In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine
Abstract Objectives To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with t...
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| Veröffentlicht in: | Journal of dentistry 2013-02, Vol.41 (2), p.155-163 |
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| creator | de Castilho, Aline Rogéria Freire Duque, Cristiane Negrini, Thaís de Cássia Sacono, Nancy Tomoko de Paula, Andréia Bolzan Costa, Carlos Alberto de Souza Spolidório, Denise Madalena Palomari Puppin-Rontani, Regina Maria |
| description | Abstract Objectives To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with the RMGIC applied on remaining dentine after indirect pulp treatment (IPT). Methods For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24 h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24 h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months. Results The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT. Conclusion The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT. |
| doi_str_mv | 10.1016/j.jdent.2012.10.014 |
| format | Article |
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Methods For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24 h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24 h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months. Results The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT. Conclusion The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT.</description><identifier>ISSN: 0300-5712</identifier><identifier>EISSN: 1879-176X</identifier><identifier>DOI: 10.1016/j.jdent.2012.10.014</identifier><identifier>PMID: 23123495</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Actinomyces - drug effects ; Anti-Infective Agents, Local - chemistry ; Anti-Infective Agents, Local - pharmacology ; Anti-Infective Agents, Local - toxicity ; Antibacterial activity ; Antimicrobial agents ; Bacteria ; Bond strength ; Cell culture ; Cell Culture Techniques ; Cell Line ; Cell Shape - drug effects ; Cell Survival - drug effects ; Cement ; Child ; Child, Preschool ; Chlorhexidine - analogs & derivatives ; Chlorhexidine - chemistry ; Chlorhexidine - pharmacology ; Chlorhexidine - toxicity ; Chlorhexidine digluconate ; Coloring Agents ; Compressive Strength ; Dental Caries - microbiology ; Dental Caries - therapy ; Dental Cavity Lining - methods ; Dentin - drug effects ; Dentin - microbiology ; Dentin - pathology ; Dentistry ; Glass ionomer cement ; Glass Ionomer Cements - chemistry ; Glass Ionomer Cements - pharmacology ; Glass Ionomer Cements - toxicity ; Humans ; Indirect pulp therapy ; Lactobacillus acidophilus - drug effects ; Materials Testing ; Mechanical Phenomena ; Mechanical properties ; Microbial Viability - drug effects ; Microbiology ; Microorganisms ; Microscopy, Electron, Scanning ; Odontoblasts - drug effects ; Resin Cements - chemistry ; Resin Cements - pharmacology ; Resin Cements - toxicity ; Streptococcus mutans - drug effects ; Stress, Mechanical ; Tensile Strength ; Tetrazolium Salts ; Thiazoles ; Time Factors</subject><ispartof>Journal of dentistry, 2013-02, Vol.41 (2), p.155-163</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-f7e2bd5ceb4afba46817356949d28e93fbf4d0a8c8c3030fa6d639c588cfec03</citedby><cites>FETCH-LOGICAL-c487t-f7e2bd5ceb4afba46817356949d28e93fbf4d0a8c8c3030fa6d639c588cfec03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300571212002989$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23123495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Castilho, Aline Rogéria Freire</creatorcontrib><creatorcontrib>Duque, Cristiane</creatorcontrib><creatorcontrib>Negrini, Thaís de Cássia</creatorcontrib><creatorcontrib>Sacono, Nancy Tomoko</creatorcontrib><creatorcontrib>de Paula, Andréia Bolzan</creatorcontrib><creatorcontrib>Costa, Carlos Alberto de Souza</creatorcontrib><creatorcontrib>Spolidório, Denise Madalena Palomari</creatorcontrib><creatorcontrib>Puppin-Rontani, Regina Maria</creatorcontrib><title>In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine</title><title>Journal of dentistry</title><addtitle>J Dent</addtitle><description>Abstract Objectives To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with the RMGIC applied on remaining dentine after indirect pulp treatment (IPT). Methods For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24 h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24 h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months. Results The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT. Conclusion The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT.