Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell–Derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis

OBJECTIVE—Angiogenesis requires tightly coordinated crosstalk between endothelial cells (ECs) and stromal cells, such as fibroblasts and smooth muscle cells. The specific molecular mechanisms moderating this process are still poorly understood. METHODS AND RESULTS—Stromal cell–derived factors are es...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-03, Vol.33 (3), p.513-522
Hauptverfasser:	Newman, Andrew C, Chou, Wayne, Welch-Reardon, Katrina M, Fong, Ashley H, Popson, Stephanie A, Phan, Duc Thien, Sandoval, Daniel R, Nguyen, Dananh P, Gershon, Paul D, Hughes, Christopher C W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chromatography, Liquid Coculture Techniques Enzyme-Linked Immunosorbent Assay Fibroblasts - secretion Fibronectins - genetics Fibronectins - metabolism Fibronectins - secretion Hepatocyte Growth Factor - genetics Hepatocyte Growth Factor - metabolism Hepatocyte Growth Factor - secretion Human Umbilical Vein Endothelial Cells - metabolism Humans Myocytes, Smooth Muscle - secretion Nanotechnology Neovascularization, Physiologic Paracrine Communication Proteomics - methods Real-Time Polymerase Chain Reaction RNA Interference Stromal Cells - secretion Tandem Mass Spectrometry Time Factors Transfection
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