Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability

Background The discovery of practical biomarkers is important to realize personalized medicine for patients with malignant neoplasias, including colorectal cancer (CRC). Purpose The aim of this study was to determine reliable prognostic biomarkers by the analysis of patients with resectable colorect...

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Veröffentlicht in:	Journal of hepato-biliary-pancreatic sciences 2013-02, Vol.20 (2), p.223-233
Hauptverfasser:	Umeda, Yuzo, Nagasaka, Takeshi, Mori, Yoshiko, Sadamori, Hiroshi, Sun, Dong-Sheng, Shinoura, Susumu, Yoshida, Ryuich, Satoh, Daisuke, Nobuoka, Daisuke, Utsumi, Masashi, Yoshida, Kazuhiro, Yagi, Takahito, Fujiwara, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Surgery Aged Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism BRAF colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease Progression DNA Mutational Analysis DNA, Neoplasm - genetics Female Follow-Up Studies Gastroenterology Hepatology Humans Japan - epidemiology KRAS liver metastasis Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - secondary Male Medical prognosis Medicine Medicine & Public Health Metastasis Microsatellite Instability Mutation Original Article Polymerase Chain Reaction Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics ras Proteins - metabolism Retrospective Studies Surgical Oncology Survival analysis Survival Rate - trends Tumors
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