</description><subject>Actinomyces - drug effects</subject><subject>Anti-Infective Agents, Local - chemistry</subject><subject>Anti-Infective Agents, Local - pharmacology</subject><subject>Anti-Infective Agents, Local - toxicity</subject><subject>Antibacterial activity</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bond strength</subject><subject>Cell culture</subject><subject>Cell Culture Techniques</subject><subject>Cell Line</subject><subject>Cell Shape - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Cement</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chlorhexidine - analogs & derivatives</subject><subject>Chlorhexidine - chemistry</subject><subject>Chlorhexidine - pharmacology</subject><subject>Chlorhexidine - toxicity</subject><subject>Chlorhexidine digluconate</subject><subject>Coloring Agents</subject><subject>Compressive Strength</subject><subject>Dental Caries - microbiology</subject><subject>Dental Caries - therapy</subject><subject>Dental Cavity Lining - methods</subject><subject>Dentin - drug effects</subject><subject>Dentin - microbiology</subject><subject>Dentin - pathology</subject><subject>Dentistry</subject><subject>Glass ionomer cement</subject><subject>Glass Ionomer Cements - chemistry</subject><subject>Glass Ionomer Cements - pharmacology</subject><subject>Glass Ionomer Cements - toxicity</subject><subject>Humans</subject><subject>Indirect pulp therapy</subject><subject>Lactobacillus acidophilus - drug effects</subject><subject>Materials Testing</subject><subject>Mechanical Phenomena</subject><subject>Mechanical properties</subject><subject>Microbial Viability - drug effects</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Microscopy, Electron, Scanning</subject><subject>Odontoblasts - drug effects</subject><subject>Resin Cements - chemistry</subject><subject>Resin Cements - pharmacology</subject><subject>Resin Cements - toxicity</subject><subject>Streptococcus mutans - drug effects</subject><subject>Stress, Mechanical</subject><subject>Tensile Strength</subject><subject>Tetrazolium Salts</subject><subject>Thiazoles</subject><subject>Time Factors</subject><issn>0300-5712</issn><issn>1879-176X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAQxyMEokvhEyAhS1y4ZPEjD-cAUlXxqFSJAz1wsxx7vJklsYudjeiH4Dvj7BaQeuE0mtFvnv8pipeMbhllzdv9dm_Bz1tOGc-RLWXVo2LDZNuVrG2-PS42VFBa1i3jZ8WzlPaU0ory7mlxxgXjourqTfHrypMF5xiI9pbg6iwh2wXSjDs9Y_AkODIPQHoMY9ih0eORncAM2h_dHga9YDjEFY2Q0JdTsOgQLNmNOqUylwkTRGJgyiMTE_ys0aPfETOMIQ7wEy16eF48cXpM8OLenhc3Hz_cXH4ur798urq8uC5NJdu5dC3w3tYG-kq7XleNZK2om67qLJfQCde7ylItjTQi38DpxjaiM7WUxoGh4rx4cyp7G8OPQ95UTZgMjKP2EA5JMS6loFI0MqOvH6D7vKfPw61U29WU11WmxIkyMaQUwanbiJOOd4pRtYql9uoollrFWoNZrJz16r72oZ_A_s35o04G3p0AyLdYEKJKBsEbsBjBzMoG_E-D9w_yzYhHyb7DHaR_m6jEFVVf139Z34Vxmv9EduI3x7e-ZA</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>de Castilho, Aline Rogéria Freire</creator><creator>Duque, Cristiane</creator><creator>Negrini, Thaís de Cássia</creator><creator>Sacono, Nancy Tomoko</creator><creator>de Paula, Andréia Bolzan</creator><creator>Costa, Carlos Alberto de Souza</creator><creator>Spolidório, Denise Madalena Palomari</creator><creator>Puppin-Rontani, Regina Maria</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QP</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine</title><author>de Castilho, Aline Rogéria Freire ; Duque, Cristiane ; Negrini, Thaís de Cássia ; Sacono, Nancy Tomoko ; de Paula, Andréia Bolzan ; Costa, Carlos Alberto de Souza ; Spolidório, Denise Madalena Palomari ; Puppin-Rontani, Regina Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-f7e2bd5ceb4afba46817356949d28e93fbf4d0a8c8c3030fa6d639c588cfec03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Actinomyces - drug effects</topic><topic>Anti-Infective Agents, Local - chemistry</topic><topic>Anti-Infective Agents, Local - pharmacology</topic><topic>Anti-Infective Agents, Local - toxicity</topic><topic>Antibacterial activity</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Bond strength</topic><topic>Cell culture</topic><topic>Cell Culture Techniques</topic><topic>Cell Line</topic><topic>Cell Shape - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Cement</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chlorhexidine - analogs & derivatives</topic><topic>Chlorhexidine - chemistry</topic><topic>Chlorhexidine - pharmacology</topic><topic>Chlorhexidine - toxicity</topic><topic>Chlorhexidine digluconate</topic><topic>Coloring Agents</topic><topic>Compressive Strength</topic><topic>Dental Caries - microbiology</topic><topic>Dental Caries - therapy</topic><topic>Dental Cavity Lining - methods</topic><topic>Dentin - drug effects</topic><topic>Dentin - microbiology</topic><topic>Dentin - pathology</topic><topic>Dentistry</topic><topic>Glass ionomer cement</topic><topic>Glass Ionomer Cements - chemistry</topic><topic>Glass Ionomer Cements - pharmacology</topic><topic>Glass Ionomer Cements - toxicity</topic><topic>Humans</topic><topic>Indirect pulp therapy</topic><topic>Lactobacillus acidophilus - drug