitic diseases Rural Population Seroepidemiologic Studies Skin Diseases, Parasitic - epidemiology Taenia solium Vietnam Vietnam - epidemiology |
title | Assessing the burden of human cysticercosis in Vietnam |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T18%3A43%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20the%20burden%20of%20human%20cysticercosis%20in%20Vietnam&rft.jtitle=Tropical%20medicine%20&%20international%20health&rft.au=Trung,%20Dung%20Do&rft.date=2013-03&rft.volume=18&rft.issue=3&rft.spage=352&rft.epage=356&rft.pages=352-356&rft.issn=1360-2276&rft.eissn=1365-3156&rft_id=info:doi/10.1111/tmi.12043&rft_dat=%3Cproquest_pubme%3E2892181851%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1287863890&rft_id=info:pmid/23279716&rfr_iscdi=true |