effects</topic><topic>Materials Testing</topic><topic>Mechanical Phenomena</topic><topic>Mechanical properties</topic><topic>Microbial Viability - drug effects</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Microscopy, Electron, Scanning</topic><topic>Odontoblasts - drug effects</topic><topic>Resin Cements - chemistry</topic><topic>Resin Cements - pharmacology</topic><topic>Resin Cements - toxicity</topic><topic>Streptococcus mutans - drug effects</topic><topic>Stress, Mechanical</topic><topic>Tensile Strength</topic><topic>Tetrazolium Salts</topic><topic>Thiazoles</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Castilho, Aline Rogéria Freire</creatorcontrib><creatorcontrib>Duque, Cristiane</creatorcontrib><creatorcontrib>Negrini, Thaís de Cássia</creatorcontrib><creatorcontrib>Sacono, Nancy Tomoko</creatorcontrib><creatorcontrib>de Paula, Andréia Bolzan</creatorcontrib><creatorcontrib>Costa, Carlos Alberto de Souza</creatorcontrib><creatorcontrib>Spolidório, Denise Madalena Palomari</creatorcontrib><creatorcontrib>Puppin-Rontani, Regina Maria</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Castilho, Aline Rogéria Freire</au><au>Duque, Cristiane</au><au>Negrini, Thaís de Cássia</au><au>Sacono, Nancy Tomoko</au><au>de Paula, Andréia Bolzan</au><au>Costa, Carlos Alberto de Souza</au><au>Spolidório, Denise Madalena Palomari</au><au>Puppin-Rontani, Regina Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine</atitle><jtitle>Journal of dentistry</jtitle><addtitle>J Dent</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>41</volume><issue>2</issue><spage>155</spage><epage>163</epage><pages>155-163</pages><issn>0300-5712</issn><eissn>1879-176X</eissn><abstract>Abstract Objectives To evaluate: (1) the in vitro antibacterial, cytotoxic and mechanical properties of a resin-modified glass ionomer cement (RMGIC) containing different concentrations of chlorhexidine (CHX) and (2) the in vivo microbiologic action of the best concentration of CHX associated with the RMGIC applied on remaining dentine after indirect pulp treatment (IPT). Methods For the in vitro studies, RMGIC was associated with 0.2, 0.5, 1.25 and 2.5% CHX. Microbiologic evaluation consisted of an agar diffusion test on cariogenic bacteria for 24 h. Odontoblast-like cell metabolism and morphology analyses measured the cytotoxic effects of the RMGIC groups after 24 h. The same groups were submitted to compressive and diametral tensile strength. The in vivo treatment consisted of IPT using an RMGIC associated with the best CHX concentration. Clinical and microbiologic evaluations were performed before and after 3 months. Results The use of 1.25% CHX significantly improved the antibacterial effects of the evaluated RMGIC, without causing any detrimental effects to the odontoblast-like cells and on the mechanical properties. This RMGIC and CHX combination completely eliminated mutans streptococci after 3 months of IPT. Conclusion The RMGIC and 1.25% CHX mixture showed great biological and mechanical behaviour and could be a good treatment against caries progression. Clinical significance The association of CHX with a liner RMGIC opens a new perspective for arresting residual caries after IPT.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23123495</pmid><doi>10.1016/j.jdent.2012.10.014</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Actinomyces - drug effects Anti-Infective Agents, Local - chemistry Anti-Infective Agents, Local - pharmacology Anti-Infective Agents, Local - toxicity Antibacterial activity Antimicrobial agents Bacteria Bond strength Cell culture Cell Culture Techniques Cell Line Cell Shape - drug effects Cell Survival - drug effects Cement Child Child, Preschool Chlorhexidine - analogs & derivatives Chlorhexidine - chemistry Chlorhexidine - pharmacology Chlorhexidine - toxicity Chlorhexidine digluconate Coloring Agents Compressive Strength Dental Caries - microbiology Dental Caries - therapy Dental Cavity Lining - methods Dentin - drug effects Dentin - microbiology Dentin - pathology Dentistry Glass ionomer cement Glass Ionomer Cements - chemistry Glass Ionomer Cements - pharmacology Glass Ionomer Cements - toxicity Humans Indirect pulp therapy Lactobacillus acidophilus - drug effects Materials Testing Mechanical Phenomena Mechanical properties Microbial Viability - drug effects Microbiology Microorganisms Microscopy, Electron, Scanning Odontoblasts - drug effects Resin Cements - chemistry Resin Cements - pharmacology Resin Cements - toxicity Streptococcus mutans - drug effects Stress, Mechanical Tensile Strength Tetrazolium Salts Thiazoles Time Factors |
| title | In vitro and in vivo investigation of the biological and mechanical behaviour of resin-modified glass-ionomer cement containing chlorhexidine |
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